PET AND FUNCTIONAL MRI STUDIES OF MEMORY LOSS WITH AGING

衰老过程中记忆丧失的 PET 和功能 MRI 研究

• 批准号: 2889826
• 负责人: CARY R SAVAGE
• 金额: $ 13.64万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889826
• 关键词: age difference; aging; animal developmental psychology; behavioral /social science research tag; brain metabolism; functional magnetic resonance imaging; human old age (65+); human subject; learning; mathematical model; memory disorders; neurophysiology; positron emission tomography

The Candidate's primary interest is in the study of brain mechanisms underling mental states, particularly in relation to changes in memory function that occur during the course of aging. Many mental health disorders of aging are characterized by abnormal memory decline. Thus, the proposed research should have important implications concerning the pathophysiology of clinical disorders of aging. The Candidate's previous training in clinical psychology, event-related potentials (ERP), and neuropsychology led to his current interest in memory changes with aging and methods of evaluating these changes with neuroimaging. Functional neuroimaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), provide powerful tools with which to examine regional brain activity during cognitive tasks. In addition, new statistical methods have become available, such as linear structural relations modeling (LISREL) which can be used to test models describing the relationship between brain function cognitive performance. The research project designed to complement this training program involves the development and application of functional neuroimaging activation techniques to examine neural systems mediating memory in young and elderly adults. Specifically, the Candidate proposes to study implicit skill learning in young and elderly subjects. Previous cognitive research indicates that explicit memory is consistently impaired with aging, while changes in implicit memory depend on the specific function examined. For instance, studies of implicit memory suggest that skill learning may decline in older adults, while other types of implicit memory, such as repetition priming are preserved. The initial phase of the research project will include paradigm development off-line in both young and old subjects, and subsequent application as an activation technique for PET in young (30-39) and elderly (70-79) adults. Later phases of the research project will involve the evaluation of skill learning in similar subjects with fMRI. In addition some of the subjects will receive both PET and fMRI during this phase of the project in order to provide data for direct comparisons of the two technologies. LISREL analyses will be used to test models of brain function, including changes in function related to aging.

候选人的主要兴趣是研究大脑机制 基础心理状态，特别是与记忆变化有关 衰老过程中发生的功能。许多心理健康 衰老的疾病的特征是记忆力异常下降。因此， 拟议的研究应具有关于 衰老的临床疾病的病理生理学。候选人的先前 临床心理学，与事件相关潜力（ERP）和 神经心理学导致他目前对记忆变化的兴趣随着衰老而变化 以及通过神经成像评估这些变化的方法。功能 神经影像学技术，例如正电子发射断层扫描（PET）和 功能磁共振成像（fMRI），提供强大的工具 在认知任务中检查区域大脑活动。在 此外，新的统计方法已经可用，例如线性 结构关系建模（Lisrel）可用于测试模型 描述大脑功能认知性能之间的关系。 旨在补充该培训计划的研究项目涉及 功能神经影像激活的开发和应用 检查神经系统介导的年轻人和老年人中记忆的技术 成年人。具体而言，候选人建议研究隐性技能 在年轻和老年人学习中学习。先前的认知研究 表明明确的内存始终受到衰老的损害，而 隐式内存的变化取决于所检查的特定函数。为了 实例，隐式记忆的研究表明，技能学习可能 老年人的下降，而其他类型的隐式记忆，例如 保留重复启动。研究的初始阶段 项目将包括脱机范式开发在线和老年人 受试者，随后用作宠物的激活技术 年轻（30-39）和老年人（70-79）成年人。后来的研究阶段 项目将涉及对类似学科的技能学习的评估 使用fMRI。此外，有些受试者将同时获得宠物和fMRI 在项目的此阶段，以提供直接数据 这两种技术的比较。 Lisrel分析将用于测试 大脑功能的模型，包括与衰老相关的功能变化。

项目成果

Strategic processing and episodic memory impairment in obsessive compulsive disorder.

强迫症中的策略处理和情景记忆障碍。

• DOI: 10.1037//0894-4105.14.1.141
• 发表时间: 2000
• 期刊: Neuropsychology.
• 作者: Savage,CR;Deckersbach,T;Wilhelm,S;Rauch,SL;Baer,L;Reid,T;Jenike,MA
• 通讯作者: Jenike,MA

Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning.

探索强迫症中的纹状体功能：内隐序列学习的 PET 研究。

• DOI: 10.1176/jnp.9.4.568
• 发表时间: 1997
• 期刊: The Journal of neuropsychiatry and clinical neurosciences
• 作者: Rauch,SL;Savage,CR;Alpert,NM;Dougherty,D;Kendrick,A;Curran,T;Brown,HD;Manzo,P;Fischman,AJ;Jenike,MA
• 通讯作者: Jenike,MA

Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?

症状出现的年龄与成人强迫症患者记忆障碍的严重程度是否相关？

• DOI: 10.1176/appi.ajp.158.1.137
• 发表时间: 2001
• 期刊: The American journal of psychiatry.
• 作者: Henin,A;Savage,CR;Rauch,SL;Deckersbach,T;Wilhelm,S;Baer,L;Otto,MW;Jenike,MA
• 通讯作者: Jenike,MA