Minority Predoctoral

少数民族博士前

• 批准号: 7385059
• 负责人: ALICIA M ORTEGA
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-13 至 2009-05-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385059
• 关键词: Area; Behavior; Bos taurus; Cattle; Cells; Chemicals; Chemistry; Condition; Coupled; Development; Devices; Drug Delivery Systems; Failure; Glass; Goals; In Vitro; Invasive; Knowledge; Length; Link; Mechanics; Memory; Minority; Modeling; Modification; Molecular Weight; Operative Surgical Procedures; Orthopedic Fixation Devices; Orthopedics; Performance; Pharmaceutical Preparations; Polymers; Production; Property; Rate; Recovery; Research; Shapes; Stress; Structure; System; Technology; Tendon structure; Testing; Therapeutic; Tissue Engineering; Transition Temperature; Vertebral column; Work; base; bone; crosslink; density; design; experience; implantation; in vitro Model; in vivo; next generation; novel; pre-doctoral; response; scaffold; tissue support frame

The objective of this research is to develop novel deployable biodegradable orthopedic fixation devices from shape memory polymer networks. The technology would replace current screw type orthopedic fixation devices with a "smart plug" capable of deploying and fixing tendons in bone in a simple, reliable, and minimally invasive manner. A fundamental understanding of the link between the chemical/physical structure of a representative polymer network and its thermo-mechanical and shape-memory properties will be developed. Necessary modifications to the polymer structure, to make the system biodegradable, will be studied, as will the structural and mechanical effects on the degradation rate. The effect of degradation on the shape-memory response of the material will be analyzed to gain understanding of the long-term storage and deployment issues of the biodegradable shape-memory polymer. These studies will enable the design of an optimal polymer system for use in the next generation of orthopedic fixation devices. In-vitro testing of the devices will allow for the determination of performance of the devices in use. Finally, the addition of cell and therapeutic drug encapsulation in the polymer structure will be explored.

本研究的目的是开发新型可部署的可生物降解的骨科固定装置 形状记忆聚合物网络。该技术将取代目前的螺钉式骨科固定装置 带有“智能插头”的设备能够以简单、可靠和可靠的方式在骨骼中部署和固定肌腱 微创方式。对化学/物理之间的联系有基本的了解 代表性聚合物网络的结构及其热机械和形状记忆特性将 得到开发。为了使系统可生物降解，需要对聚合物结构进行必要的修饰 研究了结构和机械对降解率的影响。降解的影响 将分析材料的形状记忆响应，以了解长期存储的情况 以及可生物降解形状记忆聚合物的部署问题。这些研究将使设计成为可能 用于下一代骨科固定装置的最佳聚合物系统的研究。体外测试 这些设备将允许确定正在使用的设备的性能。最后添加细胞 并将探索聚合物结构中的治疗药物封装。