Initial Biomedical Study of Turbidity Suppression by Optical Phase Conjugation

光相位共轭抑制浊度的初步生物医学研究

• 批准号: 7513395
• 负责人: CHANGHUEI YANG
• 金额: $ 20.5万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513395
• 关键词: Biomedical Technology; Biophotonics; Chickens; Dermal; Development; Exploratory/Developmental Grant; Funding; Goals; Implant; Investigation; Knowledge; Lead; Light; Methods; NIH Program Announcements; Optics; Phase; Photochemotherapy; Principal Investigator; Procedures; Process; Public Health; Research; System; Techniques; Therapeutic; Thick; Time; Tissues; Translating; Work; Yang; absorption; base; clinical Diagnosis; improved; innovation; novel; programs; research study

DESCRIPTION (provided by applicant): This Exploratory/Developmental Research (R21) application proposes to study the phenomenon of turbidity suppression optical phase conjugation (TS-OPC) and explore its uses for biomedical applications. TS-OPC - a biophotonic phenomenon recently observed by my group, is based on the use of optical phase conjugation to suppress tissue turbidity. Unlike absorption, elastic optical scattering is a time reversible process. As such, a time reversed copy of the scattered field should be able to retrace its trajectory through the scattering medium and recover the original light field. Our initial experiments revealed that this phenomenon is surprisingly robust - we were able to observe the phenomenon with a chicken tissue section of thickness 5mm and a wavelength of 532 nm. Our initial investigations also point to the potential utility of the method for several applications: optical powering of miniature sub-dermal implants, improving photodynamic therapy procedures, tissue absorption/scattering interrogation, etc. The focus of the proposed research is to attain a more complete understanding of the technique's working principle, streamline its implementation in reflection mode and begin initial investigations into its use for enhanced and targeted light delivery into tissues for photodynamic applications. The specific aims of the proposed research are: 1. Develop a quick, efficient and simple reflection mode TS-OPC system. 2. Experimentally determine the limits of the reflection mode TS-OPC method. 3. Develop a theoretical framework for understanding the TS-OPC method. 4. Begin initial investigations into the use of TS-OPC for enhanced and targeted light delivery into tissues - useful for photodynamics therapy (PDT). Narrative for Optical phase conjugation project PUBLIC HEALTH RELEVANCE: The phenomenon of turbidity suppression via optical phase conjugation can potentially be adapted for clinical diagnosis and therapeutics. The funding of the proposed research will allow us to better understand this newly discovered phenomenon and allow us to begin exploring one of its more promising applications - the enhancement of light delivery during photodynamic therapy procedures.

描述（由申请人提供）：这项探索/发展研究（R21）申请提出了研究浊度抑制光相结合（TS-OPC）的现象，并探索其在生物医学应用中的用途。 TS -OPC-我组最近观察到的一种生物光子现象是基于使用光相结合来抑制组织浊度的。与吸收不同，弹性光学散射是时间可逆的过程。因此，散射场的时间倒转副本应能够通过散射介质追溯其轨迹并恢复原始的光场。我们的最初实验表明，这种现象令人惊讶地稳健 - 我们能够观察到厚度为5mm的鸡肉组织段和波长为532 nm的现象。我们的初步研究还指出了该方法在多种应用中的潜在效用：微型亚源植入物的光学动力，改善光动力治疗程序，组织吸收/散射询问等。拟议的研究的重点是，最初的研究以使其对技术的实现进行更完整的了解，从而使其在培养原理中的实现，从而使其在整体上进行启动，从而使其在培养原理上进行了启动，并简化了其在整体上的实现，并将其简化为启动。申请。拟议研究的具体目的是：1。开发快速，高效和简单的反射模式TS-OPC系统。 2。实验确定反射模式TS-OPC方法的限制。 3。开发理论框架来理解TS-OPC方法。 4。开始对使用TS -OPC来增强和靶向光输送到组织的初步研究 - 对光动力学治疗（PDT）有用。光相结合项目公共卫生相关性的叙述：通过光相结合抑制浊度的现象，可能会适用于临床诊断和治疗剂。拟议的研究的资金将使我们能够更好地理解这种新发现的现象，并让我们开始探索其更有前途的应用之一 - 在光动力治疗程序期间发光的增强。