MRI ASSESSMENT OF PALLIDOTOMY LESION PLACEMENT

苍白球切开术病变位置的 MRI 评估

• 批准号: 8363459
• 负责人: JEFF Michael BRONSTEIN
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363459
• 关键词: Agreement; Disease; Dyskinetic syndrome; Funding; Grant; Lesion; Magnetic Resonance Imaging; Modeling; Motor; National Center for Research Resources; Parkinson Disease; Patients; Postoperative Period; Principal Investigator; Refractory; Reporting; Research; Research Infrastructure; Resources; Source; Symptoms; United States National Institutes of Health; computational anatomy; cost; operation; patient oriented; radiofrequency

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MRI Assessment of Pallidotomy Lesion Placement and Post-operative Localization in Parkinson's Disease In recent years, the use of radiofrequency ventroposterior pallidotomy (VPP) as a symptomatic treatment for the medically refractory motor symptoms of Parkinson¿s disease (PD) has been gaining widespread acceptance. A number of centers have reported significant improvements in controlling disabling dyskinesias, on/off fluctuations and other motor symptoms in patients with idiopathic PD (Baron et al., 1996; Dogali et al., 1995; Iacono et al., 1995; Johansson et al., 1997; Lang et al., 1997; Laitinen et al., 1992a; Laitinen et al., 1992b; Lozano et al., 1995; Uitti et al., 1997). Although there is a general agreement that VPP is helpful for many patients, results vary considerably between patients and centers performing the operation. One reason for this variability is likely due to differences in lesion placement and size.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 MRI评估帕金森氏病中颗粒切开病变的位置和术后定位 近年来，使用射频腹膜骨术（VPP）作为帕金森病（PD）的医学难治性运动症状（PD）的症状治疗已获得宽度的接受度。许多中心报告了特发性PD患者控制残疾失调，开/关节症状以及其他运动症状的显着改善（Baron等，1996; Dogali et al。，1995; Iacono等，1995; 1995; 1995; 1995; 1995; Johansson et al。 1992b;尽管有一个普遍的同意，即VPP对许多患者有帮助，但在执行手术的患者和中心之间的结果谨慎。这种变异性的原因之一可能是由于病变的位置和大小的差异。