COMPUTATIONAL MOLECULAR BIOMEDICAL FRAMEWORK ON THE GRID

网格上的计算分子生物医学框架

• 批准号: 7722340
• 负责人: DAVID L ABRAMSON
• 金额: $ 1.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722340
• 关键词: Behavior; Biological Process; Biophysics; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Funding; Genetic; Grant; Institution; Ligands; Molecular; Pharmacologic Substance; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; design; interest; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research in genetics and biophysics shows how much scientific fields can thrive when original data are readily available in public databases. A well-known example is the storage of experimental three-dimensional structures in the Protein Databank (PDB). Unfortunately, in theoretical chemistry this exchange of information is much less developed. We are particularly interested in the behavior of ligands in proteins, which is of invaluable importance for the understanding of biological processes and the design of pharmaceutical agents.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 遗传学和生物物理学的研究表明，当公共数据库中很容易获得原始数据时，科学领域可以蓬勃发展。一个众所周知的例子是蛋白质数据库（PDB）中实验三维结构的存储。不幸的是，在理论化学中，这种信息交换的发展少得多。我们对配体在蛋白质中的行为特别感兴趣，这对于理解生物过程和制药剂的设计至关重要。