BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

酒精神经适应的行为基因组学

• 批准号: 7958543
• 负责人: KATHLEEN A GRANT
• 金额: $ 6.04万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958543
• 关键词: Alcohols; Ataxia; CCL18 gene; Computer Retrieval of Information on Scientific Projects Database; Development; Dose; Ethanol; Funding; Genes; Goals; Grant; Head; Heritability; Hormonal; Human; Institution; Macaca mulatta; Measures; Monkeys; Motor; Primates; Research; Research Personnel; Research Project Grants; Resources; Self Administration; Source; United States National Institutes of Health; alcohol effect; alcohol response; alcohol use disorder; behavioral genomics; design; human subject; neuroadaptation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 最初的敏感性及其与人类学科研究中酒精使用障碍发展的关系最常通过受试者反应，协调性运动或荷尔蒙反应来衡量[Farren and Tipton，1999;希思，1999年； Schuckit，2001年]。有了这些措施，据估计，人类对酒精的反应低于0.4至06之间。朱迪·卡梅伦（Judy Cameron）博士领导的研究项目旨在确定在乙醇naquys中，乙醇中的乙醇固定在乙醇中，这项研究是在这项研究中，这项研究是在这项研究中，这项研究是在这项研究中，这项研究是在这项研究中均设计了元素的元素，该乙醇是在年轻的介绍中，在年轻的介绍中，乙醇诱发了共济失调的遗传力。自2004年以来一直通过PARC资助的乙醇的肠毒性作用。我们的目标是确定对乙醇的二毒性作用的初始敏感性是否可以预测猴子成年后酒精自我给药的程度。