CORE--CLINICAL CORE

核心--临床核心

• 批准号: 6933383
• 负责人: NORMAN LOUIS FOSTER
• 金额: $ 29.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933383
• 关键词: Alzheimer' s disease; aging; biomedical facility; brain disorder diagnosis; clinical research; dementia; disease /disorder classification; human data; human subject; longitudinal human study; medical outreach /case finding; medical records; neuropathology; neuropsychological tests; pathologic process; patient /disease registry; positron emission tomography; postmortem; psychomotor function

The Clinical Core provides well-characterized patients and control subjects for novel interdisciplinary research in Center-related and collaborative projects. New subjects added to the current Longitudinal Case Series will include only persons with normal aging and patients with mild cognitive impairment (MCI) or mild dementia. This will meet the needs of Center investigators and allow them to conduct cutting-edge research to understand better the clinical and neuropathological changes that distinguish the earliest stages of Alzheimer's disease (AD) from normal aging and from other neurodegenerative diseases commonly seen in the elderly. All subjects receive comprehensive examinations, including neuropsychological, laboratory and imaging studies, and are classified at a consensus conference using explicit diagnostic inclusion and exclusion criteria. Subjects identify a study partner who serves as an informant and are encouraged to name a health care advocate and give provisional consent for an autopsy to facilitate research. Annual assessments provide longitudinal clinical and neuropsychological data. The Core refers potential subjects to clinical research projects, shares data with the National Alzheimer's Coordinating Center, and collects biological samples following agreed upon protocols for multi-center projects. In close collaboration with the Education Core, the Clinical Core serves as the primary contact point with the community and assists with educational materials and activities to promote participation in clinical studies, stimulate the interest of trainees and new investigators, and disseminate research advances widely. In conjunction with the Minority Satellite Diagnostic and Treatment Center at the Ypsilanti Family Practice Center, which serves large African-American and Hispanic communities, the Clinical Core ensures a diverse research population from which to draw potential subjects. The Core also performs developmental work using its collected longitudinal data to provide Center investigators with metrics describing individual clinical transitions and rate of disease progression in enrolled participants.

临床核心为新颖的研究提供了特征良好的患者和对照受试者 中心相关和合作项目的跨学科研究。当前纵向病例系列中添加的新受试者将仅包括正常衰老的人以及患有轻度认知障碍（MCI）或轻度痴呆的患者。这将满足中心研究人员的需求，并使他们能够进行前沿研究，以更好地了解临床和神经病理学变化，从而将阿尔茨海默病（AD）的早期阶段与正常衰老和老年人常见的其他神经退行性疾病区分开来。所有受试者均接受全面检查，包括神经心理学、实验室和影像学研究，并在共识会议上使用明确的诊断纳入和排除标准进行分类。受试者确定一名作为线人的研究伙伴，并鼓励受试者指定一名医疗保健倡导者并暂时同意尸检以促进研究。年度评估提供纵向临床和神经心理学数据。核心将潜在受试者推荐给临床研究项目，与 国家阿尔茨海默病协调中心，并按照商定的多中心项目协议收集生物样本。临床核心与教育核心密切合作，作为与社区的主要联系点，协助提供教育材料和活动，以促进临床研究的参与，激发学员和新研究人员的兴趣，并广泛传播研究进展。临床核心与为大型非裔美国人和西班牙裔社区服务的伊普西兰蒂家庭实践中心的少数民族卫星诊断和治疗中心相结合，确保了多样化的研究人群，从中吸引潜在的受试者。核心还利用其收集的纵向数据开展开发工作，为中心研究人员提供 描述登记参与者的个体临床转变和疾病进展率的指标。