CORE--PHYSIOLOGY

核心--生理学

• 批准号: 7392814
• 负责人: ELEFTHERIA MARATOS-FLIER
• 金额: $ 12.45万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392814
• 关键词: Affect; Animals; Area; Awareness; Body Composition; Boston; Carbon Dioxide; Cities; Complex; DEXA; Data; Data Analyses; Desire for food; Endocrine; Energy Metabolism; Evaluation; Experimental Designs; Food; Funding; Graph; Heating; Homeostasis; Human; Instruction; Intake; Laboratory Animals; Lead; Life; Measures; Metabolic; Monitor; Mus; Neuropeptides; Obese Mice; Obesity; Oxygen Consumption; Peptides; Peripheral; Physiology; Production; Regulation; Research Personnel; Rodent; Rodent Model; Rough endoplasmic reticulum; Running; Services; System; Technology; Time; Water; design; drinking; feeding; insight; instrument; instrumentation; interest; mouse model; research study; respiratory; tool

Evaluation of energy expenditure has become an indispensable tool for studies involving lean and obese mice. Systems capable of such evaluation are commercially available and can monitor activity, oxygen consumption, CO2 production, feeding and drinking. From this data respiratory quotient, RER and heat produced can be calculated. However the systems are expensive and sophisticated. The Endocrine Division at BIDMC has a sixteen animal monitoring system purchased by outside funds. To make the technology available to PPG investigators, monitoring is offered as a core service. Following monitoring data is provided to the requesting investigator as Excel spreadsheets and graphs plotting the variable of interest in real time. The core assists in experimental design and data analysis. An additional service of the core is assistance with DEXA monitoring for PPG projects.

能量消耗的评估已成为瘦小鼠和肥胖小鼠研究中不可或缺的工具。能够进行此类评估的系统在商业上是可用的，并且可以监控 活动、耗氧量、二氧化碳产生、摄食和饮水。从这个数据呼吸 可以计算商、RER 和产生的热量。然而，这些系统价格昂贵且 复杂的。 BIDMC 内分泌部门拥有由外部资金购买的 16 套动物监测系统。为了向 PPG 调查人员提供该技术，监控作为核心服务提供。以下监测数据以 Excel 电子表格和实时绘制感兴趣变量的图表的形式提供给提出请求的研究者。核心协助实验设计和数据分析。核心的一项附加服务是协助 PPG 项目进行 DEXA 监测。