Effects of aging on evoked otoacoustic emissions in the common marmoset

衰老对普通狨猴诱发耳声发射的影响

基本信息

批准号：
7758727
负责人：
RAMA RATNAM
金额：
$ 10.51万
依托单位：
UNIVERSITY OF TEXAS SAN ANTONIO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-15 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7758727
关键词：
Accounting Acoustic Stimulation Acoustics Address Amplifiers Anesthesia procedures Animals Attenuated Auditory Back Basilar Membrane Biological Models Breeding Budgets CYP19A1 gene Callithrix Callithrix jacchus jacchus Clinical Cochlea Communication Confidence Intervals Contralateral Critiques Data Diagnostic Disease Ear Electrophysiology (science)Engineering Experimental Designs External auditory canal Frequencies Goals Health Health Status Hearing Hour Human Implant Investigation Life Longevity Longitudinal Studies Measurement Measures Mentors Methods Minor Noise Organ Outer Hair Cells Physiological Processes Physiology Primates Procedures Process Prosthesis Reflex action Reproducibility Research Research Design Sample Size Schedule Specific qualifier value Study models System Techniques Testing Tympanic membrane Tympanometry Work Writing acoustic reflex age effect age group age related austin base ear muscle experience hearing impairment improved meetings member middle ear neuromechanism otoacoustic emission posters response sound

项目摘要

DESCRIPTION (provided by applicant): The broad goal of this project is to determine the effects of aging on the cochlea of a new world primate, the common marmoset (Callithrix jacchus). Specifically, this project will determine the functioning of the cochlea and the auditory efferent system by measuring otoacoustic emissions (OAEs). This non-invasive technique, which measures sounds in the ear canal originating in the micromechanical activity of the basilar membrane, provides useful information on the health and status of the cochlea, particularly the outer hair cells (OHCs). When there is cochlear damage or hearing loss, OAEs are absent or their strength is diminished. The efferent system improves hearing in noise by inhibiting OHCs and thereby attenuates OAE amplitudes. It can be activated by stimulating the contralateral ear. When the efferent system is ineffective OAEs are not readily suppressed by contralateral stimulation. OAEs have important clinical and diagnostic applications in addition to providing information on certain cochlear processes, and thus they are useful for determining age-related changes in cochlear functioning. The marmoset is an attractive model system for this study because it is a relatively short-lived primate, having an average life span of seven to eight years, is easily bred in captivity, and relies on vocal communication for maintaining contact with group members. While the marmoset is emerging as a model for studying central auditory function, there are no studies on the auditory periphery of this species. This project will therefore take the first steps towards determining the status of the marmoset cochlea and provide data on the effects of aging on cochlear functioning. The experimental goals of the project are to measure evoked OAES (i.e. emissions that are elicited in response to acoustic stimulation of the tympanic membrane). Two types of evoked emissions will be measured, namely distortion product (DP) OAEs and click-evoked (CE) OAEs, so-called because the former uses two pure tones to elicit a (nonlinear) cubic distortion product, while the latter uses an impulsive click to elicit broadband responses. The experimental goals of the project will (1) determine the effects of aging on measured OAE responses, and (2) determine the functioning of the auditory efferent system by measuring OAEs in response to stimulation of the contralateral ear. The long-term goal of the research is to comprehensively investigate the marmoset auditory periphery using a variety of non-invasive and electrophysiological procedures, and develop prosthetic implants for treating hearing loss. The project will determine the effects of aging on the functioning of the cochlea (the hearing organ) of a new world primate, the common marmoset (Callithrix jacchus). This study will measure otoacoustic emissions (OAEs), which are sounds reflected back from the cochlea in response to acoustic stimulation of the ear. OAEs provide information on the health of the cochlear amplifier, a physiological process that is important for normal hearing, and thus it can be used to determine the effects of aging on cochlear functioning.

描述（由申请人提供）：该项目的广泛目标是确定衰老对新世界灵长类动物（Common Marmoset（Callithrix Jacchus））的耳蜗的影响。具体而言，该项目将通过测量耳声发射（OAE）来确定耳蜗和听觉辐射系统的功能。这种非侵入性技术测量的是在基底膜的微机械活性的耳道中的声音，它提供了有关耳蜗的健康和状态，尤其是外毛细胞（OHC）的有用信息。当有耳蜗损害或听力损失时，OAES缺失或强度会降低。传出系统通过抑制OHC来改善噪声的听力，从而减轻OAE振幅。可以通过刺激对侧耳朵来激活它。当传出系统无效时，对侧刺激不容易抑制OAE。 OAE除了提供有关某些耳蜗过程的信息外，还具有重要的临床和诊断应用，因此它们对于确定与年龄相关的人工耳蜗功能的变化很有用。 Marmoset是这项研究的有吸引力的模型系统，因为它是一种相对短暂的灵长类动物，平均寿命为七到八年，很容易被囚禁，并且依靠声带沟通来保持与小组成员的接触。虽然Marmoset是研究中央听觉功能的模型，但没有关于该物种的听觉外围的研究。因此，该项目将采取第一步，以确定Marmoset Cochlea的状态，并提供有关老化对耳蜗功能的影响的数据。该项目的实验目标是测量诱发的OAE（即，由于鼓膜刺激鼓膜而引起的排放）。将测量两种类型的诱发排放，即失真产物（DP）OAE和点击诱发的OAE（CE）OAE，因为前者使用两个纯音调引起（非线性）立方体失真产品，而后者则使用A（冲动单击以引起宽带响应。项目的实验目标（1）确定衰老对测得的OAE响应的影响，（2）通过响应刺激对侧耳朵来测量OAE来确定听觉传出系统的功能。该研究的长期目标是使用各种非侵入性和电生理程序全面研究Marmoset听觉外围，并开发用于治疗听力损失的假肢植入物。该项目将确定衰老对新世界灵长类动物（听力器官）（听力器官）功能的影响，即普通果果（Callithrix jacchus）。这项研究将测量耳声发射（OAE），这些发声是从耳蜗反射的，响应于耳朵的声刺激。 OAE提供有关人工耳蜗的健康的信息，这是一种对正常听力很重要的生理过程，因此可以用来确定衰老对耳蜗功能的影响。