Exploring otoacoustic emissions with intracochlear pressure and motion measuremen

通过耳蜗内压力和运动测量探索耳声发射

• 批准号: 8292346
• 负责人: Wei Dong
• 金额: $ 24万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8292346
• 关键词: Amplifiers; Auditory; Back; Basilar Membrane; Cells; Characteristics; Clinic; Cochlea; Diagnostic; External auditory canal; Foundations; Frequencies; Generations; Gerbils; Goals; Hearing; Human; Image; Impairment; Laboratories; Lasers; Lead; Light; Link; Liquid substance; Maps; Measurement; Measures; Mechanics; Modeling; Motion; Outer Hair Cells; Physiology; Principal Investigator; Process; Research; Rest; Rodent; Role; Scala Tympani; Sensory; Shapes; Signal Transduction; Site; Source; Stapes; Techniques; Testing; Travel; Work; base; clinical application; computerized data processing; design; hearing screening; in vivo; middle ear; operation; otoacoustic emission; pressure; programs; research study; response; sensor; sound; theories; tool; transmission process

DESCRIPTION (provided by applicant): The experiments proposed in the current application use well-established micro-pressure-sensor and laser Doppler vibrometer techniques to probe underlying cochlear mechanics relating to otoacoustic emissions (OAEs). This application aims to provide direct intracochlear observation in vivo to further understand the fundamental questions in OAE generation, propagation and cochlear signal processing in reverse transmission. The first aim will explore the cochlear active process in reverse transmission and the rest of the aims will continue and extend our previous work on the generation and propagation of distortion product OAEs (DPOAEs) in the cochlea. OAEs are sounds generated within the cochlea and being detected in the ear canal, carrying the information about the mechanisms that generate and shape them, thus providing a noninvasive view into cochlear mechanics. However, how to relate OAE to cochlea mechanics is a big challenge in OAE research. In the forward direction, sound causes a traveling wave along the cochlear partition, which is boosted by the outer hair cells' activity (cochlear amplifier). However, the role of cochlear amplifier and cochlear fluid in cochlear reverse transmission is not clear. With simultaneous intracochlear (the basilar membrane velocity and intracochlear pressure) and ear canal pressure measurements, aim one studies the generation sites of OAE in the cochlea and further explore multiple tones suppression in active cochleae; aim two is designed to quantify the traveling wave and compression wave pressures in both forward and reverse transmissions; aim three explores the cochlear active process in reverse transmission. Thus the results will provide fundamental intracochlear observations, test the OAE generation theories and form the foundation for developing three-dimensional cochlear model. Finally, results from the current application will lead to more efficient OAE hearing screening program used in research and clinic. PUBLIC HEALTH RELEVANCE: Otoacoustic emissions (OAEs) have been used in research and the clinic as a noninvasive tool to probe cochlear mechanics. However, how to link the OAE to specific cochlear mechanics is still not clear. The current application uses intracochlear approaches, micro-pressure-sensor and laser interferometer techniques, to bridge OAEs to cochlear physiology. The study will provide valuable intracochlear evidence on cochlear signal processing in OAE generation and transmission, test OAE theories and lead to more effective hearing screening programs for research and clinical applications.

描述（由申请人提供）：当前申请中提出的实验使用良好的微压传感器和激光多普勒振动仪技术来探测与耳声发射有关的基础耳蜗机制（OAES）。该应用程序旨在在体内直接提供直接的体内观察，以进一步了解OAE产生，传播和耳蜗信号处理的基本问题。第一个目的将探索反向传播中的人工耳蜗积极过程，其余目标将继续并扩展我们先前关于在耳蜗中失真产物OAE（DPOAES）的生成和传播的工作。 OAE是在耳蜗中产生的声音，并在耳道中被检测到，并带有有关生成和塑造它们的机制的信息，从而将无创的视图提供给了耳蜗机械师。但是，如何将OAE与耳蜗力学联系起来是OAE研究的巨大挑战。在向前的方向上，声音会导致沿着人工耳蜗的行动波，这是由于外毛细胞的活性（耳蜗放大器）所增强的。然而，人工耳蜗放大器和人工耳蜗在耳蜗反向传播中的作用尚不清楚。鉴于同时进行的（基底膜速度和2​​）和耳道压力测量值，目标是研究耳蜗中OAE的产生位点，并进一步探索活性耳蜗中的多种音调。 AIM二的设计旨在量化前进和反向传输中的行驶波和压缩波压力； AIM 3探索了反向传输中的人工耳蜗主动过程。因此，结果将提供基本的运动内观测，测试OAE的产生理论，并为开发三维耳蜗模型构成基础。最后，当前应用的结果将导致研究和诊所中使用的更有效的OAE听力筛选计划。 公共卫生相关性：耳声排放（OAE）已在研究和诊所中用作探测耳蜗机械的无创工具。但是，如何将OAE连接到特定的人工耳蜗机械师仍然不清楚。当前的应用程序采用了当前的方法，微压传感器和激光干涉仪技术，将OAE桥接到人工耳蜗生理学上。该研究将提供有关OAE产生和传输，测试OAE理论的人工耳蜗信号处理的有价值的方向证据，并为研究和临床应用提供更有效的听力筛查计划。