Exploring otoacoustic emissions with intracochlear pressure measurements

通过耳蜗内压力测量探索耳声发射

• 批准号: 7433735
• 负责人: Wei Dong
• 金额: $ 8.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433735
• 关键词: Auditory; Basilar Membrane; Categories; Cells; Characteristics; Clinic; Clinical Research; Cochlea; Diagnosis; Ear; Evaluation; External auditory canal; Frequencies; Generations; Gerbils; Hearing; Infant; Labyrinth; Lead; Light; Link; Liquid substance; Location; Measurement; Measures; Mechanics; Motion; Non-linear Models; Numbers; Patients; Personal Satisfaction; Phase; Positioning Attribute; Principal Investigator; Process; Protocols documentation; Range; Relative (related person); Research; Role; Scala Tympani; Series; Source; Stapes; Stimulus; Structure; System; Techniques; Testing; Title; Travel; Variant; Work; base; hearing impairment; human SLC25A5 protein; improved; in vivo; middle ear; otoacoustic emission; pressure; programs; research study; response; sensor; sound; theories; transmission process

DESCRIPTION (provided by applicant): This application aims to further investigate the important issue of how sound energy travels out of the cochlea and to provide a bridge between cochlear mechanics and otoacoustic emissions. In addition to perceiving sound, the ear also makes sound, as a result of the cell-based cochlear nonlinearity. Exactly how this energy radiates from the inner ear has been a major unresolved question since the discovery of these so-called "otoacoustic emissions" in 1976. This application will use the unique and powerful micro-pressure-sensor to probe the cochlear mechanics and a sensitive microphone system as the receiver to calibrate sound and measure the sound pressure in the ear canal. Direct and simultaneous measurements of the intracochlear pressure and ear canal pressures to sound stimuli will be performed in gerbil normal ears in vivo. Cochlear distortion products (DPs) will be used as the ideal intracochlear sound sources of the distortion product otoacoustic emissions (DPOAEs) being detected in the ear canal. The intracochlear approach will be at the basal turn of cochlea, where the cochlear mechanism has been well established in the field and also in the lab. By directly comparing the DPOAEs and DPs, the sound transmission in reverse direction will be further explored with the specific aims to category the role of the reverse traveling wave and the cochlear fluid, the cochlear nonlinearity and the contributions of DPs 'generator' & 'reflector' components to DPOAEs. The measurements will significantly improve our understanding of how the cochlea is excited by and produces sound and how the sound travels out of the cochlea. These sound emissions from the ear are widely used in clinic to detect and diagnose forms of hearing impairment, especially in infants and other patients whose hearing cannot be tested in other ways. Understanding the mechanisms of their generation and transmission is therefore crucial in many clinical and research applications. How exactly sound energy radiates from the inner ear has been a major unresolved question since the discovery of otoacoustic emissions (OAEs) in 1978 by Kemp. In addition to perceiving sound, the cochlea also generates sound, as a result of nonlinear cell-based forces. These 'cochlea-generated' sounds, known as OAEs being detected in the ear canal, are a noninvasive probe used in the clinic to detect and diagnose hearing impairment. Understanding the mechanisms of their generation and transmission is therefore crucial to many clinical and research applications. Recently a simultaneous recording technique of intracochlear pressure and EC pressure in gerbils has been well established in the lab, which has proven to be very illuminating for understanding cochlear mechanics. This proposal aims to use this combined studies of OAEs and intracochlear pressure to probe important aspects of the emission process in normal gerbil cochlea in vivo. The results of this project will lead to further understanding on the specific questions of (1) the intracochlear path OAEs take and (2) the possibility for amplification as these sounds travel out of the cochlea, and (3) the presence of different OAE components.

描述（由申请人提供）：本申请旨在进一步研究声音能量如何从耳蜗传播并提供耳蜗机械和耳声发射之间的桥梁的重要问题。除了感知声音外，由于基于细胞的人工耳蜗非线性，耳朵还可以使声音发出声音。自从1976年发现这些所谓的“耳声排放”以来，这种能量如何从内耳散发出一个主要的尚未解决的问题。此应用程序将使用独特而强大的微压传感器来探测耳蜗机制和敏感的微型型系统作为接收器的敏感性微音机制，以校准声音和测量耳机中的声音压力。直接和同时测量的2刺激性压力和耳道压力将在体内在Gerbil正常耳朵中进行声音刺激。耳蜗失真产物（DPS）将用作在耳道中检测到的失真产物耳声排放（DPOAE）的理想的变形产物。当水上方法将是在耳蜗的基本转弯处，那里的人工耳蜗机制已在现场和实验室中得到了很好的确定。通过直接比较DPOAE和DPS，将进一步探索沿相反方向的声传感器，以对反向行动波和耳蜗流体的作用，人工耳蜗非线性以及DPS“发电机”和“反射器”组件对DPOAE的作用进行分类。这些测量值将显着提高我们对耳蜗如何受到激发并产生声音以及声音如何从耳蜗传播的理解。这些来自耳朵的声音排放量被广泛用于诊所，以检测和诊断听力障碍形式，尤其是在婴儿和其他无法以其他方式测试的婴儿和其他患者中。因此，在许多临床和研究应用中，了解其产生和传播的机制至关重要。 自1978年肯普（Kemp）在1978年发现耳声发射（OAE）以来，声音能量如何从内耳散发出来一直是一个尚未解决的问题。除了感知声音之外，由于非线性细胞的力，耳蜗还产生声音。这些“耳蜗生成的”声音，被耳道中检测到的OAE，是诊所中用于检测和诊断听力障碍的无创探针。因此，了解其产生和传播的机制对于许多临床和研究应用至关重要。最近，在实验室中已经建立了一项同时的循环技术记录技术和eC压力的技术，事实证明，该技术非常有启发性地了解人工耳蜗。该提案旨在利用OAE的综合研究和当经压力的结合研究，以探测正常的沙鼠耳蜗体内发射过程的重要方面。 该项目的结果将进一步了解（1）OAES所采用的（2）随着这些声音从耳蜗传播时，以及（3）存在不同OAE组件时的扩增的可能性。