The VETSA longitudinal twin study of cognition and aging

VETSA 认知与衰老纵向双胞胎研究

基本信息

批准号：
7933314
负责人：
WILLIAM S. KREMEN
金额：
$ 11.86万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7933314
关键词：
Accounting Address Adult Age Aging Aging-Related Process American Anterior Apolipoprotein E Area Automobile Driving Biological Biological Assay Biological Factors Blood Vessels Blood specimen Boston Brain Brain region Cardiovascular Diseases Cerebrum Characteristics Cognition Cognitive Cognitive aging Cognitive deficits Cohort Effect Collection Complement Craniocerebral Trauma DNA Data Data Set Dementia Development Diabetes Mellitus Disadvantaged Early Diagnosis Environmental Risk Factor Episodic memory Family Figs - dietary Financial compensation Genetic Genetic Crossing Over Genetic Models Genetic Techniques Genotype Goals Growth Habits Health Home environment Hour Hydrocortisone Hypertension Impaired cognition Individual Individual Differences Knowledge Lead Life Style Longevity Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mediating Medical Memory Memory impairment Metabolic Metabolic syndrome Methods Modeling Molecular Genetics Mydriasis Neurocognitive Neurosciences Outcome Pathway interactions Pattern Performance Personality Persons Phenotype Physiological Predictive Value Principal Investigator Process Progress Reports Psyche structure Psychophysiology Psychosocial Factor Public Health Quality of life Recording of previous events Recruitment Activity Relative (related person)Reporting Research Research Personnel Resistance Resource Allocation Resources Risk Risk Factors Sampling Secondary Prevention Sensory Short-Term Memory Shorthand Smoking Solid Staging Stress Subgroup Sum Testing Testosterone Thick Time Twin Multiple Birth Twin Studies Unconscious State Upper arm Variant Vietnam Weight Work age related age related cognitive change aged aging population base caregiving cognitive change cognitive function cognitive reserve cohort cost cost effective dehydroepiandrosterone design disability emerging adult executive function follow-up genetic analysis insight interest lifestyle factors memory process middle age mild neurocognitive impairment neuroimaging novel novel strategies physical conditioning processing speed psychologic psychosocial public health relevance resilience response social trend

项目摘要

DESCRIPTION (provided by applicant): The Vietnam Era Twin Study of Aging (VETSA) study provides a unique opportunity to examine genetic and environmental influences on early cognitive change and associated risk factors. In VETSA 2, we propose our first 5-6 year follow-up of a large, age-homogenous sample that was middle-aged (50s) at baseline. Longitudinal studies of cognitive aging have employed cohort-sequential designs with age-heterogeneous samples that are usually weighted toward older subjects. There is solid evidence of change in midlife to early old age, but because mean change does tend to be modest, increased ability to examine individual differences is key. While no single design can provide all the answers, our novel design does enhance the ability to study differences in within-individual change patterns. By focusing on midlife, our design also has increased potential to identify early predictors of cognitive decline. Moreover, we are including an objective measure of allocation of cognitive effort that will be an important indicator, even in the absence of performance changes. We will follow 720 middle-aged twin pairs (1440 individuals) 5-6 years after collection of baseline neurocognitive, biomedical, and psychosocial data. Mean age at our VETSA 2 follow-up will be 60 (57-66). Applications from 2 Principal Investigators (Kremen, UCSD; Lyons, Boston Univ.) comprise a single integrated project. Our focus is to characterize genetic and environmental influences on early age-related changes in cognitive effort and performance (Aims 1, 2), and to examine major factors that mediate or moderate those changes: APOE [Aim 3]; other biomedical risks [Aim 4]; lifestyle/psychosocial factors [Aim 5]). Aims are: 1) Characterize genetic and environmental influences on cognitive change over time (and specific component processes driving change); 2) Investigate cognitive efficiency (i.e., ratio of performance to effortful resource allocation [based on task-evoked pupillary responses]) as a key cognitive aging process; 3) Examine the relationship of APOE genotype to changes in cognitive function over time; 4) Elucidate biomedical risk factors related to cognition and identify specific health risk factors that best predict cognitive aging (with multivariate genetic models not previously used); 5) Examine lifestyle and psychosocial factors related to cognitive aging. We will obtain comprehensive assessments in multiple domains, utilize a novel approach that integrates the twin method with experimental/neuroscience approaches of parsing cognitive component processes, and use a cost-effective psychophysiological method (pupillometry) to measure cognitive effort. PUBLIC HEALTH RELEVANCE: VETSA 2 builds upon the unique resource of VETSA 1 and creates an invaluable resource for the study of change from midlife (an under-studied area) to early old age, and for understanding the interplay of biological and environmental factors that are key early predictors of declining or successful aging. The VETSA 2 project builds upon the unique resource of VETSA 1 and creates an invaluable resource for the study of midlife (an under-studied area) and for understanding the interplay of biological and environmental factors that are key determinants of successful aging.

描述（由申请人提供）：越南时代双胞胎衰老研究 (VETSA) 研究提供了一个独特的机会来检查遗传和环境对早期认知变化和相关风险因素的影响。在 VETSA 2 中，我们建议对基线时为中年（50 岁）的大型同质样本进行首次 5-6 年随访。认知衰老的纵向研究采用了队列序贯设计，其中年龄异质样本通常偏向老年受试者。有确凿的证据表明中年到老年的变化，但由于平均变化往往不大，因此提高检查个体差异的能力是关键。虽然没有单一的设计可以提供所有答案，但我们新颖的设计确实增强了研究个体内部变化模式差异的能力。通过关注中年，我们的设计还增加了识别认知能力下降的早期预测因素的潜力。此外，我们还纳入了认知努力分配的客观衡量标准，即使在没有表现变化的情况下，这也将是一个重要指标。我们将在收集基线神经认知、生物医学和社会心理数据后 5-6 年对 720 对中年双胞胎（1440 人）进行跟踪。我们的 VETSA 2 随访的平均年龄为 60 岁 (57-66)。两名主要研究人员（克雷门，加州大学圣地亚哥分校；里昂，波士顿大学）的申请构成了一个综合项目。我们的重点是表征遗传和环境对早期年龄相关的认知努力和表现变化的影响（目标 1、2），并检查介导或调节这些变化的主要因素：APOE [目标 3]；其他生物医学风险[目标 4]；生活方式/社会心理因素[目标 5]）。目标是：1）描述遗传和环境对认知随时间变化的影响（以及驱动变化的特定组成过程）； 2）研究认知效率（即绩效与努力资源分配的比率[基于任务引起的瞳孔反应]）作为关键的认知老化过程； 3) 检查APOE基因型与认知功能随时间变化的关系； 4）阐明与认知相关的生物医学风险因素，并确定最能预测认知衰老的特定健康风险因素（使用以前未使用过的多变量遗传模型）； 5）检查与认知老化相关的生活方式和社会心理因素。我们将获得多个领域的综合评估，利用一种新颖的方法，将双胞胎方法与解析认知成分过程的实验/神经科学方法相结合，并使用具有成本效益的心理生理学方法（瞳孔测量法）来测量认知努力。公共卫生相关性：VETSA 2 以 VETSA 1 的独特资源为基础，为研究从中年（研究不足的领域）到早年的变化以及了解生物和环境因素的相互作用创造了宝贵的资源。衰老或成功衰老的关键早期预测因素。 VETSA 2 项目以 VETSA 1 的独特资源为基础，为中年研究（一个尚未充分研究的领域）以及了解作为成功老龄化关键决定因素的生物和环境因素的相互作用创造了宝贵的资源。