Integrated Biobanking Shared Resource

综合生物样本库共享资源

基本信息

批准号：
10239119
负责人：
Michael M Ittmann
金额：
$ 28.8万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10239119
关键词：
Acquired Immunodeficiency Syndrome Animal Model Animals Basic Science Biological Assay Blood Cancer Center Cancer Center Support Grant Cancer Model Clinical Clinical Data Collaborations Collection Comprehensive Cancer Center Consent Consultations DNA Data Databases Development Enrollment Ensure Epidemiology Etiology Formalin Frozen Sections Funding Future Genomics Histology Histopathology Hospitals Human Human Resources Image Analysis Immunohistochemistry Informed Consent Investigation Maintenance Malignant Neoplasms Medicine Metagenomics National Cancer Institute Normal tissue morphology Paraffin Embedding Pathologic Pathologist Pathology Peripheral Blood Mononuclear Cell Play Population Research Population Sciences Prevention Proteomics Questionnaires Research Research Activity Research Personnel Resource Sharing Resources Risk Factors Role Scanning Science Secure Services Slide Specimen Stains Structure Technology Tissue Embedding Tissue Microarray Tissues Training Translational Research Urine Venous blood sampling anticancer research base biobank cancer specimen resource cancer therapy cell preparation clinical care college epidemiologic data experience follow-up histological stains human tissue in vivo laser capture microdissection metabolomics microbiome mouse model multidisciplinary multiplexed imaging operation optimal treatments patient derived xenograft model programs tissue processing transcriptomics translational scientist tumor

项目摘要

PROJECT SUMMARY: Integrated Biobanking Shared Resource (IBSR) The purpose of the Integrated Biobanking Shared Resource is to provide access to biospecimens by coordinated general and targeted biospecimen acquisition along with relevant expertise and technical resources to enhance basic, translational and clinical cancer biospecimen-based research activities at the Dan L. Duncan Comprehensive Cancer Center. Access to such resources is critical for biospecimen-based cancer investigations. This Shared Resource (SR) is a merger of the prior Human Tissue Acquisition and Pathology (HTAP) and the Population Sciences Biorepository (PSB) SRs into a single Integrated Biobanking SR (IBSR). This is a natural outgrowth of the close working relationship of the HTAP and PSB SRs over many years. Merger of HTAP and PSB SRs will allow us to further integrate our operations within a common management structure. The Shared Resource personnel have extensive experience in pathology, epidemiology, biospecimen acquisition and processing, bank maintenance and distribution. In addition, personnel are trained in the various technical services offered including peripheral blood mononuclear cell preparation, DNA extraction, routine histology services, frozen sections, tissue microarray construction, immunohistochemistry, tissue microarray scanning, and multiplex image analysis. We also provide pathology consultation by expert pathologists for both human tissue specimens and mouse models, and risk factor questionnaire development and collection.

项目摘要：集成的生物库共享资源（IBSR）集成生物群共享资源的目的是提供对生物测量的访问协调的一般和有针对性的生物循环收购以及相关的专业知识和技术为了增强DAN的基础，转化和临床癌症生物测量研究活动的资源 L. Duncan综合癌症中心。获取此类资源对于基于生物的癌症至关重要调查。这种共享资源（SR）是先前的人体组织获取和病理的合并（HTAP）和人口科学生物座位（PSB）SRS中的单个综合生物群体（IBSR）。这是多年来HTAP和PSB SR紧密工作关系的自然产物。 HTAP和PSB SRS的合并将使我们能够将运营进一步整合到共同的管理中结构。共享资源人员在病理学，流行病学，生物环境获取和处理，银行维护和分配。此外，人员接受培训在提供的各种技术服务中，包括外周血单核细胞制备，DNA 提取，常规组织学服务，冷冻部分，组织微阵列结构，免疫组织化学，组织微阵列扫描和多重图像分析。我们还提供专家的病理咨询人体组织标本和小鼠模型的病理学家以及风险因素问卷开发和收集。