LONGITUDINAL STUDIES OF AD AND SIVD

AD 和 SIVD 的纵向研究

• 批准号: 7458885
• 负责人: DAN M. MUNGAS
• 金额: $ 32.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7458885
• 关键词: Accounting; Address; Affect; Alzheimer' s Disease; Brain; Cerebrovascular Disorders; Cognition; Cognitive; Data; Dementia; Diagnosis; Disease Marker; Elderly; Enrollment; Evaluation; Hippocampus (Brain); Impaired cognition; Impairment; Lesion; MRI Scans; Magnetic Resonance Imaging; Measures; Memory; Methods; Pathology; Patients; Program Research Project Grants; Purpose; Rate; Source; Testing; cerebral atrophy; design; executive function; follow-up; functional decline; functional disability; gray matter; hippocampal atrophy; neuroimaging; neuropathology; neuropsychological; white matter

The purpose of this project is to better characterize independent and interactive contributions to dementia of AD and sCVD. This project will use common, core data that is available for all subjects enrolled in the overall program project grant (PPG). It will focus on global and specific cognitive abilities and independent functioning as dependent variables and will incorporate date from longitudinal follow-up and neuropathology to address questions about additive and interactive effects of AD and sCVD in determining presentation and progression of dementia. Mechanisms of cognitive and functional change in AD and sCVD will be examined using cross sectional, longitudinal, and pathological data. Multiple replications wilt be accomplished by performing the same analyses using data from these three sources so that convergence of timings can be directly compared. The availability of data from neuropathology will allow for a critical form of replication. Hypotheses to be tested in this project are: 1) Cognitive and functional impairment in sCVD and AD are primarily due to loss of volume of cortical gray matter and hippocampus, 1a) Memory is primarily related to hippocampal volume and executive function to frontal cortical gray matter volume, 1b) Predicted relationships from Hypothesis 1 will be supported in neuropathology diagnosed cases without AD and independently in pathology diagnosed cases with AD, 2) sCVD and AD neuropathology measures and MRI markers of these pathologies will make additive and independent contributions to cognitive impairment and dementia, and 3) Progression to dementia in non-demented cases at initial evaluation will be strongly predicted by MRI markers of AD pathology and weakly predicted by markers of sCVD pathology.

该项目的目的是更好地表征对AD和SCVD痴呆症的独立和互动贡献。该项目将使用通用的核心数据，可用于全面计划项目赠款（PPG）的所有受试者。它将集中在全球和特定的认知能力以及独立功能上作为因变量，并将纵向随访和神经病理学的日期纳入有关AD和SCVD在确定痴呆症的表现和进展方面的添加和交互作用的问题。将使用横截面，纵向和病理数据检查AD和SCVD的认知和功能变化的机制。多次复制可以通过 使用来自这三个来源的数据进行相同的分析，以便可以直接比较时间收敛。来自神经病理学的数据的可用性将允许复制的关键形式。 Hypotheses to be tested in this project are: 1) Cognitive and functional impairment in sCVD and AD are primarily due to loss of volume of cortical gray matter and hippocampus, 1a) Memory is primarily related to hippocampal volume and executive function to frontal cortical gray matter volume, 1b) Predicted relationships from Hypothesis 1 will be supported in neuropathology diagnosed cases without AD and independently in pathology diagnosed cases with AD, 2）这些病理的SCVD和AD神经病理学措施和MRI标记将对认知障碍和独立贡献以及 痴呆症和3）在初始评估时在非痴呆病例中向痴呆症的进展将通过AD病理学的MRI标记来强烈预测，而SCVD病理学的标记却弱预测。