Predicting Response to Memory Training in TBI with fMRI

使用 fMRI 预测 TBI 记忆训练的反应

• 批准号: 7417967
• 负责人: CARY R SAVAGE
• 金额: $ 18.01万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7417967
• 关键词: Address; Adult; Affect; Behavior; Bilateral; Biological Neural Networks; Brain; Brain region; Chronic; Clinical; Cognitive; Condition; Control Groups; Cues; Data; Development; Exploratory/Developmental Grant; Functional Magnetic Resonance Imaging; Handedness; Impaired cognition; Impairment; Individual; Individual Differences; Injury; Lead; Learning; Left; Magnetic Resonance Imaging; Measures; Memory; Methods; Outcome; Participant; Patients; Pattern; Performance; Prefrontal Cortex; Process; Recovery; Semantics; Severities; Social Impacts; Staging; Standards of Weights and Measures; Support System; Testing; Training; Traumatic Brain Injury; Verbal Learning; Work; behavior measurement; cognitive function; disability; executive function; functional outcomes; improved; in vivo; indexing; innovation; interest; neuroimaging; neuromechanism; relating to nervous system; response

DESCRIPTION (provided by applicant): This is the second revised application for an R21 entitled: Predicting Response to Memory Training in TBI with fMRI. Traumatic brain injury (TBI) is a leading cause of disability in young otherwise healthy adults. The consequences of TBI are highly variable, with some individuals showing good recovery and others suffering chronic disability with profound cognitive and social impacts. Long-term outcome from TBI is difficult to predict using standard measures of injury severity, cognitive impairment, and conventional neuroimaging. Cognitive activation studies using fMRI may offer improved methods for outcome prediction in TBI. fMRI paradigms enable quantification of neural network function during cognitive challenges, providing in vivo measures of functional integrity. We predict that these data will be useful in quantifying the degree of functional neural impairment, understanding neural mechanisms underlying cognitive impairment in individuals with TBI, and ultimately predicting long-term outcome. This project aims to identify mechanisms of recovery from TBI by examining brain systems supporting the use of semantic strategies during non-cued and cued verbal learning using functional magnetic resonance imaging (fMRI). The study addresses two Specific Aims: 1. Assess the ability of TBI patients and matched healthy control (HC) participants to utilize semantic strategies under both non-cued and cued conditions and define how patterns of brain activation change to support this process. 2. Examine specific patterns of brain activation with fMRI in predefined regions of interest (ROI) in TBI and HC groups and determine how individual differences in brain activation relate to cognitive functioning and behavior in natural settings. This work is innovative and at an early stage of development, and thus appropriate for the R21 mechanism.

描述（由申请人提供）：这是R21的第二个修订申请，标题为“：预测使用fMRI中对TBI的内存训练的响应”。创伤性脑损伤（TBI）是年轻健康成年人残疾的主要原因。 TBI的后果是高度可变的，有些人表现出良好的康复，而另一些人则具有深远的认知和社会影响。使用损伤严重程度，认知障碍和常规神经影像的标准措施，很难预测TBI的长期结局。使用fMRI的认知激活研究可能会提供改进的TBI预测方法。 FMRI范式可以在认知挑战期间对神经网络功能进行量化，从而提供了功能完整性的体内度量。我们预测，这些数据将有助于量化功能神经障碍的程度，了解TBI患者认知障碍的神经机制，并最终预测长期结果。该项目旨在通过检查使用功能磁共振成像（fMRI）期间使用语义策略的大脑系统（fMRI）来确定从TBI恢复的机制。该研究涉及两个具体目的：1。评估TBI患者并匹配健康对照（HC）参与者在非辅助和提示条件下使用语义策略的能力，并定义大脑激活模式如何改变以支持这一过程。 2。在TBI和HC组的预定义区域（ROI）中使用fMRI的大脑激活的特定模式，并确定脑激活中个体差异与自然环境中的认知功能和行为如何相关。这项工作是创新的，并且在发展的早期阶段，因此适合R21机制。

项目成果

Effectiveness of Semantic Encoding Strategy Training after Traumatic Brain Injury is Correlated with Frontal Brain Activation Change.

创伤性脑损伤后语义编码策略训练的有效性与额叶脑激活变化相关。

• DOI: 10.4172/2329-9096.1000254
• 发表时间: 2015
• 期刊: International journal of physical medicine & rehabilitation
• 作者: Lepping,RebeccaJ;Brooks,WilliamM;Kirchhoff,BrendaA;Martin,LauraE;Kurylo,Monica;Ladesich,Linda;Lierman,JoAnn;Varghese,George;Savage,CaryR
• 通讯作者: Savage,CaryR