Minority Predoctoral

少数民族博士前

• 批准号: 7385059
• 负责人: ALICIA M ORTEGA
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-13 至 2009-05-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385059
• 关键词: Area; Behavior; Bos taurus; Cattle; Cells; Chemicals; Chemistry; Condition; Coupled; Development; Devices; Drug Delivery Systems; Failure; Glass; Goals; In Vitro; Invasive; Knowledge; Length; Link; Mechanics; Memory; Minority; Modeling; Modification; Molecular Weight; Operative Surgical Procedures; Orthopedic Fixation Devices; Orthopedics; Performance; Pharmaceutical Preparations; Polymers; Production; Property; Rate; Recovery; Research; Shapes; Stress; Structure; System; Technology; Tendon structure; Testing; Therapeutic; Tissue Engineering; Transition Temperature; Vertebral column; Work; base; bone; crosslink; density; design; experience; implantation; in vitro Model; in vivo; next generation; novel; pre-doctoral; response; scaffold; tissue support frame

The objective of this research is to develop novel deployable biodegradable orthopedic fixation devices from shape memory polymer networks. The technology would replace current screw type orthopedic fixation devices with a "smart plug" capable of deploying and fixing tendons in bone in a simple, reliable, and minimally invasive manner. A fundamental understanding of the link between the chemical/physical structure of a representative polymer network and its thermo-mechanical and shape-memory properties will be developed. Necessary modifications to the polymer structure, to make the system biodegradable, will be studied, as will the structural and mechanical effects on the degradation rate. The effect of degradation on the shape-memory response of the material will be analyzed to gain understanding of the long-term storage and deployment issues of the biodegradable shape-memory polymer. These studies will enable the design of an optimal polymer system for use in the next generation of orthopedic fixation devices. In-vitro testing of the devices will allow for the determination of performance of the devices in use. Finally, the addition of cell and therapeutic drug encapsulation in the polymer structure will be explored.

这项研究的目的是从 形状内存聚合物网络。该技术将取代当前的螺丝型骨科固定 具有“智能插头”的设备，能够在简单，可靠和 微创方式。对化学/物理之间联系的基本理解 代表性聚合物网络的结构及其热力学和形状内存性能将 被开发。对聚合物结构进行必要的修改，以使系统可生物降解，将是 研究了，结构和机械对降解速率的影响也会进行。退化对 将分析材料的形状内存响应，以了解长期存储 以及可生物降解形状内存聚合物的部署问题。这些研究将使设计 最佳聚合物系统用于下一代骨科固定设备。体外测试 这些设备将允许确定使用中的设备的性能。最后，添加细胞 将探索聚合物结构中的治疗药物封装。