MONKEY ALCOHOL TISSUE RESEARCH RESOURCE (MATRR)

猴子酒精组织研究资源 (MATRR)

• 批准号: 8357856
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357856
• 关键词: Accounting; Affect; Alcohol consumption; Alcoholism; Alcohols; Animals; CNS processing; Chronic; Communities; Data; Development; Disease; Endocrine; Ensure; Ethanol; Funding; Genetic; Grant; Heavy Drinking; Hepatic; Housing; Human; Macaca mulatta; Medical; Monkeys; National Center for Research Resources; Organ; Primates; Principal Investigator; Protocols documentation; Publications; Research; Research Infrastructure; Resources; Risk; Rodent; Self Administration; Source; Staging; Testing; Time; Tissue Banking; Tissue Banks; Tissues; United States National Institutes of Health; alcohol exposure; alcohol research; animal tissue; base; brain behavior; cost; drinking; forest; longitudinal design; nonhuman primate; novel; tool; vervet

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Excessive alcohol ingestion, occasionally or chronically, is co-morbid with medical disorders affecting the brain and behavior as well as other organ damage. Much of what is known about risk for and the consequence of heavy alcohol consumption, including mechanisms of organ damage, is derived from rodent studies or retrospective human accounts. The Monkey Alcohol Tissue Research Resource (MATRR) is a unique post-mortem tissue bank to ensure tissue from animals chronically drinking alcohol, as well as their related drinking and genetic information, is available to the wider alcohol research community insuring reduced numbers of animals used in research. The tissue is derived from a standard protocol of ethanol self-administration in three species of monkeys housed at ONPRC (rhesus and cynomolgus) and Wake Forest (vervet). This resource will provide novel data for hypothesis testing relating the risk for and consequences of alcohol consumption and serve to bi-directionally bridge the gap between rodent and human studies. The basis of the MATRR is that non human primates, specifically monkeys, show a range of drinking excessive amounts of alcohol (3.0 g/kg or a 12 drink equivalent/day) over long periods of time (12-30 months) with concomitant pathological changes in endocrine, hepatic and central nervous system (CNS) processes. These longitudinal designs span "stages of drinking" from ethanol-naive to early alcohol exposure to chronic abuse. The demand for, and the quality of, the tissues are already high as reflected in the number of requests and publications. Nevertheless, this resource needs further development in order to fulfill its potential as a cutting edge translational tool in alcoholism research.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 过量的酒精摄入偶尔或长期摄入，与影响大脑和行为以及其他器官损害的医学疾病并发症。关于风险和大量饮酒的后果，包括器官损害的机制，大部分已知的风险和后果来自啮齿动物研究或回顾性人类帐户。猴子酒精组织研究资源（MATRR）是一种独特的验尸组织库，可确保动物长期饮用酒精的组织及其相关的饮酒和遗传信息，可为更广泛的酒精研究社区提供，以确保减少研究中使用的动物数量。 该组织源自乙醇自我给药的标准方案，该方案是在ONPRC（恒河猴和cynomolgus）和Wake Forest（Vervet）的三种猴子中。该资源将为假设检验提供新的数据，该假说检验将饮酒的风险和后果与饮酒的风险和后果相关，并在汇总啮齿动物和人类研究之间的差距上弥合差距。 MATRR的基础是，非人类灵长类动物（特别是猴子）在长时间（12-30个月）内表现出一系列饮酒过量的酒精（3.0 g/kg或12饮料同等/天），内分泌，肝和中枢神经系统（CNS）的病理学变化。这些纵向设计涵盖了“饮酒阶段”，从乙醇 - 早期酒精暴露于慢性虐待。对请求和出版物的数量反映，对组织的需求和质量已经很高。然而，该资源需要进一步的发展，以实现其作为酒精中毒研究中最先进的转化工具的潜力。