CELLULAR IMMUNE RESPONSES IN NATURALLY SIV-INFECTED SOOTY MANGABEYS

自然感染 SIV 的乌白白眉猴的细胞免疫反应

• 批准号: 7562377
• 负责人: CRISTIAN APETREI
• 金额: $ 7.16万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562377
• 关键词: Acquired Immunodeficiency Syndrome; African; CD4 Positive T Lymphocytes; Cell Count; Cercocebus; Cercocebus atys; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Disease Progression; Employee Strikes; Evolution; Funding; Grant; HIV; Human; Immune; Immune response; Infection; Institution; Investigation; Monkeys; Research; Research Personnel; Resources; SIV; Source; T-Lymphocyte; United States National Institutes of Health; Viral Load result; Virus; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In striking contrast to Human Immunodeficiency Virus (HIV)--infected humans, natural hosts of Simian Immunodeficiency Virus do not progress to AIDS despite many years of infection. The mechanisms underlying the absence of disease progression in naturally SIV-infected monkeys are largely unknown, but their investigation will likely provide clues to the pathogenic mechanisms of HIV, which in fact originated from cross-species transmissions of SIVs.. Here we show that in SIV-infected sooty mangabeys, an African natural host species, the absence of AIDS is not related to the presence of strong and broadly reactive cellular immune responses to the virus. In fact, while SIV-specific T cells are promptly detectable in the majority of SIV-infected mangabeys, their magnitude and breadth are markedly lower than in HIV infected humans and do not correlate with either viral load or CD4+ T-cell counts. These data indicate that mechanisms other than a strong immune control underlie the disease-free co-evolution of SIV and its natural hosts.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 与人类免疫缺陷病毒（HIV）形成鲜明对比的是感染人类，尽管有多年的感染，但自然的猿猴免疫缺陷病毒的天然宿主仍未发展为艾滋病。自然感染的猴子中缺乏疾病进展的机制在很大程度上是未知的，但是他们的研究可能会为艾滋病毒的致病机制提供线索，实际上，这实际上是sivs的跨物种传播。在这里，我们在这里表明，在SIV感染的烟草自然界中，非洲自然人的存在，是非洲自然界的不适，是非洲自然界的不存在的，是非洲自然界的不适，是sivs sivs的跨性别，是sivs的，是sivs sivs的疾病。细胞免疫反应对病毒。实际上，尽管在大多数SIV感染的芒果中可以立即检测到SIV特异性T细胞，但它们的大小和广度明显低于HIV感染的人，并且与病毒载荷或CD4+ T细胞计数不相关。这些数据表明，强大免疫控制以外的机制是SIV及其自然宿主的无疾病共同进化的基础。