Center for the Study of Reproductive Biology and Women's Health

生殖生物学与妇女健康研究中心

• 批准号: 7628842
• 负责人: JEFFREY W. POLLARD
• 金额: $ 134.82万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-03 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628842
• 关键词: Center; Study; Reproductive; Biology; Women

DESCRIPTION (provided by applicant): The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported "Center for the Study of Reproductive Biology and Women's Health" founded in 2003 at the Albert Einstein College of Medicine with Dr. Pollard as Director. This Center drew together disparate strands of research in the female reproduction at the institution to form a distinct group of interactive individuals who have a translational focus. Investigators with this Center have worked for the last four years to develop this submission and in doing so have met regularly to undertake collaborative projects and used institutional funds to support clinical fellowship training relevant to the study of female reproduction. In doing so the PI's of the proposed projects have all published with one another and they have identified several fellows to be brought onto faculty to perform clinical/basic science research. The SCCPIR has four Projects (Projects 1 and 2 being clinical) and an administrative core as follows: Project 1. Dr. Jeffrey Pollard (PI) - Estrogen and Progesterone Regulation of Human Endometrial Cell Proliferation. Project 2. Dr. Nanette Santoro (PI) - Reproductive hormonal alterations in obesity. Project 3. Dr. Anne Etgen (PI) - IGF-I and Neuroendocrine Regulation of Female Reproductive Function. Project 4. Dr. Streamson Chua (PI) - Antagonistic actions of melanocortins and leptin on reproductive competence. A senior investigator leads all of these projects. There is integration amongst the projects through studies on the roles of obesity and nutrition in reproductive biology as well as the relationship between the insulin-like growth factor-1 axis and estrogen action. The PI, Dr. Jeffrey W. Pollard, is an internationally known researcher in reproductive biology having been, amongst other things, Chair of the Reproductive Tract Gordon Conference. He holds several senior administrative appointments in the College of Medicine and is well able to administer the proposed SCCPIR internally and to enable effective interactions with other SCCPIRs.

描述（由申请人提供）：拟议的生殖和不孕不育研究专业合作中心计划 (SCCPIR) 的重点是女性生殖生物学，由 Jeffrey W. Pollard 博士担任首席研究员。它的前身是 2003 年在阿尔伯特·爱因斯坦医学院成立的机构支持的“生殖生物学和妇女健康研究中心”，波拉德博士担任主任。该中心汇集了该机构女性生殖领域的不同研究领域，形成了一个由具有转化焦点的独特互动个体组成的群体。该中心的研究人员在过去四年中一直致力于编写这份报告，并在此过程中定期会面开展合作项目，并利用机构资金支持与女性生殖研究相关的临床奖学金培训。在此过程中，拟议项目的 PI 均已相互发表，并且他们已经确定了几名研究员将被带入教职人员进行临床/基础科学研究。 SCCPIR 有四个项目（项目 1 和 2 为临床项目）和行政核心如下： 项目 1. Jeffrey Pollard 博士 (PI) - 人类子宫内膜细胞增殖的雌激素和孕激素调节。项目 2. Nanette Santoro 博士（PI）——肥胖中的生殖激素变化。项目 3. Anne Etgen 博士 (PI) - IGF-I 和女性生殖功能的神经内分泌调节。项目 4. Streamson Chua 博士 (PI) - 黑皮质素和瘦素对生殖能力的拮抗作用。一名高级研究员领导所有这些项目。通过研究肥胖和营养在生殖生物学中的作用以及胰岛素样生长因子 1 轴和雌激素作用之间的关系，这些项目之间进行了整合。首席研究员 Jeffrey W. Pollard 博士是国际知名的生殖生物学研究员，曾担任生殖道戈登会议主席。他在医学院担任多项高级行政职务，能够很好地在内部管理拟议的 SCCPIR，并能够与其他 SCCPIR 进行有效互动。