The Respiratory-motor Coupling

呼吸运动耦合

• 批准号: 7663066
• 负责人: Sheng Li
• 金额: $ 21.67万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7663066
• 关键词: Area; Breathing; Cognitive; Coupling; Data; Development; Distal; Elbow; Electric Stimulation; Fingers; Flexor; Goals; Impairment; Isometric Exercise; Knee; Mechanics; Mediating; Morphologic artifacts; Motor; Motor output; Movement; Muscle; Outcome; Phase; Physiological; Production; Reaction Time; Rehabilitation therapy; Research; Respiration; Respiratory Muscles; Rest; Secondary to; Shoulder; Skeletal Muscle; Spinal; Stimulus; Stroke; Testing; Time; Transcranial magnetic stimulation; base; clinical application; expiration; muscle strength; neuromuscular; neurophysiology; novel therapeutic intervention; public health relevance; relating to nervous system; respiratory; response; stroke rehabilitation; tool

DESCRIPTION (provided by applicant): The primary focus is to examine the neurophysiologic basis of the respiratory-motor coupling and to rule out potential alternatives. We hypothesize that there is a finger flexion-expiration, finger extension-inspiration coupling. The neurophysiologic basis for this coupling is that forced expiration enhances corticospinal excitability for the finger flexors and finger extensors, while forced inspiration enhances activation primarily for the finger extensors. To test the hypothesis, we will quantify changes in corticospinal excitability associated with voluntary breathing (Aim 1) using transcranial magnetic stimulation (TMS) and neuromuscular electrical stimulation (ES) in a variety of tasks in normal subjects. In Aim 2, we will investigate potential alternative mechanisms that the voluntary breathing effects are artifacts of mechanical transfer or of dual tasking. Collectively, outcomes of this project are likely to provide evidence for the intrinsic neurophysiologic basis of the finger flexion-expiration, finger extension-inspiration coupling. The long-term goal is to apply the intrinsic physiological coupling between voluntary breathing and finger muscles to rehabilitation of finger extension impairment after stroke, e.g. electrical stimulation delivered to the finger extensors on the inspiratory phase of voluntary breathing is expected to maximize the stimulation effect. PUBLIC HEALTH RELEVANCE: The proposed research examines underlying neurophysiologic mechanisms of the respiratory-motor coupling using non-invasive tools will be used, such as transcranial magnetic stimulation (TMS) and neuromuscular electrical stimulation (ES). The potential alternative mechanisms will be ruled out. Potential clinical applications of this newly discovered phenomenon for stroke rehabilitation are demonstrated.

描述（由申请人提供）：主要重点是检查呼吸运动耦合的神经生理学基础并排除潜在的替代方案。我们假设存在手指屈曲-呼气、手指伸展-吸气耦合。这种耦合的神经生理学基础是，用力呼气增强了手指屈肌和手指伸肌的皮质脊髓兴奋性，而用力吸气则主要增强了手指伸肌的激活性。为了检验这一假设，我们将在正常受试者的各种任务中使用经颅磁刺激 (TMS) 和神经肌肉电刺激 (ES) 来量化与自主呼吸（目标 1）相关的皮质脊髓兴奋性的变化。在目标 2 中，我们将研究潜在的替代机制，即自主呼吸效应是机械转移或双重任务的产物。总的来说，该项目的结果可能为手指屈曲-呼气、手指伸展-吸气耦合的内在神经生理学基础提供证据。长期目标是将自主呼吸和手指肌肉之间的内在生理耦合应用于中风后手指伸展损伤的康复，例如手指伸展损伤。在自主呼吸的吸气阶段向手指伸肌施加电刺激预计可以最大限度地提高刺激效果。公共健康相关性：拟议的研究将使用非侵入性工具，例如经颅磁刺激（TMS）和神经肌肉电刺激（ES），检查呼吸运动耦合的潜在神经生理机制。潜在的替代机制将被排除。证明了这种新发现的中风康复现象的潜在临床应用。