RADIOLABELING/DOSIMETRY

放射性标记/剂量测定

基本信息

批准号：
7414802
负责人：
PETER D. EMANUEL
金额：
$ 17.39万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2010-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The Radiolabeling/Imaging/Dosimetry Shared Facility was established in 1994 as the Radiolabeling Shared Facility in order to provide radiolabeling services for in vitro laboratory studies, in vivo animal model investigations and in vivo human clinical protocols. The facility has extensive experience with radiolabeling procedures for a wide range of radioactive isotopes and provides appropriate quality control procedures to assure standardized and high quality reagents to Cancer Center members. The facility generates radiolabeled reagents for "human use" including safety-oriented procedures for large doses of therapeutic radioactive investigational agents. The expansion of the facilities capabilities, including the purchase of an AXIS (Picker International/Marconi) dual-head camera imaging system in 2001, provides high quality imaging and dosimetry estimate analysis for the protocols in our immunotherapy program. The development of these additional capabilities has allowed the facility to play an important role in our translational research and targeted immunotherapy efforts. The facility provides consultation services related to radiolabeling of proteins, peptides and oligonucleotides to CCC members, hi addition, the facility provides a centralized purchasing of isotopes, which leads to a very cost-effective utilization of research funds for CCC members. The facility has responsibility for radiation waste management in the Wallace Tumor Institute including acquisition, utilization and documentation of waste generation and disposal. The facility provides documentation of all radiolabeled reagents for human use according to FDA, state and other regulatory agencies. The Radiolabeling/Imaging/Dosimetry Shared Facility is the Cancer Center's interface with the Radiation Safety Department and Waste Management group of UAB.

描述（由申请人提供）：放射标记/成像/剂量法共享设施是成立于1994年，是放射标记的共享设施，以便为体外实验室研究，体内动物模型研究和体内人类临床方案提供放射标记服务。该设施具有广泛的放射性放射性同位素的放射性标记程序的丰富经验，并提供了适当的质量控制程序，以确保为癌症中心成员确保标准化和高质量试剂。该设施生成用于“人使用”的放射标签试剂，包括针对大剂量的放射性研究剂的面向安全性程序。设施功能的扩展，包括在2001年购买轴（Picker International/Marconi）双头相机成像系统，为我们的免疫疗法计划中的协议提供了高质量的成像和剂量计估计分析。这些额外功能的发展使该设施能够在我们的翻译研究中发挥重要作用，并针对免疫疗法工作。该设施提供了与CCC成员的蛋白质，肽和寡核苷酸的放射性标记有关的咨询服务，HI，该设施提供了集中的购买同位素，这导致CCC成员的研究基金非常有效地利用。该设施负责华莱士肿瘤研究所的辐射废物管理，包括收购，利用和记录废物产生和处置。该设施提供了根据FDA，州和其他监管机构根据人类使用的所有放射性标记试剂的文档。放射标记/成像/剂量学共享设施是癌症中心与UAB辐射安全部和废物管理小组的界面。