Objective Physical Activity and Cardiovascular Health in Women Aged 80 and Older

80 岁及以上女性的客观体力活动和心血管健康

基本信息

批准号：
8324552
负责人：
ANDREA Z. LACROIX
金额：
$ 172.68万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8324552
关键词：
Address Aerobic African American Age Alzheimer&apos s Disease American Americas Biological Markers Calibration Cardiovascular system Censuses Clinic Clinic Visits Colon Carcinoma Data Dementia Devices Elderly Energy Metabolism Enrollment Event Female Frequencies Future Guidelines Health Health Benefit Health Policy Hispanics Hour Indirect Calorimetry Inflammatory Injury Label Latino Life Expectancy Light Light Exercise Measurement Measures Medicare Minority Non-Insulin-Dependent Diabetes Mellitus Outcome Outcome Study Parents Participant Patient Self-Report Pattern Physical activity Physical activity scale Population Prospective Studies Public Health Public Policy Questionnaires Recruitment Activity Reporting Research Research Design Rice Risk Sample Size Societies Stroke Time United States Visit Walking Water Woman Women&apos s Health age related aged beneficiary cancer type cardiovascular risk factor cognitive function cohort disability evidence base falls healthy aging malignant breast neoplasm mortality older women sedentary statistics web site

项目摘要

DESCRIPTION (provided by applicant): The purpose of this four year project is to determine how much, how vigorous and what patterns of physical activity are necessary to maintain cardiovascular health among older women. Accelerometers will be used to characterize the amounts and patterns of physical activity. In a cohort of 8000 WHI participants aged 80 and older we will: 1) Determine the association of total volume of physical activity (light, moderate and vigorous) as measured by accelerometry with rates of incident CVD and total mortality; 2) Determine the associations of moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with rates of incident CVD and total mortality; 2.1) Conduct a calibration study designed to determine accelerometry thresholds for women aged 80 and older that distinguish sedentary from light activity and light activity from moderate to vigorous activity in order to make Aim 2 directly relevant to older women; 3) Compare the magnitude and independence of associations between accelerometer measures of physical activity and sedentary time, and self-reported measures of MVPA and sedentary time, with rates of incident CVD and total mortality; and 4) Determine associations of total volume of physical activity, MVPA and sedentary time with rates of fall-related injuries and overall risk for any injury. To accomplish these aims, 8,000 face-to-face visits will be conducted nationwide among women aged 80 and older from the Women's Health Initiative (WHI) who were originally enrolled between 1993-1997. Participants will wear an accelerometer for 7 days, complete a questionnaire containing the CHAMPS and WHI physical activity scales, and the Falls Efficacy Scale, and be followed through at least 2015 (3-4 years) to ascertain study outcomes. For the calibration study, two WHI clinics will recruit 200 women for participation in a clinic visit to measure energy expenditure during various activities using indirect calorimetry. This evidence is crucial for formulating evidence-based physical activity guidelines that pertain to the growing population of older women in the US and worldwide.

描述（由申请人提供）：这个为期四年的项目的目的是确定老年女性维持心血管健康所需的体力活动量、强度和模式。加速度计将用于表征身体活动的数量和模式。在由 8000 名 80 岁及以上 WHI 参与者组成的队列中，我们将： 1) 确定通过加速度计测量的体力活动总量（轻度、中度和剧烈）与 CVD 发生率和总死亡率之间的关联； 2) 确定中等至剧烈强度体力活动 (MVPA) 和久坐时间与 CVD 发生率和总死亡率之间的关系； 2.1) 开展一项校准研究，旨在确定 80 岁及以上女性的加速度阈值，区分久坐与轻度活动以及轻度活动与中度至剧烈活动，以使目标 2 与老年女性直接相关； 3) 比较体力活动和久坐时间的加速度计测量值以及 MVPA 和久坐时间的自我报告测量值与 CVD 发生率和总死亡率之间关联的大小和独立性； 4) 确定体力活动总量、MVPA 和久坐时间与跌倒相关伤害发生率和任何伤害总体风险之间的关系。为了实现这些目标，将在全国范围内对来自妇女健康倡议 (WHI) 的 80 岁及以上妇女进行 8,000 次面对面访问，这些妇女最初是在 1993 年至 1997 年间加入的。参与者将佩戴加速度计 7 天，完成包含 CHAMPS 和 WHI 身体活动量表以及跌倒功效量表的调查问卷，并至少跟踪 2015 年（3-4 年）以确定研究结果。对于校准研究，两家 WHI 诊所将招募 200 名女性参加诊所访问，以使用间接量热法测量各种活动期间的能量消耗。这一证据对于制定针对美国和世界范围内不断增长的老年女性人口的循证身体活动指南至关重要。