COLLAGEN STRUCTURE UNDER TENSION W/ DEPTH AND AGE VARIATION IN BOVINE CARTILAGE

牛软骨中处于张力下的胶原蛋白结构随深度和年龄的变化

• 批准号: 7722450
• 负责人: Robert L Sah
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722450
• 关键词: Age; Biomechanics; Bos taurus; Bovine Cartilage; Cartilage; Cartilage Matrix; Cattle; Collagen; Collagen Fibril; Computer Retrieval of Information on Scientific Projects Database; Depth; Funding; Grant; Institution; Knee; Mechanics; Personal Satisfaction; Property; Research; Research Personnel; Resources; Source; Structure; Surface; Tissues; United States National Institutes of Health; Variant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cartilage matrix components have been shown to vary in content and organization with age and vertical depth from the articular surface. This structural variation has been correlated to the anisotropic mechanical properties of cartilage. However, most of the structural studies of collagen have been performed on unstressed cartilage, and any changes that occur in the collagen structure during load have not been well-characterized. Determining the effect of tension on collagen fibril structure would help elucidate how cartilage tissue structure relates to its biomechanical function. The objective of this study is to elucidate changes in collagen structure in tension with varying depths and ages of bovine knee cartilage.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 软骨基质组件已显示出与关节表面的年龄和垂直深度的内容和组织不同。 这种结构变化与软骨的各向异性机械性能有关。 但是，胶原蛋白的大多数结构研究都是在无重大软骨上进行的，并且在负载期间胶原蛋白结构中发生的任何变化都没有得到充分表征。 确定张力对胶原原纤维结构的影响将有助于阐明软骨组织结构与其生物力学功能的关系。 这项研究的目的是阐明与牛膝膝部软骨的深度和年龄不同的张力中胶原蛋白结构的变化。