FASEB conference on Assembly of the Mitochondrial Respiratory Chain

FASEB 线粒体呼吸链组装会议

• 批准号: 7328120
• 负责人: Dennis R. Winge
• 金额: $ 1.25万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7328120
• 关键词: Aging-Related Process; Apoptosis; Area; Arizona; Ataxia; Biochemical; Biogenesis; Biology; Birth; Blindness; Cardiomyopathies; Communication; Complex; Crista ampullaris; Cytoplasm; Defect; Diabetes Mellitus; Disease; Dystonia; Faculty; Functional disorder; Funding; Glean; Goals; Human; Incidence; Individual; Inherited; Lead; Liver diseases; Metabolic; Minority; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Morphology; Myoclonus; Neurodegenerative Disorders; Nuclear; Oral; Organelles; Pathway interactions; Patients; Physiological Processes; Play; Production; Protein Import; Protein Sortings; Range; Regulation; Research; Research Personnel; Resort; Respiration; Respiratory Chain; Role; Scientist; Seizures; Seminal; Sideroblastic Anemia; Structure; Students; Thermogenesis; Time; Woman; Work; clinical phenotype; cofactor; deafness; design; human disease; insight; interest; iron metabolism; lipid metabolism; membrane biogenesis; mitochondrial dysfunction; posters; respiratory; symposium

DESCRIPTION: This proposal seeks funds to support the 2007 FASEB Research Conference on Assembly of the Mitochondrial Respiratory Chain. The principal objective is to inaugurate a new FASEB conference on a rapidly expanding area of mitochondrial biology. The meeting will bring together scientists, ranging from established investigators to graduate students, to promote the exchange of scientific ideas among scientists interested in diverse aspects of mitochondrial biology and mitochondrial dysfunction in human disease, with a view to encouraging collaborative approaches and cross-field stimulation. Funds are requested to support trainees and junior faculty who would benefit from attendance at this conference. The timing of this conference is significant, as interest in mitochondrial biology and dysfunction has surged. Seminal advances have occurred in recent years on physiological processes within the organelle such as the dynamics of morphology, protein import into sub-compartments, identification of supercomplexes, and interorganelle communication. Insight has been gleaned from patients with cardiomyopathy, hepatopathy, and neurodegenerative disease on assembly and regulation. The biochemical defect in the majority of the patients results from a defect in assembly and this can lead to a myriad of clinical phenotypes ranging from ataxia, seizures, blindness, myoclonus, dystonia, sideroblastic anemia, deafness, and diabetes. An understanding of the structure, assembly and function of the respiratory chain is thus a highly significant topic. Sessions will deal with the structure and dynamics of the mitochondrion, the organization of respiratory chain components, transcriptional and translational regulatory circuits controlling mitochondrial biogenesis and function, mitochondrial-nuclear and mitochondrial- cytoplasm cross talk, mitochondrial protein sorting and its role in disease, assembly of individual respiratory complexes, cofactor biogenesis and cristae formation. The novelty of the Assembly of the Mitochondrial Respiratory Chain lies in the unique focus on biogenesis of the respiratory chain components and respiratory dysfunction in humans. No other meeting has attempted this. The 2007 FASEB conference Assembly of the Mitochondrial Respiratory Chain is designed to promote the exchange of scientific ideas among scientists interested in diverse aspects of mitochondrial respiration and biogenesis of the respiratory complexes. Interest in mitochondrial biology has surged in recent years, so the timing of this conference is significant in highlighting advances made in mitochondrial dynamics and morphology, inner membrane biogenesis and inter-organelle communication. Mitochondria play a key role in apoptosis, lipid metabolism, energy production, thermogenesis, iron metabolism and other catabolic and anabolic pathways. Mitochondrial dysfunction contributes to numerous inherited and acquired human diseases and the ageing process. Insight has been gleaned from patients with cardiomyopathy, hepatopathy, and neurodegenerative disease on assembly and regulation. Defects in assembly of the respiratory chain can lead to a myriad of clinical phenotypes ranging from ataxia, seizures, blindness, myoclonus, dystonia, sideroblastic anemia, deafness, and diabetes. Thus, an understanding of the structure, assembly and function of the respiratory chain is thus a highly significant topic. The novelty of the Assembly of the Mitochondrial Respiratory Chain lies in the unique focus on biogenesis of the respiratory chain components and respiratory dysfunction in humans. No other meeting has attempted this.

描述：本提案寻求资金支持 2007 年 FASEB 线粒体呼吸链组装研究会议。主要目标是就快速扩展的线粒体生物学领域召开新的 FASEB 会议。会议将汇集从资深研究人员到研究生的科学家，以促进对线粒体生物学和人类疾病中线粒体功能障碍的各个方面感兴趣的科学家之间的科学思想交流，以鼓励合作方法和跨领域刺激。请求资金支持学员和初级教师，他们将从参加本次会议中受益。这次会议的时机意义重大，因为人们对线粒体生物学和功能障碍的兴趣激增。近年来，细胞器内的生理过程取得了重大进展，例如形态动力学、蛋白质输入子区室、超级复合物的识别和细胞器间通讯。我们从患有心肌病、肝病和神经退行性疾病的患者身上收集到了关于组装和调节的见解。大多数患者的生化缺陷是由组装缺陷引起的，这可能导致多种临床表型，包括共济失调、癫痫发作、失明、肌阵挛、肌张力障碍、铁粒幼细胞贫血、耳聋和糖尿病。因此，了解呼吸链的结构、组装和功能是一个非常重要的课题。会议将讨论线粒体的结构和动力学、呼吸链组件的组织、控制线粒体生物发生和功能的转录和翻译调节电路、线粒体-核和线粒体-细胞质串扰、线粒体蛋白质分选及其在疾病、组装中的作用个体呼吸复合物、辅因子生物发生和嵴形成。线粒体呼吸链组装的新颖性在于对呼吸链成分的生物发生和人类呼吸功能障碍的独特关注。没有其他会议尝试过这一点。 2007 年 FASEB 大会线粒体呼吸链大会旨在促进对线粒体呼吸和呼吸复合体生物发生的各个方面感兴趣的科学家之间的科学思想交流。近年来，人们对线粒体生物学的兴趣激增，因此这次会议的时机对于强调线粒体动力学和形态、内膜生物发生和细胞器间通讯方面取得的进展具有重要意义。线粒体在细胞凋亡、脂质代谢、能量产生、产热、铁代谢以及其他分解代谢和合成代谢途径中发挥关键作用。线粒体功能障碍导致许多遗传性和后天性人类疾病和衰老过程。我们从患有心肌病、肝病和神经退行性疾病的患者身上收集到了关于组装和调节的见解。呼吸链组装缺陷可导致多种临床表型，包括共济失调、癫痫、失明、肌阵挛、肌张力障碍、铁粒幼细胞贫血、耳聋和糖尿病。因此，了解呼吸链的结构、组装和功能是一个非常重要的课题。线粒体呼吸链组装的新颖性在于对呼吸链成分的生物发生和人类呼吸功能障碍的独特关注。没有其他会议尝试过这一点。