Colloidal Cell Delivery Systems

胶体细胞输送系统

• 批准号: EP/E02078X/1
• 负责人: Brian Saunders
• 金额: $ 10.27万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE02078X%2F1
• 关键词: Colloidal; Cell; Delivery; Systems

As stem cell technologies advance towards clinical application there is an urgent need to enhance the methods of delivering these cells into the body. Current methods of simple injection of cell suspensions are crude because they waste cells, compromise viability and generate poor starting conditions for the regeneration of a tissue. In this collaborative project between the universities of Nottingham and Manchester we will establish an injectable material consisting of a colloid mixture of cells and particles that is injectable at room temperature and aggregates into a porous colloidal gel at body temperature. This material could form the basis for cell delivery in neurology, endocrinology, hepatology, orthopaedics and many other areas because the components are well understood and trusted materials with long track records of use in the body. A successful outcome for this project will prove the principle of cell delivery into skeletal muscle tissue using temperature-triggered assembly and establish the fundamental principles involved.

随着干细胞技术向临床应用迈进，迫切需要增强将这些细胞输送到体内的方法。目前简单注射细胞悬浮液的方法很粗糙，因为它们浪费细胞、损害活力并且为组织再生产生不良的起始条件。在诺丁汉大学和曼彻斯特大学之间的这个合作项目中，我们将建立一种由细胞和颗粒的胶体混合物组成的可注射材料，该材料可在室温下注射并在体温下聚集成多孔胶体凝胶。这种材料可以成为神经病学、内分泌学、肝病学、骨科和许多其他领域细胞输送的基础，因为这些成分是众所周知且值得信赖的材料，在体内具有长期的使用记录。该项目的成功结果将证明使用温度触发组装将细胞输送到骨骼肌组织的原理，并建立所涉及的基本原理。

项目成果

Thermoresponsive copolymers: from fundamental studies to applications

热响应共聚物：从基础研究到应用

• DOI: http://dx.10.1007/s00396-009-2028-x
• 发表时间: 2009
• 期刊: Colloid and Polymer Science
• 影响因子: 2.4
• 作者: Liu R

Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system.

PLGA 分散体的热触发凝胶化：面向可注射胶体细胞输送系统。

• DOI: http://dx.10.1016/j.jcis.2009.12.030
• 发表时间: 2010
• 期刊: Journal of colloid and interface science
• 影响因子: 9.9
• 作者: Fraylich MR

Poly(D,L-lactide-co-glycolide) dispersions containing pluronics: from particle preparation to temperature-triggered aggregation.

含有 Pluronics 的聚（D,L-丙交酯-乙交酯）分散体：从颗粒制备到温度触发聚集。

• DOI: 10.1021/la800869u
• 发表时间: 2008-06-21
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Michael Fraylich;Wenxin Wang;K. Shakesheff;C. Ale;er;er;B. Saunders
• 通讯作者: B. Saunders

Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single-Step Process

使用一步法制备用于注射细胞递送的可生物降解的热响应微粒分散体

• DOI: http://dx.10.1002/adma.200800382
• 发表时间: 2009
• 期刊: Advanced Materials
• 影响因子: 29.4
• 作者: Wang W