Mitochondria and Oxidative Stress in Neurodegenerative Disorders

神经退行性疾病中的线粒体和氧化应激

• 批准号: 7327395
• 负责人: M FLINT BEAL
• 金额: $ 4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7327395
• 关键词: Academy; Address; Aging; Alzheimer' s Disease; Arts; Chairperson; Clinical; Code; Development; Disease; Doctor of Philosophy; Electronics; Fostering; Functional disorder; Genes; Genetic Transcription; Goals; Huntington Disease; Impairment; Medical; Mitochondria; Modification; Nervous system structure; Neurodegenerative Disorders; Neurology; Neurosciences; New York; Organelles; Oxidants; Oxidative Stress; Parkinson Disease; Printing; Research Institute; Research Personnel; Role; Science; Signal Transduction; Students; Subcellular structure; Therapeutic; Translational Research; Universities; age related; college; day; design; improved; insight; macromolecule; professor; programs; symposium

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a major 3 1/2-day conference entitled "Mitochondria and Oxidative Stress in Neurodegenerative Disorders" to be held September 26-29, 2007 at the New York Academy of Sciences, New York, NY. The conference is being organized by Gary E. Gibson, PhD, Professor of Neuroscience, Weill Medical College of Cornell University, and Burke-Cornell Medical Research Institute, Rajiv R. Ratan, MD, PhD, Burke Professor of Neurology and Neuroscience, Weill Medical College of Cornell University, Executive Director, Burke-Cornell Medical Research Institute, and M. Flint Beal, MD, Professor and Chairman, Department of Neurology and Neuroscience, Weill Medical College of Cornell University. Our understanding of the interaction of mitochondria with other cellular organelles, with transcription and in the ability to detect oxidative modification of macromolecules has improved significantly in past decade. Moreover the roles of mitochondria and oxidative stress are better defined in the pathophysiology of neurodegenerative disorders. The goal of the meeting is to determine what we need to know to move towards better therapies. This conference will combine basic, clinical and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. Specific objectives of this conference are to: 1) develop a better understanding of the role of mitochondrial in the nervous system; 2) discuss the involvement of mitochondria in specific neurodegenerative disorders; 3) address therapeutic approaches to treating these diseases; 4) allow students, fellows and junior investigators to be involved in the program and to foster their ability to form networks amongst themselves and with more senior investigators and 5) disseminate the proceedings by print and electronic means so that a wider audience can benefit from the insights shared. The age-related onset and progression of neurodegenerative disorders such as Alzheimer's disease, Huntington's disease and Parkinson's disease underscores a relationship between aging, mitochondrial impairment and oxidative stress. The development of effective therapies requires that we understand mitochondrial function, structure, intracellular and intercellular oxidant signaling, oxidative stress and the control of genes that code mitochondrial components. This conference will provide a forum for discussion of the state-of-the-art in oxidative stress and its relationship to neurodegenerative diseases.

描述（由申请人提供）：纽约科学院 (NYAS) 计划于 2007 年 9 月 26 日至 29 日在纽约举行一次为期 3 1/2 天的大型会议，题为“神经退行性疾病中的线粒体和氧化应激”科学院，纽约州纽约市。本次会议由康奈尔大学威尔医学院和伯克-康奈尔医学研究所神经科学教授 Gary E. Gibson 博士、威尔医学院伯克神经病学和神经科学教授 Rajiv R. Ratan 医学博士、哲学博士主办康奈尔大学学院、伯克-康奈尔医学研究所执行主任，以及康奈尔大学威尔医学院神经病学和神经科学系教授兼系主任 M. Flint Beal 医学博士。在过去的十年中，我们对线粒体与其他细胞器的相互作用、转录以及检测大分子氧化修饰的能力的理解有了显着提高。此外，线粒体和氧化应激的作用在神经退行性疾病的病理生理学中得到了更好的定义。会议的目标是确定我们需要了解什么以寻求更好的治疗方法。本次会议将在一个论坛上结合基础、临床和转化研究，旨在提供有关线粒体功能及其与年龄相关神经退行性疾病及其治疗的关系的最新信息。本次会议的具体目标是：1）更好地了解线粒体在神经系统中的作用； 2）讨论线粒体在特定神经退行性疾病中的参与； 3）提出治疗这些疾病的治疗方法； 4) 允许学生、研究员和初级研究人员参与该计划，并培养他们在彼此之间以及与更高级的研究人员建立网络的能力； 5) 通过印刷和电子方式传播会议记录，以便更广泛的受众能够从该计划中受益分享了见解。阿尔茨海默病、亨廷顿病和帕金森病等神经退行性疾病的发病和进展与年龄相关，强调了衰老、线粒体损伤和氧化应激之间的关系。有效疗法的开发需要我们了解线粒体的功能、结构、细胞内和细胞间氧化信号、氧化应激以及编码线粒体成分的基因的控制。本次会议将为讨论氧化应激的最新进展及其与神经退行性疾病的关系提供一个论坛。