The Impact of Indoor Particulate Matter Exposure on Non-Allergic Asthma

室内颗粒物暴露对非过敏性哮喘的影响

• 批准号: 7885269
• 负责人: MEREDITH C MCCORMACK
• 金额: $ 19.18万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7885269
• 关键词: Acute; Address; Affect; Air Pollutants; Air Pollution; Airborne Particulate Matter; Allergens; Allergic; American; Area; Asthma; Benzene; Biological Markers; Blood; Blood gas; Breathing; Child; Child health care; Chronic; Clinical; Clinical Investigator; Clinical Research; Data; Data Analyses; Deposition; Disadvantaged; Disease; Employee Strikes; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Monitoring; Epidemiologic Studies; Epidemiology; Equipment; Ethics; Exhalation; Experimental Designs; Exposure to; Extrinsic asthma; Funding; Gases; Goals; Grant; Health; Home environment; Human; Human Resources; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Response; Investigation; Irrigation; Lead; Life; Link; Liquid substance; Lung; Lung diseases; Measurement; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Minority; Modeling; Outcome; Parents; Participant; Particulate; Particulate Matter; Peer Review; Phenotype; Population; Population Study; Predisposition; Prevalence; Principal Investigator; Process; Public Policy; Publishing; Recruitment Activity; Regulation; Relative (related person); Research; Research Design; Research Infrastructure; Research Personnel; Resources; Respiratory physiology; Review Literature; Seasons; Sputum; Symptoms; TNFRSF5 gene; Techniques; Time; Training; Urine; Variant; Vulnerable Populations; airway inflammation; base; comparison group; experience; field study; inner city; mortality; novel therapeutic intervention; outcome forecast; particle; policy implication; pollutant; respiratory; socioeconomics; urban area; young adult

DESCRIPTION (provided by applicant) Asthma is a chronic inflammatory disease of the lungs that is influenced by a combination of host susceptibility and environmental exposures. Particulate air pollution is a pro-inflammatory agent that has been associated with adverse health consequences. While much research has focused on outdoor exposures, the indoor environment is critical as Americans spend most of their time indoors and the investigators' preliminary data have demonstrated that indoor PM concentrations greatly exceed outdoor PM concentrations in urban homes. Based on preliminary data that suggest a strong association between coarse PM exposure and respiratory symptoms among those with non-allergic asthma, the investigators hypothesize that exposure to indoor coarse PM promotes inflammation and worsening of respiratory symptoms and lung function among individuals with non-allergic asthma. Using a study design that combines a longitudinal panel study and an exposure challenge model, the investigators will aim to provide evidence of a causal relationship between indoor coarse PM exposure and exacerbation of asthma status. In specific aim 1, they will determine the effect of indoor coarse PM exposure on asthma health by conducting an epidemiologic panel study measuring in-home PM concentrations and corresponding daily variation in lung function, asthma symptoms, and biomarkers of inflammation among inner-city minority children with non-allergic asthma. In specific aim 2, they will investigate the short-term effects of coarse PM exposure on non-allergic asthma by administering a controlled, nebulized PM challenge and measuring airway reactivity and biomarkers of inflammation. Completion of the proposed research, along with complementary training and mentorship in an outstanding and supportive environment for clinical research, will provide in-depth exposure to clinical research design, conduct, and analysis. These experiences will allow the principal investigator to become a successful, independent investigator in academic medicine. Asthma affects more than 20 million individuals in the U.S, including over 6 million children and young adults. The proposed research investigates the effect of an environmental exposure, air pollution, on this disease process. If indoor exposure to airborne PM triggers asthma exacerbations and stimulates an inflammatory response, the findings from this study may direct new therapeutic interventions and will represent an important advancement in the treatment of asthma with profound public policy implications.

描述（由申请人提供） 哮喘是肺部的一种慢性炎症性疾病，受宿主易感性和环境暴露的组合影响。 颗粒空气污染是一种促炎药，与不利的健康后果有关。 尽管大量研究集中在室外暴露上，但室内环境至关重要，因为美国人大部分时间都在室内花费，并且研究人员的初步数据表明，室内PM的浓度大大超过了城市家庭中室外PM的浓度。 基于初步数据表明，在非过敏性哮喘的人之间粗糙的PM暴露与呼吸道症状之间存在密切的关联，研究人员假设暴露于室内粗PM会促进呼吸症状的炎症和恶化的呼吸道症状和肺功能恶化，而肺部功能是非过敏性哮喘的。 使用将纵向小组研究和暴露挑战模型结合在一起的研究设计，研究人员将旨在提供室内粗PM暴露与加剧哮喘状态之间因果关系的证据。 在特定的目标1中，他们将通过进行一个流行病学小组研究来确定室内粗PM暴露对哮喘健康的影响，该研究测量肺部功能，哮喘症状，哮喘症状和炎症的生物标志物的每日相应变化，患有非过敏性哮喘的炎症。 在特定的目标2中，他们将通过管理受控的，雾化的PM挑战并测量气道反应性和炎症的生物标志物，研究粗PM暴露对非过敏性哮喘的短期影响。 拟议研究的完成，以及在临床研究的杰出和支持环境中的互补培训和指导，将为临床研究设计，行为和分析提供深入的接触。 这些经验将使首席研究人员成为一名成功，独立的学术医学研究者。 哮喘影响着美国超过2000万人，包括超过600万儿童和年轻人。 拟议的研究调查了环境暴露，空气污染对这种疾病过程的影响。 如果室内暴露于机载PM会触发哮喘病并刺激炎症反应，那么这项研究的发现可能会引导新的治疗性干预措施，并将代表对哮喘治疗的重要进步，对哮喘的影响有很大的影响。