pH-Responsive hollow particle gels for cartilage regeneration

用于软骨再生的 pH 响应性空心颗粒凝胶

• 批准号: EP/J009490/1
• 负责人: Brian Saunders
• 金额: $ 35.62万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ009490%2F1
• 关键词: pH; Responsive; hollow; particle; gels

Osteoarthritis (OA) is the gradual degeneration of cartilage covering the bony ends of joints. It is a debilitating disease which develops in 33% of adults in the mid 40s and affects 15% of the worlds population. The cost of OA treatment for the UK National Health Service (NHS) was £850M in 2007 (5% of the NHS budget) and is increasing. There is an urgent need for an injectable fluid that transforms into a gel in the body that provides both immediate load support to damaged cartilage and results in regeneration of cartilage tissue. Hollow polymer particles have potential to enable regeneration of cartilage tissue. In our proof-of-concept study we established a new injectable fluid containing pH-responsive biodegradable hollow polymer particles that change from a fluid to a gel at physiological conditions. In this proposal we aim to establish methods for linking the hollow particles together to prepare injectable gels that are both mechanically stable and are able to be disassembled on demand using molecules that naturally occur in the body. These are essential steps which, if successful, will result in design rules for preparing injectable, high strength, hollow particle gels that could enable a new OA therapy. This ambitious proposal greatly extends our earlier study and will be conducted by a postdoctoral research associate over a period of 30 months.

骨关节炎 (OA) 是一种覆盖关节骨端的软骨逐渐退化的疾病，有 33% 的 40 岁左右的成年人患有这种疾病，影响着世界上 15% 的人口。 2007 年，国家医疗服务 (NHS) 的预算为 8.5 亿英镑（占 NHS 预算的 5%），并且还在不断增加。迫切需要一种可改变的注射液。中空聚合物颗粒有可能使软骨组织再生，在我们的概念验证研究中，我们建立了一种新的可注射液体，其中含有。 pH 响应性可生物降解中空聚合物颗粒在生理条件下从流体转变为凝胶在本提案中，我们的目标是建立将中空颗粒连接在一起以制备机械稳定且可注射的凝胶的方法。能够根据需要使用体内自然存在的分子进行拆卸，如果成功，将产生用于制备可注射的高强度中空颗粒凝胶的设计规则，从而实现新的 OA 治疗。极大地扩展了我们早期的研究，并将由一名博士后研究员在 30 个月的时间内进行。

项目成果

Hydrogel Composites Containing Sacrificial Collapsed Hollow Particles as Dual Action pH-Responsive Biomaterials.

含有牺牲塌陷空心颗粒的水凝胶复合材料作为双作用 pH 响应生物材料。

• DOI: 10.1021/acs.biomac.6b00593
• 发表时间: 2016-06-16
• 期刊: Biomacromolecules
• 影响因子: 6.2
• 作者: Kyriaki S. Pafiti;Zhengxing Cui;D. Adlam;J. Hoyl;A. Freemont;B. Saunders
• 通讯作者: B. Saunders

Doubly crosslinked microgel-colloidosomes: a versatile method for pH-responsive capsule assembly using microgels as macro-crosslinkers.

双交联微凝胶-胶体体：一种使用微凝胶作为大交联剂组装 pH 响应胶囊的通用方法。

• DOI: 10.1039/c4cc10169c
• 发表时间: 2015-02-17
• 期刊: Chemical communications
• 影响因子: 4.9
• 作者: Wenkai Wang;Amir H. Milani;Louise Carney;Junfeng Yan;Zhengxing Cui;S. Thaiboonrod;B. Saunders
• 通讯作者: B. Saunders

Gel architectures and their complexity

凝胶结构及其复杂性

• DOI: http://dx.10.1039/c4sm00208c
• 发表时间: 2014
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Richtering W

Double network hydrogels prepared from pH-responsive doubly crosslinked microgels

pH响应性双交联微凝胶制备双网络水凝胶

• DOI: http://dx.10.1039/c3sm51356d
• 发表时间: 2013
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Lane T

pH-responsive physical gels from poly(meth)acrylic acid-containing crosslinked particles: the relationship between structure and mechanical properties

含聚（甲基）丙烯酸交联颗粒的 pH 响应型物理凝胶：结构与机械性能之间的关系

• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Silvia S. Halacheva (Author)