Minority Predoctoral

少数民族博士前

• 批准号: 7062625
• 负责人: ALICIA M ORTEGA
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-13 至 2009-02-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062625
• 关键词: assistive device /technology; biodegradable product; bioengineering /biomedical engineering; biomaterial development /preparation; chemical structure function; drug delivery systems; medical rehabilitation related tag; physical chemical interaction; polymerization; polymers; predoctoral investigator; thermodynamics; tissue engineering; tissue support frame

DESCRIPTION (provided by applicant): The objective of this research is to develop novel deployable biodegradable orthopedic fixation devices from shape memory polymer networks. The technology would replace current screw type orthopedic fixation devices with a "smart plug" capable of deploying and fixing tendons in bone in a simple, reliable, and minimally invasive manner. A fundamental understanding of the link between the chemical/physical structure of a representative polymer network and its thermo-mechanical and shape-memory properties will be developed. Necessary modifications to the polymer structure, to make the system biodegradable, will be studied, as will the structural and mechanical effects on the degradation rate. The effect of degradation on the shape-memory response of the material will be analyzed to gain understanding of the long-term storage and deployment issues of the biodegradable shape-memory polymer. These studies will enable the design of an optimal polymer system for use in the next generation of orthopedic fixation devices. In-vitro testing of the devices will allow for the determination of performance of the devices in use. Finally, the addition of cell and therapeutic drug encapsulation in the polymer structure will be explored.

描述（由申请人提供）：本研究的目的是利用形状记忆聚合物网络开发新型可部署的可生物降解的骨科固定装置。该技术将用“智能插头”取代当前的螺钉式骨科固定装置，能够以简单、可靠和微创的方式将肌腱部署和固定在骨骼中。将加深对代表性聚合物网络的化学/物理结构与其热机械和形状记忆特性之间联系的基本理解。将研究对聚合物结构进行必要的修饰以使系统可生物降解，以及结构和机械对降解速率的影响。将分析降解对材料形状记忆响应的影响，以了解可生物降解形状记忆聚合物的长期储存和部署问题。这些研究将使设计用于下一代骨科固定装置的最佳聚合物系统成为可能。设备的体外测试将允许确定设备在使用中的性能。最后，将探索在聚合物结构中添加细胞和治疗药物封装。