Bioengineering Research Partnership in Total Joint Replacements

全关节置换生物工程研究合作伙伴关系

• 批准号: 7879329
• 负责人: Yogesh K. Vohra
• 金额: $ 19.58万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879329
• 关键词: Academy; Adhesions; Adult; Affect; Air; Alloys; American; Apoptosis; Applications Grants; Biocompatible Materials; Biological; Biological Assay; Biomedical Engineering; Blood; Body Fluids; Chemicals; Clinical; Clinical Trials; Cobalt; Couples; Deposition; Development; Devices; Diamond; Dinoprostone; Endotoxins; Exhibits; Experimental Designs; Failure; Finite Element Analysis; Friction; Future; Goals; Hardness; Hip region structure; Hour; Human; Implant; In Vitro; Industry; Interleukin-1; Interleukin-6; Investigation; Joint Dislocation; Joints; Knee; Lead; Life; Liquid substance; Measures; Mechanics; Mesenchymal Stem Cells; Metals; Methods; Modeling; Motion; NIH Program Announcements; Nanotechnology; New Zealand; Operative Surgical Procedures; Orthopedics; Oryctolagus cuniculus; Osseointegration; Osteolysis; Outcome Study; Pain; Particle Size; Polyethylenes; Property; Protocols documentation; Rattus; Recurrence; Replacement Arthroplasty; Research; Resistance; Route; Services; Simulate; Sterility; Structure; Surface; Surgeon; Testing; Thick; Time; Tissues; Titanium; Universities; Weight-Bearing state; biomaterial compatibility; bone; clinically relevant; cytokine; cytotoxicity; design; hip replacement arthroplasty; implant coating; implantable device; improved; in vivo; knee replacement arthroplasty; macrophage; nano; nanostructured; particle; public health relevance; research study; response; restoration; sample fixation; statistics; substantia spongiosa; success; tool; vapor

DESCRIPTION (provided by applicant): In this University-Industry Partnership, we are focused on development and testing of diamond-on-diamond and diamond-on-polyethylene surfaces for minimizing wear between articulation components in orthopaedic devices. Complications arising from wear include component loosening, deleterious biological responses, osteolysis, mechanical instability, decreased joint mobility, increased pain, and ultimately implant failure. In this project, UAB and Smith & Nephew, Inc. team up to develop and test unique nanostructured multilayer diamond coatings on metal (CoCrMo or Ti-6Al-4V) orthopaedic devices with the goal of reducing friction and wear in articulation components. We propose a five-year study to focus on the following specific aims: Specific Aim 1: Develop nanotechnology for reducing friction and wear on the articulating, load-bearing components of hip and knee metallic implants by chemical vapor deposition (CVD) of a diamond coating having a multilayer structure with alternating nano- and micro-structural layered components. Specific Aim 2: Demonstrate that the multilayer diamond coatings (intended for diamond-on- diamond or diamond-on-polyethylene articulation) exhibit improved wear resistance when compared to single- layer diamond-on-diamond articulation or to the metal-on-polyethylene or metal-on-metal couples currently used in commercial orthopaedic devices. Specific Aim 3: Perform wear simulator studies involving diamond coated hip and knee articulation components using the industry-standard multi-axis hip and knee simulators located at Smith & Nephew, Inc. Specific Aim 4: Evaluate cellular response to diamond wear debris particles, as compared to polyethylene and cobalt chrome debris particles. Specific Aim 5: Perform in vivo investigations to characterize the initial short term organic and cellular responses of control and diamond biomaterials to overall biocompatibility profiles. Wear debris collected from the tribological studies will be implanted (injected) into the synovial-like air pouch model in the adult rat for short term (hours to days) in order to assess clinical, cellular, histological and cytokine biocompatibility profiles. Implants of discs into trabecular bone regions of rabbits will assess initial tissue fluid and blood interactions with control and coated implant surfaces for time points ranging from hours to months. The overall clinical impact of this proposed BRP would be in improving the service life time of total joint replacements to more than thirty years and hence dramatically reducing the need for recurrent multiple surgical procedures. PUBLIC HEALTH RELEVANCE: We propose the use of nanotechnology approaches for controlling interfaces between the hip and knee implants and the surrounding tissues. The primary focus of this grant application is to improve the fixation, durability and osseointegration for long-term success of Total Joint Replacements and lower the need for recurrent multiple surgical procedures. Also, development of new nanotechnology tools and methods will lead to a new class of functionalized nanostructured surfaces for titanium and cobalt chrome alloys for use in biomedical implant industry. One benefit of the diamond-diamond components will be reductions in overall device size that will ultimately allow for a clinically less-invasive route to joint restoration and longer implant lifetime in vivo.

描述（由申请人提供）：在这个大学-工业合作伙伴关系中，我们专注于金刚石对金刚石和金刚石对聚乙烯表面的开发和测试，以最大限度地减少骨科器械中关节部件之间的磨损。磨损引起的并发症包括组件松动、有害的生物反应、骨质溶解、机械不稳定、关节活动度下降、疼痛加剧以及最终的植入失败。在该项目中，UAB 和 Smith & Nephew, Inc. 合作开发和测试金属（CoCrMo 或 Ti-6Al-4V）骨科器械上独特的纳米结构多层金刚石涂层，目的是减少关节部件的摩擦和磨损。我们提出一项为期五年的研究，重点关注以下具体目标： 具体目标 1：开发纳米技术，通过金刚石化学气相沉积 (CVD) 减少髋关节和膝关节金属植入物的关节、承重部件上的摩擦和磨损具有交替纳米结构和微米结构层状成分的多层结构的涂层。具体目标 2：证明多层金刚石涂层（用于金刚石对金刚石或金刚石对聚乙烯铰接件）与单层金刚石对金刚石铰接件或金属对聚乙烯铰接件相比，具有更高的耐磨性或目前用于商业矫形器械的金属对金属对。具体目标 3：使用 Smith & Nephew, Inc. 的行业标准多轴髋关节和膝关节模拟器进行涉及金刚石涂层髋关节和膝关节组件的磨损模拟器研究。具体目标 4：评估细胞对金刚石磨损碎片颗粒的反应，如与聚乙烯和钴铬碎片颗粒相比。具体目标 5：进行体内研究，以表征对照和金刚石生物材料对整体生物相容性特征的初始短期有机和细胞反应。从摩擦学研究中收集的磨损碎片将被短期（数小时至数天）植入（注射）到成年大鼠的滑膜样气囊模型中，以评估临床、细胞、组织学和细胞因子生物相容性特征。将椎间盘植入兔子的骨小梁区域，将评估初始组织液和血液与对照和涂层植入物表面的相互作用，时间点从几小时到几个月不等。该提议的 BRP 的总体临床影响是将全关节置换术的使用寿命提高到三十年以上，从而大大减少重复多次外科手术的需要。公共健康相关性：我们建议使用纳米技术方法来控制髋关节和膝关节植入物与周围组织之间的界面。该拨款申请的主要重点是改善全关节置换术的长期成功的固定、耐用性和骨整合，并降低重复多次外科手术的需要。此外，新纳米技术工具和方法的开发将带来用于生物医学植入物行业的新型钛和钴铬合金功能化纳米结构表面。金刚石-金刚石组件的好处之一是减小装置的整体尺寸，最终将实现临床上侵入性较小的关节修复途径，并延长体内植入物的使用寿命。