Cardiac CT: Advanced Architectures and Algorithms

心脏 CT：先进架构和算法

基本信息

批准号：
7792699
负责人：
Bruno De Man
金额：
$ 62.49万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7792699
关键词：
Affect Algorithms American Anatomy Architecture Arts Cardiac Cardiovascular Diseases Clinical Clinics and Hospitals Data Development Diagnostic Dose Electron Beam Tomography Elements Engineering Ensure Evaluation Functional Imaging Generations Goals Health Care Costs Heart Image Knowledge Low Dose Radiation Measurement Measures Morbidity - disease rate Morphologic artifacts Motion Noise Outcome Patients Performance Phase Protocols documentation Publishing Radiation Radon Research Research Personnel Resolution Retinal Cone Rotation Sampling Scanning Scheme Source Speed Spottings Staging System Systems Analysis Technology Testing Theoretical Studies Therapeutic Tomography, Computed, Scanners Virginia Weight X-Ray Computed Tomography base design detector heart motion improved indexing innovation mortality next generation novel prototype public health relevance quantum reconstruction research study simulation social

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular diseases are pervasive with high mortality and morbidity at tremendous social and healthcare costs. There are urgent needs for significantly higher fidelity cardiac CT with substantially lower radiation dose, which is currently not possible because of technical limitations. Although cardiac CT technology has improved significantly from 16 to 320 detector rows and from single to dual source, there remain technical challenges in terms of temporal resolution, spatial resolution, radiation dose, and so on. Based on an ideal academic-industrial partnership between Virginia Tech and the GE Global Research Center (GEGR), we are motivated to advance the state-of-the-art in cardiac CT dramatically and define the next generation cardiac CT system. The overall goal of this project is to develop novel cardiac CT architectures and the associated reconstruction algorithms, and define the next-generation cardiac CT system. The specific aims are to (1) design, analyze and compare novel cardiac CT architectures with novel sources and scanning trajectories; (2) develop analytic and iterative cardiac CT reconstruction algorithms for ROI-oriented scanning and dynamic imaging for the proposed cardiac CT architectures; and (3) evaluate and validate the proposed architectures and algorithms in theoretical studies, numerical simulations, phantom experiments and observer studies. On completion of this project, we will have singled out the most promising cardiac CT architecture and algorithms to achieve 16cm coverage, 50ms temporal resolution, 20lp/cm spatial resolution, 10HU noise level, and 5mSv effective dose simultaneously for the entire examination, with detailed specifications and performance evaluation, setting the stage for prototyping a next-generation cardiac CT system in a Phase-II project. This project will make a quantum leap in cardiac CT, in the sense that our proposed cardiac CT technology will enable significantly better diagnostic performance and bring major therapeutic benefits that affect 61.8 million Americans. PUBLIC HEALTH RELEVANCE: Cardiovascular diseases are pervasive with high mortality and morbidity at tremendous social and healthcare costs. Cardiac CT technology needs major improvements to capture a fast beating heart with better image clarity at lower radiation dose. The overall goal of this project is to develop the next generation cardiac CT architecture and algorithms for significantly superior diagnostic performance and therapeutic outcomes that affect 61.8 million Americans.

描述（由申请人提供）：心血管疾病普遍存在，其死亡率和发病率很高，巨大的社会和医疗保健费用。迫切需求需要明显更高的富达心脏CT，其辐射剂量大大降低，目前由于技术限制而无法使用。尽管心脏CT技术已从16个检测器行明显改善，并且从单一探测器到双重来源，但在时间分辨率，空间分辨率，辐射剂量等方面仍然存在技术挑战。基于弗吉尼亚理工学院与GE全球研究中心（GEGR）之间理想的学术工业合作伙伴关系，我们有动力促进心脏CT中最新的CT，并定义下一代心脏CT系统。该项目的总体目标是开发新颖的心脏CT体系结构和相关的重建算法，并定义下一代心脏CT系统。具体目的是（1）设计，分析和比较新颖的心脏CT体系结构与新的来源和扫描轨迹；（2）为提出的心脏CT体系结构开发用于ROI面向ROI的扫描和动态成像的分析性心脏CT重建算法；（3）在理论研究，数值模拟，幻影实验和观察者研究中评估和验证拟议的体系结构和算法。 On completion of this project, we will have singled out the most promising cardiac CT architecture and algorithms to achieve 16cm coverage, 50ms temporal resolution, 20lp/cm spatial resolution, 10HU noise level, and 5mSv effective dose simultaneously for the entire examination, with detailed specifications and performance evaluation, setting the stage for prototyping a next-generation cardiac CT system in a Phase-II project.从某种意义上说，我们提出的心脏CT技术将使诊断性能更好，并带来影响6180万美国人的主要治疗益处，从而实现心脏CT的量子飞跃。公共卫生相关性：心血管疾病在巨大的社会和医疗保健费用上普遍存在，死亡率和发病率很高。心脏CT技术需要进行重大改进，以捕获较低辐射剂量时具有更好图像清晰度的快速跳动心。该项目的总体目标是开发下一代心脏CT体系结构和算法，以极大地影响影响6180万美国人的诊断性能和治疗结果。