2007 Protein Transport Across Membranes Gordon Conference

2007 年蛋白质跨膜转运戈登会议

• 批准号: 7273965
• 负责人: Carla M Koehler
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273965
• 关键词: Academia; Address; Area; Bacteria; Biochemical Genetics; Biology; Cell membrane; Cells; Complex; Disease; Employee Strikes; Eukaryotic Cell; Future; Goals; Government; Human; Industry; Infection; Inherited; Italy; Lateral; Lipid Bilayers; Lipids; Localized; Location; Maintenance; Membrane; Membrane Proteins; Mitochondria; Organelles; Participant; Permeability; Postdoctoral Fellow; Protein translocation; Proteins; Range; Regulation; Request for Proposals; Research; Role; Scientist; Site; Structure; Students; System; Therapeutic; Virus; Work; novel; peroxisome; posters; protein transport; structural genomics; symposium

DESCRIPTION (provided by applicant): This proposal requests support for the 2nd Protein Transport Across Cell Membranes Gordon Research Conference (GRC), to be held June 10-15, 2007 at GRC site Il Ciocco in Italy. This new meeting will focus on the latest discoveries that enhance our understanding of the mechanisms by which proteins are transported across or integrated into membranes in eukaryotic cells, bacteria and organelles (e.g., mitochondria and peroxisomes). Since >25% of all proteins in all cells must cross at least one membrane to be correctly localized, protein translocation is one of the most fundamental problems in biology. The conference will address a wide range of topics including 1) the selection of proteins for translocation and their targeting to translocation sites, 2) the structure, function and assembly of translocation complexes and insertases, 3) reverse or retro-translocation, 4) constraints on the folded state of translocation substrates, 5) the maintenance of permeability barriers, 6) lateral transfer of membrane proteins into lipid bilayers, 7) the role of lipids in protein translocation and membrane protein integration, 8) the role of energy in protein transport, 9) the regulation of protein translocation and 10) novel protein translocation mechanisms. One of the main goals of this conference is to promote interactions among scientists who use diverse biochemical, genetic, genomic and structural approaches to understand fundamental mechanisms of protein transport across membranes. In addition, this conference will expose junior scientists to a broad range of experimental systems and problems in which understanding protein translocation and assembly is critical. This conference was established primarily to compensate for a striking dearth of formal opportunities for scientists who work on different but conceptually or mechanistically related aspects of protein translocation to meet and exchange ideas. The participants at the Protein Transport Across Cell Membranes Gordon Conference will include the leaders in the field, drawn from academia, government and industry, as well as more junior scientists, including many graduate students and postdoctoral fellows who represent the future in this area. A major use of the support sought in this application is to assist such junior scientists to participate in the meeting. The Gordon Conferences are organized to maximize opportunities for discussion and for the presentation of the latest findings in the field, with poster sessions occurring every afternoon and discussion periods after each formal session. This conference brings together scientists to discuss basic mechanisms of how a cell assembles and how proteins reach their correct location. This conference will discuss topics related to inherited diseases as well as ways in with bacteria and viruses may cause infection in humans. As a result, this conference leads to an increased understanding in the cause of disease and potential therapeutic approaches.

说明（由申请人提供）：本提案请求支持将于 2007 年 6 月 10 日至 15 日在意大利 Il Ciocco 举行的第二届蛋白质跨细胞膜转运戈登研究会议 (GRC)。这次新会议将重点关注最新发现，这些发现增强了我们对真核细胞、细菌和细胞器（例如线粒体和过氧化物酶体）中蛋白质跨膜转运或整合到膜中的机制的理解。由于所有细胞中超过 25% 的蛋白质必须穿过至少一层膜才能正确定位，因此蛋白质易位是生物学中最基本的问题之一。会议将讨论广泛的主题，包括 1) 用于易位的蛋白质的选择及其对易位位点的靶向，2) 易位复合物和插入酶的结构、功能和组装，3) 反向或逆向易位，4) 限制易位底物的折叠状态，5) 通透性屏障的维持，6) 膜蛋白横向转移到脂质双层中，7) 脂质在蛋白质易位和膜蛋白整合中的作用，8)蛋白质运输中的能量，9）蛋白质易位的调节和10）新颖的蛋白质易位机制。本次会议的主要目标之一是促进科学家之间的互动，他们使用不同的生化、遗传、基因组和结构方法来了解蛋白质跨膜运输的基本机制。此外，本次会议将使初级科学家接触到广泛的实验系统和问题，其中了解蛋白质易位和组装至关重要。这次会议的成立主要是为了弥补那些致力于蛋白质易位的不同但概念或机制相关方面的科学家见面和交流想法的正式机会的严重缺乏。蛋白质跨细胞膜转运戈登会议的参与者将包括来自学术界、政府和工业界的该领域的领导者，以及更多的初级科学家，其中包括许多代表该领域未来的研究生和博士后研究员。本申请寻求支持的一个主要用途是协助这些初级科学家参加会议。戈登会议的组织目的是为了最大限度地增加讨论和展示该领域最新发现的机会，每天下午举行海报会议，并在每次正式会议后进行讨论。 这次会议汇集了科学家们，讨论细胞如何组装以及蛋白质如何到达正确位置的基本机制。本次会议将讨论与遗传性疾病以及细菌和病毒可能导致人类感染的方式相关的主题。因此，这次会议加深了人们对疾病原因和潜在治疗方法的了解。