MONKEY ALCOHOL TISSUE RESEARCH RESOURCE (MATRR)

猴子酒精组织研究资源 (MATRR)

• 批准号: 8357856
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357856
• 关键词: Accounting; Affect; Alcohol consumption; Alcoholism; Alcohols; Animals; CNS processing; Chronic; Communities; Data; Development; Disease; Endocrine; Ensure; Ethanol; Funding; Genetic; Grant; Heavy Drinking; Hepatic; Housing; Human; Macaca mulatta; Medical; Monkeys; National Center for Research Resources; Organ; Primates; Principal Investigator; Protocols documentation; Publications; Research; Research Infrastructure; Resources; Risk; Rodent; Self Administration; Source; Staging; Testing; Time; Tissue Banking; Tissue Banks; Tissues; United States National Institutes of Health; alcohol exposure; alcohol research; animal tissue; base; brain behavior; cost; drinking; forest; longitudinal design; nonhuman primate; novel; tool; vervet

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Excessive alcohol ingestion, occasionally or chronically, is co-morbid with medical disorders affecting the brain and behavior as well as other organ damage. Much of what is known about risk for and the consequence of heavy alcohol consumption, including mechanisms of organ damage, is derived from rodent studies or retrospective human accounts. The Monkey Alcohol Tissue Research Resource (MATRR) is a unique post-mortem tissue bank to ensure tissue from animals chronically drinking alcohol, as well as their related drinking and genetic information, is available to the wider alcohol research community insuring reduced numbers of animals used in research. The tissue is derived from a standard protocol of ethanol self-administration in three species of monkeys housed at ONPRC (rhesus and cynomolgus) and Wake Forest (vervet). This resource will provide novel data for hypothesis testing relating the risk for and consequences of alcohol consumption and serve to bi-directionally bridge the gap between rodent and human studies. The basis of the MATRR is that non human primates, specifically monkeys, show a range of drinking excessive amounts of alcohol (3.0 g/kg or a 12 drink equivalent/day) over long periods of time (12-30 months) with concomitant pathological changes in endocrine, hepatic and central nervous system (CNS) processes. These longitudinal designs span "stages of drinking" from ethanol-naive to early alcohol exposure to chronic abuse. The demand for, and the quality of, the tissues are already high as reflected in the number of requests and publications. Nevertheless, this resource needs further development in order to fulfill its potential as a cutting edge translational tool in alcoholism research.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 偶尔或长期过量饮酒会与影响大脑和行为以及其他器官损伤的医学疾病同时发生。关于大量饮酒的风险和后果的大部分了解，包括器官损伤的机制，都来自啮齿动物研究或回顾性人类记录。猴子酒精组织研究资源 (MATRR) 是一个独特的死后组织库，旨在确保长期饮酒动物的组织及其相关饮酒和遗传信息可供更广泛的酒精研究界使用，从而确保减少使用的动物数量在研究中。 该组织源自对 ONPRC（恒河猴和食蟹猴）和维克森林大学（黑长尾猴）饲养的三种猴子进行乙醇自我给药的标准方案。该资源将为有关饮酒风险和后果的假设检验提供新颖的数据，并有助于双向弥合啮齿动物和人类研究之间的差距。 MATRR 的基础是，非人类灵长类动物，特别是猴子，表现出一系列长期（12-30 个月）过量饮酒（3.0 g/kg 或 12 份饮料当量/天），并伴有病理学症状。内分泌、肝脏和中枢神经系统（CNS）过程的变化。这些纵向设计跨越了从从未接触过乙醇到早期接触酒精到长期滥用酒精的“饮酒阶段”。正如请求和出版物的数量所反映的那样，对纸巾的需求和质量已经很高。然而，该资源需要进一步开发，以发挥其作为酗酒研究前沿转化工具的潜力。