Echo MRI 3-in-1

回波 MRI 三合一

• 批准号: 7221653
• 负责人: ELEFTHERIA MARATOS-FLIER
• 金额: $ 11万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221653
• 关键词: Biopsy Specimen; Body Composition; Bypass; Endocrine; Endocrinology; Equipment; Faculty; Health; Human; Human Development; Magnetic Resonance Imaging; Molecular; Obesity; Overweight; Pathway interactions; Population; Prevalence; Research Personnel; Rodent; Services; Technology; Tissue Sample; cohort; insight; mouse model; size

DESCRIPTION (provided by applicant): Echo MRI-100(tm) 3-in-1 Obesity is a problem with increasing impact on human health and at present more than 60% of the population in the U.S. is either frankly obese or overweight. Despite the prevalence of this problem there are few effective treatments. Mouse models have provided valuable insights into understanding pathways important in the development of human obesity. This includes understanding both molecular pathways and the effects of dietary induced obesity. Analysis of mouse models requires technical capacity to evaluate body composition, particularly adiposity. The technology currently available to the group of obesity researchers at the BIDMC division of Endocrinology has significant limitations. Acquisition of the requested EchoMRI 3-in-1 will bypass this limitation and enhance ability to perform studies and also decrease the size of cohorts required. In addition this equipment will provide a heretofore unavailable capacity to evaluate composition of tissue samples, either from rodents or from human biopsy samples. Because of the capacity of the equipment, in addition to projected significant use by BIDMC Endocrine faculty and their collaborators the service can be offered to other BIDMC investigators.

描述（由申请人提供）：Echo MRI-100(tm) 三合一 肥胖是一个对人类健康影响越来越大的问题，目前美国超过 60% 的人口明显肥胖或超重。尽管这个问题普遍存在，但有效的治疗方法却很少。小鼠模型为了解人类肥胖发展的重要途径提供了宝贵的见解。这包括了解分子途径和饮食引起的肥胖的影响。小鼠模型的分析需要评估身体成分的技术能力，特别是肥胖程度。 BIDMC 内分泌科肥胖研究小组目前可用的技术有很大的局限性。获得所需的 EchoMRI 三合一将绕过这一限制，增强进行研究的能力，并减少所需的队列规模。此外，该设备将提供迄今为止无法评估来自啮齿动物或来自人类活检样本的组织样本的成分的能力。由于设备的容量，除了预计 BIDMC 内分泌教员及其合作者的大量使用外，还可以向其他 BIDMC 研究人员提供该服务。