Polymer/Ceramic Composites for Tissue Engineering

用于组织工程的聚合物/陶瓷复合材料

• 批准号: 7124761
• 负责人: CATO T. LAURENCIN
• 金额: $ 27.73万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124761
• 关键词: biodegradable product; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biotechnology; ceramics; chemical synthesis; cytotoxicity; hydroxyapatites; laboratory rabbit; laboratory rat; microcapsule; osteoblasts; polymers; substantia spongiosa; tissue /cell culture; tissue engineering; tissue support frame

DESCRIPTION (provided by applicant): Tissue engineering has developed into a truly interdisciplinary field offering promises to revitalize or replace damaged or lost human tissue/organs. Tissue engineering has been defined as the application of biological, chemical and engineering principles toward the repair, restoration or regeneration of living tissue using biomaterials, cells and factors alone or in combination. The major components of tissue engineered products are the three dimensional scaffold with/without factors and the appropriate cells. Bone tissue engineering requires scaffolds with optimal properties that include strength, toughness, porosity, controlled rate of degradation, non-toxic degradation products, minimal inflammatory response, moldability, osteoconductivity and osteoinductivity. In the proposed work, we will focus on the development of novel three-dimensional (3-D) composite scaffolds with optimal properties for bone tissue engineering. Composite matrices will be made from novel polymers based on polyphosphazenes and hydroxyapatite (HA). We hypothesize that these 3-D composites, which combine the controlled degradation rate, biocompatibility and osteoconductivity of polyphosphazenes with the bioactivity of HA, can eventually mimic the biological and mechanical properties of bone, which itself is a composite. The overall goal is to design and develop three-dimensional scaffolds with controlled physico-chemical and biological properties that will be a practical alternative to current bone repair materials. This goal will be achieved via the following specific aims: Specific Aim 1: The design, synthesis, and characterization of novel biodegradable polyphosphazenes with appropriate thermal, biological and mechanical properties that can be processed with HA to form 3-dimensional matrices. Specific Aim 2: Development of novel 3-dimensional polyphosphazene-HA based composite matrices and evaluation of the biological and mechanical properties of the composites using in vitro techniques. Specific Aim 3: Evaluation of the biological performance of novel 3-D composite matrices using in vivo techniques.

描述（由申请人提供）：组织工程已发展为真正的跨学科领域，提供有望振兴或替代受损或损失的人体组织/器官的承诺。组织工程被定义为使用生物材料，细胞和单独或组合使用生物学，化学和工程原理在维修，恢复或再生中的应用。组织工程产品的主要组成部分是具有/没有因素和适当细胞的三维支架。骨组织工程需要具有最佳特性的脚手架，包括强度，韧性，孔隙率，降解速率，无毒降解产物，最小的炎症反应，可感染性，破骨率和骨诱导性。在拟议的工作中，我们将重点关注具有骨组织工程具有最佳特性的新型三维（3-D）复合支架的发展。复合基质将由基于多磷烯和羟基磷灰石（HA）的新型聚合物制成。我们假设这些3-D复合材料结合了受控降解速率，聚磷酸的生物相容性和骨传导性与HA的生物活性，最终可以模仿骨的生物学和机械性能，而骨本身就是一种复合材料。 总体目标是设计和开发具有控制的物理化学和生物学特性的三维脚手架，这将是当前骨修复材料的实际替代方法。该目标将通过以下特定目的实现： 具体目标1：具有适当的热，生物学和机械性能的新型可生物降解的多磷烯的设计，合成和表征，可以与HA一起处理以形成3维矩阵。 具体目标2：基于新型三维聚磷酸-HA的复合矩阵的发展，并使用体外技术评估复合材料的生物学和机械性能。 特定目的3：使用体内技术评估新型3-D复合矩阵的生物学性能。