Optimized Conditioned Processing for Cochlear Implants

人工耳蜗的优化调节处理

• 批准号: 7749927
• 负责人: Jay T. Rubinstein
• 金额: $ 37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-09 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7749927
• 关键词: Acoustic Nerve; Acoustics; Animal Model; Animals; Auditory; Auditory system; Basilar Membrane; Bilateral; Brain Stem; Categories; Clinical; Cochlear Implants; Code; Complement; Complex; Computer Simulation; Computers; Cues; Data; Electrodes; Equilibrium; Frequencies; Goals; Growth; Hearing; Human; Implant; Loudness; Maps; Methods; Nerve; Nerve Fibers; Neurons; Noise; Patients; Pattern; Perception; Performance; Physiologic pulse; Physiological; Pilot Projects; Pitch Perception; Population; Principal Investigator; Procedures; Process; Psychophysiology; Pulse Rates; Research Personnel; Resolution; Shapes; Signal Transduction; Speech; Speech Discrimination; Speech Perception; Stimulus; Testing; Time; Time Perception; Training; Work; base; computerized data processing; conditioning; ganglion cell; implantable device; improved; programs; simulation; sound; spiral ganglion; Acoustic Nerve; Acoustics; Animal Model; Animals; Auditory; Auditory system; Basilar Membrane; Bilateral; Brain Stem; Categories; Clinical; Cochlear Implants; Code; Complement; Complex; Computer Simulation; Computers; Cues; Data; Electrodes; Equilibrium; Frequencies; Goals; Growth; Hearing; Human; Implant; Loudness; Maps; Methods; Nerve; Nerve Fibers; Neurons; Noise; Patients; Pattern; Perception; Performance; Physiologic pulse; Physiological; Pilot Projects; Pitch Perception; Population; Principal Investigator; Procedures; Process; Psychophysiology; Pulse Rates; Research Personnel; Resolution; Shapes; Signal Transduction; Speech; Speech Discrimination; Speech Perception; Stimulus; Testing; Time; Time Perception; Training; Work; base; computerized data processing; conditioning; ganglion cell; implantable device; improved; programs; simulation; sound; spiral ganglion

High levels of speech perception in quiet are currently available to a significant percentage of modern cdchlear implant recipients. In a noisy background, however, particularly if that noise is competing speech, speech perception is dramatically impaired. One possible method for improving speech perception in noise is to improve the temporal representation of speech in discharge patterns of electrically stimulated auditory nerve fibers. This method would also be expected to improve the performance of bilateral implant recipients on tasks requiring brainstem analysis of interaural timing. Detailed biophysical models and animal studies have demonstrated that improved temporal representation can be accomplished through the use of "conditioning stimuli" - trains of unmodulated high-rate pulses that desynchronize activity of auditory neurons to competing signals. Use of this procedure has led to dramatically increased speech perception in quiet and/or noise in some subjects, but not in others. The goal of the proposed work is to optimize the presentation of both the speech signal and the conditioner so as to maximize speech perception in quiet and noise for unilateral implant recipients, as well as improve perception of temporally-based lateralization and binaural unmasking in bilateral implantees. Because temporal pitch mechanisms demand accurate place information if they are to be useful, and pitch is thought critical for speech discrimination in competing speech, filter-to-electrode mappings will be manipulated in conditioned speech processors to maximize performance on a test of spondees in steady-state noise, "babble noise", temporally modulated noise, as well as on HINT sentences in speech-shaped noise. The results will allow optimization of conditioned processors for unilateral and bilateral cochlear implant recipients. In those bilateral implant recipients who have interaural timing perception for electrical stimuli in the physiologic range, this work has the potential to provide significant additional binaural benefits from a clinical speech processor beyond those currently available via interaural amplitude differences. In unilateral implantees, this work has already demonstrated substantial benefit in a limited number of subjects; it is our goal to deliver these benefits to the broader population of implant recipients.

目前，很大一部分现代的语音感知高度可用 CDCHLEAL植入接收者。但是，在嘈杂的背景下，尤其是在噪音是竞争演讲的情况下， 语音感知受到巨大损害。改善噪声语音感知的一种可能方法 是在电刺激的听觉的放电模式下改善语音的时间表示 神经纤维。该方法也有望改善双侧植入物的性能 需要接受脑干间时机分析的任务的接收者。详细的生物物理模型和 动物研究表明，可以通过 使用“调节刺激” - 未经调制的高速脉冲的火车使听觉活性不同步 竞争信号的神经元。此过程的使用导致语音感知大大增加 在某些主题中安静和/或噪音，但在另一些主题中没有。拟议工作的目的是优化 语音信号和护发素的呈现，以最大程度地提高语音感知 和单侧植入物的噪声，并改善对时间侧向化的感知 和双侧植入器中的双耳透明。因为时间倾斜机制需要准确 如果将信息有用，请放置信息，并且认为对于竞争中的语音歧视至关重要 语音，过滤到电极映射将在条件语音处理器中操纵以最大化 在稳态噪声，“ babble噪声”，时间调制的噪声中的脊髓测试的性能 以及言语噪音的提示。结果将允许优化条件 单侧和双侧人工耳管植入受体的处理器。在那些双边植入的接受者中 具有对生理范围内电刺激的时机感觉感知，这项工作有可能 除了目前 可通过耳间幅度差异获得。在单方面植入器中，这项工作已经证明 在有限数量的受试者中获得可观的好处；我们的目标是为更广泛的 植入接收者的人口。