Neurocognitive Correlates of Behavior Treatment Response in Child TS

儿童 TS 行为治疗反应的神经认知相关性

• 批准号: 7483602
• 负责人: Susanna W. Chang
• 金额: $ 13.33万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483602
• 关键词: Adolescent; Affect; Affective; Age; Applied Research; Area; Attention; Attention deficit hyperactivity disorder; Award; Awareness; Behavior; Behavior Therapy; Behavioral; Child; Childhood; Childhood Tic Disorders; Clinical Research; Clinical Treatment; Cognition; Cognitive; Cognitive deficits; Condition; Control Groups; Corpus striatum structure; Data; Decision Making; Development; Diagnostic; Discrimination; Disease; Disease model; Distress; Doctor of Philosophy; Educational Activities; Emotional; Encapsulated; Environmental Risk Factor; Etiology; Evolution; Exhibits; Frustration; Functional disorder; Funding; Genetic; Gilles de la Tourette syndrome; Goals; Habits; Impairment; Impulsivity; Intervention; Intervention Studies; Investigation; Judgment; Lead; Lesion; Link; Measures; Medial; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentors; Mink; Modeling; Motor; Nature; Neurobiology; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neuropsychology; Neurosciences Research; Obsessive-Compulsive Disorder; Patients; Pattern; Pediatric Research; Performance; Population; Prefrontal Cortex; Prevalence; Problem Solving; Process; Psychological reinforcement; Rage; Reaction Time; Reading; Regulation; Relative (related person); Research; Research Design; Research Personnel; Research Project Grants; Rewards; Risk; Risk-Taking; Sampling; School-Age Population; Self-Injurious Behavior; Severities; Signal Transduction; Social Discrimination; Stimulus; Surveys; Teenagers; Testing; Therapeutic; Thinking; Tic disorder; Training; Treatment Efficacy; Vocal Tics; Waxes; Week; Wood material; abstracting; analog; base; design; early childhood; executive function; improved; indexing; mood regulation; neurobehavioral disorder; neuroimaging; neuropsychiatry; neuropsychological; psychosocial; response; skills; therapy development; treatment effect; week trial

DESCRIPTION (provided by applicant): The long-term objectives of this Mentored Patient-Oriented Research Career Development Award are to provide the applicant with the conceptual background and research skills necessary to develop into an independent investigator in the field of translational interventions research with child neuropsychiatric disorders. The applicant's primary goal is to gain proficiency in the research of pediatric Tourette Syndrome (TS), specifically in the integration of neurocognitive paradigms with empirically validated behavior treatments to elucidate the cognitive mechanisms underlying treatment response. To accomplish this goal, the candidate will be mentored by experts in the fields of child TS assessment and treatment, neuropsychology of psychiatric populations, cognitive and developmental neuroscience, research design, and biostatisics. She will participate in didactic training including formal coursework and other educational activities in these relevant training areas. The award's research project investigates neurocognitive functioning in child TS before and after behavior intervention for tics, with the overarching goal of exploring the hypothesis that cognitive tasks sensitive to frontal-striatal dysfunction are implicated in the etiology and presentation of pediatric TS. As an adjunct to UCLA's NIMH-funded Center for Intervention Development and Applied Research, the proposed study will examine response inhibition, affect regulation, and risky decision-making performance before and after an eight-session trial of an empirically validated behavioral treatment (Habit Reversal Training) in 20 children with TS compared to 20 TS waitlist control subjects. We hypothesize that at baseline, TS children will have greater impairments in neurocognitive functioning than a sample of age-matched healthy controls. Furthermore, neurocognitive indices will be used to predict and probe clinical treatment effects reflected by tic severity variables. The association between neurocognitive indices and psychosocial function will also be explored. To date, there have been few studies of child TS neurocognition from both response inhibition and affective/motivational perspectives in conjunction with a focus on treatment development. The understanding and modeling of mechanisms underlying cognitive deficits in disorders such as TS may lead to the development of targeted and more efficacious treatments to enhance cognition in children who share a similar profile of impairment.

描述（由申请人提供）：这项受过指导患者的研究职业发展奖的长期目标是为申请人提供与儿童神经精神疾病的转化干预研究领域中独立研究者所必需的概念背景和研究技能。申请人的主要目标是熟练地研究小儿图雷特综合征（TS），特别是将神经认知范式与经验验证的行为治疗的整合在一起，以阐明治疗反应的认知机制。为了实现这一目标，候选人将受到儿童TS评估和治疗领域的专家的指导，精神病学人群的神经心理学，认知和发展性神经科学，研究设计和生物统计学。她将参加这些相关培训领域的教学培训，包括正式课程和其他教育活动。该奖项的研究项目调查了TICS行为干预前后的神经认知功能，其总体目的是探讨以下假设：对额 - 纹状体功能障碍敏感的认知任务与儿童TS的病因和表现有关。作为UCLA由NIMH资助的干预开发和应用研究中心的辅助，该研究将检查20个TS侍应生对照受试者的八次经验验证的行为治疗（习惯逆转培训）的八次经验验证的行为治疗（习惯逆转培训）的反应抑制，影响调节和危险的决策绩效。我们假设在基线时，与年龄匹配的健康对照样本相比，TS儿童在神经认知功能方面的损害更大。此外，神经认知指数将用于预测和探测由TIC严重性变量反映的临床治疗效果。神经认知指数与社会心理功能之间的关联也将被探讨。迄今为止，从反应抑制和情感/动机的观点以及关注治疗发展的研究中，很少有关于儿童TS神经认知的研究。 TS等疾病中认知缺陷的机制的理解和建模可能会导致靶向和更有效的治疗方法的发展，以增强具有相似障碍概况的儿童的认知。