Symposium on Data Integration from the Monkey Model of Alcohol Drinking

猴子饮酒模型数据整合研讨会

• 批准号: 8837787
• 负责人: KATHLEEN A GRANT
• 金额: $ 2.19万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8837787
• 关键词: Abstinence; Address; Age; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Anxiety; Autopsy; Behavioral; Chronic; Communities; Consensus; Data; Data Set; Discipline; Endocrine; Endocrinologist; Feedback; Future; Genetic; Genomics; Goals; Health; Human; Image; Immunologist; Informatics; Knowledge; Macaca fascicularis; Macaca mulatta; Modeling; Molecular; Monkeys; Nature; Neurosciences; Organ; Outcome; Pathology; Procedures; Process; Protocols documentation; Research Priority; Resources; Risk; Risk Factors; Rodent; Scientist; Self Administration; Self-Administered; Strategic Planning; Stress; Structure; System; Testing; Time; Tissues; alcohol exposure; alcohol research; body system; cohort; data integration; design; in vivo; meetings; multidisciplinary; novel; public health relevance; sex; symposium

DESCRIPTION (provided by applicant): The primary goal of the conference is to customize an informatic platform to produce new knowledge in the long-term adaptation of multiple organ systems to chronic, excessive, voluntary alcohol self-administration in order to understand the dynamic contributions of these adaptations to adverse biomedical outcomes. We will accomplish this goal by bringing together scientists that have collaborated and used the resources within the Monkey Alcohol Tissue Research Resource (www.MATRR.com) and the Integrative Neuroscience Initiative on Alcoholism (INIA): Stress, anxiety and excessive alcohol (www.INIAstress.org). The data sets that have been generated on the tissue to date are cross-disciplinary and cross-institutional, but all have the common factor of the same alcohol self-administration procedure, same antecedent and subsequent longitudinal genomic, endocrine, imaging and behavioral protocols. Indeed, the monkey model of alcohol self-administration has produced novel data for hypothesis testing relating the risk for and consequences of alcohol consumption and serve to bi-directionally bridge the gap between rodent and human studies. The symposium will focus on datasets generated from two species of monkeys (cynomolgus and rhesus macaques), particularly the rapid expansion of the data from different disciplines in the past 3 years. An outcome of the meeting will be to further understand from the users how to develop an informatics system that can accept summarized experimental outcomes across many disciplines and experimental protocols in order to integrate the analysis of genomic, genetic and phenotypic information and produce a comprehensive picture of dynamic interactions of risk factors, alcohol exposure, and adverse biomedical outcome. The gathering of geneticists, molecular biologists, neurophysiologists, endocrinologists, immunologists, osteopathologists, in vivo imagers, and behaviorists for a two day meeting will efficiently accomplish this goal.

描述（由申请人提供）：会议的主要目标是定制一个信息平台，以产生多器官系统长期适应慢性、过量、自愿饮酒的新知识，以了解其动态贡献这些对不良生物医学结果的适应。我们将通过汇集科学家合作并使用猴子酒精组织研究资源 (www.MATRR.com) 和酗酒综合神经科学计划 (INIA) 内的资源来实现这一目标：压力、焦虑和过量饮酒 (www.MATRR.com)。 INIAstress.org）。迄今为止在组织上生成的数据集是跨学科和跨机构的，但都具有相同的酒精自我管理程序、相同的前因和后续纵向基因组、内分泌、成像和行为方案的共同因素。事实上，自我饮酒的猴子模型已经为与饮酒的风险和后果相关的假设检验提供了新的数据，并有助于双向弥合啮齿动物和人类研究之间的差距。研讨会将重点关注两种猴子（食蟹猴和恒河猴）生成的数据集，特别是过去三年中不同学科数据的快速扩展。会议的一个成果将是让用户进一步了解如何开发一个信息学系统，该系统可以接受跨多个学科和实验方案的总结实验结果，以便整合基因组、遗传和表型信息的分析，并生成一个全面的图景。危险因素、酒精暴露和不良生物医学结果的动态相互作用。遗传学家、分子生物学家、神经生理学家、内分泌学家、免疫学家、骨病理学家、体内成像师和行为学家齐聚一堂，召开为期两天的会议，将有效地实现这一目标。