Diabetes, Obesity and Metabolism

糖尿病、肥胖和新陈代谢

• 批准号: 7439708
• 负责人: Michael W Schwartz
• 金额: $ 35.07万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7439708
• 关键词: Diabetes Mellitus; Metabolism; Obesity

DESCRIPTION (provided by applicant): This training grant provides research training that will allow M.D., Ph.D., and M.D./Ph.D postdoctoral fellows to become independent investigators in the fields of diabetes, obesity, and metabolism. Research training will be provided by a large group of highly skilled and experienced investigators at the University of Washington and affiliated institutions who will serve as preceptors. Based on 1) the continued outstanding success of this program and large numbers of applicants, 2) an expanded emphasis on basic science aspects of obesity and diabetes, 3) a major new commitment from the University of Washington to create and support a Diabetes and Obesity Center of Excellence in a new research campus, and 4) a substantial increase in the size of our program faculty, we request an increase in the number of training slots from four to six. M.D. candidates will have completed residency training as well as a first, clinical year of fellowship prior to funding via this program. This arrangement allows both M.D. and Ph.D. fellows to spend at least 80% of their time on research activities while they are supported by this training grant. Selection of fellow applicants will be done by the Fellowship Training Executive Committee, and will benefit from a large pool of qualified candidates who apply to the Division of Metabolism, Endocrinology and Nutrition at the University of Washington for their research training. Among the criteria for selection are 1) a strong interest in the fields of diabetes, obesity and glucose or energy metabolism (frequently accompanied by previous research experience) and 2) demonstrated potential for a successful research career. This program provides trainees with research experience in both basic and clinical aspects of diabetes and obesity, with special emphasis on molecular and cell biology, physiology, and translational research. Research training will be complemented by didactic lectures and seminars that cover diabetes, obesity, glucose homeostasis, energy metabolism and related aspects of endocrinology, with additional seminars on scientific methods, manuscript preparation, grantsmanship, and biomedical ethics. Diabetes and obesity are among the most pressing public health concerns. Despite impressive advances at the basic science level, major unanswered questions regarding the pathogenesis of these disorders continue to limit our capacity to treat them. Effective training for scientists in obesity and diabetes is therefore a fundamental priority.

描述（由申请人提供）： 这笔培训补助金提供研究培训，使医学博士、哲学博士和医学博士/博士后研究员能够成为糖尿病、肥胖和代谢领域的独立研究人员。研究培训将由华盛顿大学及其附属机构的一大批技术精湛、经验丰富的研究人员提供，他们将担任导师。基于 1) 该计划持续取得的巨大成功和大量申请者，2) 对肥胖和糖尿病基础科学方面的更多重视，3) 华盛顿大学新的重大承诺，创建和支持糖尿病和肥胖研究中心卓越中心位于新的研究园区，4）我们的项目教师规模大幅增加，我们要求将培训名额从四个增加到六个。 医学博士候选人在通过该计划获得资助之前将完成住院医师培训以及第一年的临床研究金。这种安排允许医学博士和博士学位。在获得培训补助金的支持期间，研究员将至少 80% 的时间用于研究活动。奖学金培训执行委员会将筛选其他申请人，并将受益于申请华盛顿大学代谢、内分泌和营养学部接受研究培训的大量合格候选人。选择标准包括：1) 对糖尿病、肥胖症和葡萄糖或能量代谢领域有浓厚兴趣（通常伴有之前的研究经验）；2) 表现出成功研究生涯的潜力。 该项目为学员提供糖尿病和肥胖症基础和临床方面的研究经验，特别强调分子和细胞生物学、生理学和转化研究。研究培训将辅以涵盖糖尿病、肥胖、葡萄糖稳态、能量代谢和内分泌学相关方面的教学讲座和研讨会，以及有关科学方法、稿件准备、资助和生物医学伦理学的额外研讨会。 糖尿病和肥胖是最紧迫的公共卫生问题之一。尽管基础科学水平取得了令人印象深刻的进步，但有关这些疾病发病机制的主要未解答问题仍然限制了我们治疗它们的能力。因此，对肥胖和糖尿病领域的科学家进行有效培训是首要任务。