2008 Barriers of the CNS Gordon Research Conference

2008 CNS 戈登研究会议的障碍

• 批准号: 7476625
• 负责人: THOMAS Paul DAVIS
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476625
• 关键词: Address; Alzheimer' s Disease; Area; Basic Science; Blood; Blood - brain barrier anatomy; Brain; Central Nervous System Diseases; Clinical; Communities; Disease; Future; Goals; Health; Image; Inflammation; International; Knowledge; Maps; Neuraxis; New Hampshire; Numbers; Participant; Patients; Pharmaceutical Preparations; Play; Public Health; Regulation; Request for Proposals; Research; Research Personnel; Retinal; Role; Schools; Spinal Neoplasms; Stroke; Structure of choroid plexus; Therapeutic; Tight Junctions; Work; day; neurovascular unit; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting to be held on Barriers of the Central Nervous System (CNS) in Tilton, New Hampshire on June 22 to 27, 2008. The broad and long term goal of this conference is to increase our understanding of the fundamental mechanisms associated with the blood brain barrier (BBB)/neurovascular unit (NVU) in health and disease. One of the primary goals of this meeting is to understand why the BBB excludes important therapeutics from entering the brain of people afflicted with diseases of the CNS. The issue of CNS disease states and the role the BBB/NVU plays in these disease states is the central theme of our meeting. The Gordon Research Conference (GRC) on Barriers of the CNS is unique because it brings together (equally) both clinical and basic science researches in a format where full and honest exchange occurs on subjects important to the patient. It is to our mutual benefit that we work together to solve the long term problem associated with an inability to treat CNS disease states because of our paucity of knowledge about the BBB/NVU. The Specific Aims of this meeting will be to convene 45 speakers that present critical areas of both basic and clinical disease research with a total of 150 participants for a five day conference in the isolated and private setting of Tilton School, Tilton, New Hampshire. The program will have two keynote addresses and eight sessions that broadly address current issues in BBB Tight Junctions and Barrier Regulation, BBB Transporters and Barrier Functions, Choroid plexus/Blood-CSF Barrier in health and disease, BBB/NVU imaging, retinal-, spinal-, and tumor barriers, BBB/NVU in stroke, BBB/NVU in Alzheimer's disease, and the BBB/NVU in inflammation. The significance of this application is that the GRC on Barriers of the CNS is one half of the total number of conferences offered in the area of Barriers of the CNS. Only one other conference is offered and it is offered in alternate years to the GRC. This GRC is our only conference every two years. This GRC conference propels research in the international community of BBB/NVU researchers. The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date.

描述（由申请人提供）：本提案请求部分支持将于 2008 年 6 月 22 日至 27 日在新罕布什尔州蒂尔顿举行的关于中枢神经系统 (CNS) 障碍的国际会议。本提案的广泛和长期目标会议的目的是增加我们对健康和疾病中血脑屏障（BBB）/神经血管单元（NVU）相关基本机制的理解。这次会议的主要目标之一是了解为什么 BBB 排除重要的治疗药物进入患有中枢神经系统疾病的人的大脑。 CNS 疾病状态问题以及 BBB/NVU 在这些疾病状态中发挥的作用是我们会议的中心主题。关于中枢神经系统障碍的戈登研究会议 (GRC) 是独一无二的，因为它以一种形式（同等地）汇集了临床和基础科学研究，就对患者重要的主题进行充分和诚实的交流。由于我们对 BBB/NVU 的了解匮乏，我们共同努力解决与无法治疗 CNS 疾病状态相关的长期问题，这符合我们的共同利益。本次会议的具体目标是召集 45 名发言人，介绍基础和临床疾病研究的关键领域，共有 150 名与会者，在新罕布什尔州蒂尔顿的蒂尔顿学校的孤立和私人环境中举行为期五天的会议。该计划将有两个主题演讲和八个会议，广泛讨论 BBB 紧密连接和屏障调节、BBB 转运蛋白和屏障功能、健康和疾病中的脉络丛/血液-脑脊液屏障、BBB/NVU 成像、视网膜、脊髓等方面的当前问题。 - 以及肿瘤屏障、中风中的 BBB/NVU、阿尔茨海默病中的 BBB/NVU 以及炎症中的 BBB/NVU。该申请的意义在于，CNS 障碍 GRC 占 CNS 障碍领域提供的会议总数的一半。仅提供一次其他会议，并且每隔一年向 GRC 提供一次。这次 GRC 是我们唯一每两年一次的会议。这次 GRC 会议推动了国际 BBB/NVU 研究人员社区的研究。该应用程序与健康的相关性是显而易见的。讨论将确定用药物治疗中枢神经系统疾病的策略。 GRC 的讨论将规划未来如何理解 CNS 疾病状态和 BBB/NVU，并讨论为什么许多 CNS 疗法迄今为止不成功。公共健康相关性：此应用程序的健康相关性是明确的。讨论将确定用药物治疗中枢神经系统疾病的策略。 GRC 的讨论将规划未来如何理解 CNS 疾病状态和 BBB/NVU，并讨论为什么许多 CNS 疗法迄今为止不成功。