Botanicals and Metabolic Syndrome

植物药和代谢综合症

• 批准号: 8543509
• 负责人: William T. Cefalu
• 金额: $ 158.9万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8543509
• 关键词: Agriculture; Animals; Artemisia; Asclepias; Attenuated; Biology; Biomedical Research; Biotechnology; Botanicals; Cardiovascular Diseases; Desire for food; Development; Energy Metabolism; Environment; Epidemic; Evaluation; Functional disorder; Goals; Health; Human; Hypericum perforatum; Insulin; Insulin Receptor; Insulin Resistance; Louisiana; Metabolic syndrome; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathologic Processes; Phase; Physiological; Prevalence; Proteomics; Public Health; Receptor Signaling; Research; Research Personnel; Research Project Grants; Resistance development; Societies; System; Technology; Translating; Universities; Weight; adipocyte differentiation; adipokines; dietary supplements; energy balance; improved; insulin sensitivity; metabolomics; public health relevance

DESCRIPTION (provided by applicant): This application is for a renewal of our Dietary Supplement Research Center focusing on Botanicals. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Biotechnology Center for Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. As the prevalence of metabolic syndrome is reaching epidemic proportions worldwide, metabolic syndrome has been, and will continue to be, one of the most important public health problems facing society. Our Botanical Research Center will consist of three (3) research projects, an Integrative Biology Core, a Botanical core and an Administrative core. Each of the research projects will evaluate specific botanicals and assess the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. Project 1 investigators will conduct studies to evaluate mechanisms of action by which selected extracts of Artemisia sp. modulate insulin receptor signaling and insulin sensitivity in both animal and in early phase human studies. Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action. Project 3 investigators will evaluate how Asclepias incarnata modulates central mechanisms controlling appetite and energy expenditure as a means to improve overall energy balance and weight. We propose to use cutting-edge technologies that include metabolomic profiling, proteomic assessments, and bioaccessibility determinations. Thus, the scientific goal of our Center is to provide a comprehensive evaluation of specific, compelling hypotheses about the molecular, cellular and physiological mechanisms by which botanicals can modulate the development of the underlying pathophysiologic mechanisms of, and attenuate the development to, metabolic syndrome.

描述（由申请人提供）：本申请旨在更新我们的膳食补充剂研究中心，重点关注植物药。我们的植物研究中心是路易斯安那州立大学 (LSU) 系统彭宁顿生物医学研究中心和罗格斯大学农业与环境生物技术中心的合作成果。该中心的主题是“植物药和代谢综合症”。 “代谢综合征”定义了一种人类病症，其主要特征包括肥胖、胰岛素抵抗、2型糖尿病的发展和加速心血管疾病。随着代谢综合征的患病率在世界范围内达到流行病的程度，代谢综合征已经并将继续是社会面临的最重要的公共卫生问题之一。我们的植物研究中心将由三 (3) 个研究项目组成：一个综合生物学核心、一个植物核心和一个行政核心。每个研究项目都将评估特定的植物药，并评估对细胞机制的影响，这些细胞机制有助于代谢综合征的病理生理学和发展。项目 1 的研究人员将进行研究，以评估选定的蒿提取物的作用机制。在动物和早期人类研究中调节胰岛素受体信号传导和胰岛素敏感性。项目 2 的研究人员将重点研究选择蒿属植物的机制。提取物和贯叶连翘（圣约翰草）影响脂肪细胞发育、脂肪因子和胰岛素作用。项目 3 的研究人员将评估马利筋如何调节控制食欲和能量消耗的中央机制，以此作为改善整体能量平衡和体重的手段。我们建议使用尖端技术，包括代谢组学分析、蛋白质组学评估和生物可及性测定。因此，我们中心的科学目标是对有关分子、细胞和生理机制的具体、令人信服的假设进行全面评估，通过这些假设植物可以调节代谢综合征的潜在病理生理机制的发展，并减轻代谢综合征的发展。