Botanicals and Metabolic Syndrome

植物药和代谢综合症

• 批准号: 7626062
• 负责人: William T. Cefalu
• 金额: $ 145.65万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7626062
• 关键词: Botanicals; Metabolic; Syndrome

This application is for a Dietary Supplement Research Center focusing on Botanicals, The application is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) system and the Center of Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. Metabolic syndrome represents one of the most important public health problems facing our society today as the prevalence is reaching epidemic proportions worldwide. Our Botanical Research Center will consist of three (3) specific research projects, an animal research core, a botanical core and an administrative core. Each of the research projects evaluates a specific botanical and assesses the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. The research aims of the projects span both the basic and clinical sciences. Investigators in Project 1 will follow-up on data suggesting that an extract of Russian Tarragon (PMI 5011) enhances insulin action and will conduct detailed molecular and cellular determinants of insulin, sensitivity (i.e. cellular signaling) in both animal and in early human studies. In Project 2, investigators have demonstrated that Shilianhua (SLH) has an effect to attenuate diet-induced obesity and propose to further characterize the metabolic activity, mechanism of action and bioactive compounds of SLH. Investigators in Project 3 hypothesize that anthocyanins, through modulation of the activities of specific nuclear hormone receptors, increase the peripheral oxidation of fatty acids and thereby decrease ectopic fat accumulation in muscle and liver and improve insulin sensitivity. Thus, the key scientific goal of this BRC application is the pursuit of an understanding of the cellular mechanisms by which botanicals may prevent or reverse insulin resistance, obesity and other components of the metabolic syndrome. Attainment of our goal will not only allow for specific investigation into the underlying mechanisms of this condition, but will provide the necessary data for future clinical trials designed to evaluate the effect of botanicals to intervene in the process.

该应用程序适用于专注于植物药的膳食补充剂研究中心，该应用程序是路易斯安那州立大学 (LSU) 系统彭宁顿生物医学研究中心和罗格斯大学农业与环境中心之间的合作成果。该中心的主题是“植物药和代谢综合症”。 “代谢综合征”定义了一种人类病症，其主要特征包括肥胖、胰岛素抵抗、2型糖尿病的发展和加速心血管疾病。代谢综合征是当今社会面临的最重要的公共卫生问题之一，其患病率在全球范围内已达到流行病的程度。我们的植物研究中心将包括三 (3) 个具体研究项目、一个动物研究核心、一个 植物核心和行政核心。每个研究项目都会评估一种特定的植物，并评估其对细胞机制的影响，这些细胞机制有助于代谢综合征的病理生理学和发展。这些项目的研究目标涵盖基础科学和临床科学。项目 1 的研究人员将跟踪表明俄罗斯龙蒿提取物 (PMI 5011) 增强胰岛素作用的数据，并将在动物和早期人类研究中进行详细的胰岛素分子和细胞决定因素、敏感性（即细胞信号传导）。在项目2中，研究人员证明石连花（SLH）具有减轻饮食引起的肥胖的作用，并建议进一步表征SLH的代谢活性、作用机制和生物活性化合物。项目 3 的研究人员假设花青素通过调节 特定的核激素受体，增加脂肪酸的外周氧化，从而减少肌肉和肝脏中的异位脂肪积累，并提高胰岛素敏感性。因此，该 BRC 应用的关键科学目标是寻求对植物药预防或逆转胰岛素抵抗、肥胖和代谢综合征其他组成部分的细胞机制的理解。实现我们的目标不仅可以 对这种情况的潜在机制进行具体研究，但将为未来旨在评估植物干预该过程的效果的临床试验提供必要的数据。