MRI ASSESSMENT OF PALLIDOTOMY LESION PLACEMENT

苍白球切开术病变位置的 MRI 评估

• 批准号: 7724442
• 负责人: JEFF Michael BRONSTEIN
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724442
• 关键词: Agreement; Computer Retrieval of Information on Scientific Projects Database; Disease; Dyskinetic syndrome; Funding; Grant; Institution; Lesion; Magnetic Resonance Imaging; Motor; Numbers; Operative Surgical Procedures; Parkinson Disease; Patients; Placement; Postoperative Period; Refractory; Reporting; Research; Research Personnel; Resources; Source; Symptoms; United States National Institutes of Health; patient oriented; radiofrequency; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MRI Assessment of Pallidotomy Lesion Placement and Post-operative Localization in Parkinson's Disease In recent years, the use of radiofrequency ventroposterior pallidotomy (VPP) as a symptomatic treatment for the medically refractory motor symptoms of Parkinson¿s disease (PD) has been gaining widespread acceptance. A number of centers have reported significant improvements in controlling disabling dyskinesias, on/off fluctuations and other motor symptoms in patients with idiopathic PD (Baron et al., 1996; Dogali et al., 1995; Iacono et al., 1995; Johansson et al., 1997; Lang et al., 1997; Laitinen et al., 1992a; Laitinen et al., 1992b; Lozano et al., 1995; Uitti et al., 1997). Although there is a general agreement that VPP is helpful for many patients, results vary considerably between patients and centers performing the operation. One reason for this variability is likely due to differences in lesion placement and size.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 MRI评估帕金森氏病中颗粒切开病变的位置和术后定位 近年来，使用射频腹膜骨术（VPP）作为帕金森病（PD）的医学难治性运动症状（PD）的症状治疗已获得宽度的接受度。许多中心报告了特发性PD患者控制残疾失调，开/关节症状以及其他运动症状的显着改善（Baron等，1996; Dogali et al。，1995; Iacono等，1995; 1995; 1995; 1995; 1995; Johansson et al。 1992b;尽管有一个普遍的同意，即VPP对许多患者有帮助，但在执行手术的患者和中心之间的结果谨慎。这种变异性的原因之一可能是由于病变的位置和大小的差异。