Age-Related Odor Memory Impairment in a Rodent Model

啮齿动物模型中与年龄相关的气味记忆损伤

• 批准号: 7385027
• 负责人: PAUL E GILBERT
• 金额: $ 19.36万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385027
• 关键词: Affect; Age; Age-Years; Aging; Alzheimer' s Disease; Animal Cancer Model; Animal Model; Brain; Classification; Condition; Discrimination; Elderly; Flavoring; Future; Grant; Human; Impaired cognition; Impairment; Learning; Measures; Memory; Memory impairment; Modality; Modeling; Numbers; Odors; Performance; Rate; Rattus; Research; Research Personnel; Reversal Learning; Rewards; Rodent Model; Sampling; Score; Sensory; Short-Term Memory; Stimulus; Testing; Visual; Work; age effect; age related; aged; classical conditioning; insight; neurochemistry; normal aging; olfactory stimulus; preference; programs; research study; visual memory; visual stimulus

Research in healthy humans over 65 years of age shows greater impairments in learning and memory for olfactory stimuli than visual stimuli. Other studies strongly suggest that problems with remembering and detecting odors may be an early indication of cognitive impairment and Alzheimer's disease. Studies involving aged rats have offered insight into how brain changes associated with aging may result in impaired cognition. However, very little research has examined odor memory in aged rats. The few existing studies investigating odor memory impairments associated with aging in rats have not made direct comparisons with memory for stimuli from a different sensory modality. As a result, it is unknown whether odor memory is any more or less affected by aging than memory for stimuli encoded via other sensory modalities. Therefore, it is unclear whether aging rats are a good model for understanding how age related brain changes might result in impairments in odor memory in older humans. The primary aim of this grant is to investigate the effects of normal aging on memory for olfactory stimuli using an animal model. Specific aim 1 will investigate age- related differences in discrimination and reversal learning for olfactory and visual stimuli. Specific Aim 2 will investigate age-related differences in working memory for olfactory and visual stimuli. Specific Aim 3 will investigate age-related differences in associative learning for olfactory and visual stimuli. The proposed experiments will determine whether odor memory is more affected than visual memory in aged rats. The results of the experiments will offer valuable insight into whether aging has a similar deleterious effect on odor memory in rats and in humans. Furthermore, the findings will suggest whether aged rats are a good animal model for studying the effects of aging on odor memory in older humans. In addition, the results will illustrate how memory for stimuli encoding via different sensory modalities may be differentially affected by aging and how increasing age may differentially affect different types of memory. The findings may have important implications for the selection of memory paradigms for future research studies on aging. The use of an animal model to investigate the effects of aging on odor memory will allow researchers the ability investigate how age-related neuroanatomical and neurochemical changes may result in impaired odor memory.

对 65 岁以上健康人的研究表明，学习和记忆能力受损更大 嗅觉刺激多于视觉刺激。其他研究强烈表明，记忆和记忆问题 检测气味可能是认知障碍和阿尔茨海默病的早期迹象。研究 涉及老年老鼠的研究提供了关于与衰老相关的大脑变化如何导致受损的见解 认识。然而，很少有研究检查老年大鼠的气味记忆。现有研究为数不多 研究与大鼠衰老相关的气味记忆障碍尚未与 对来自不同感觉方式的刺激的记忆。因此，气味记忆是否存在尚不清楚。 与通过其他感觉方式编码的刺激的记忆相比，或多或少受到衰老的影响。因此，它是 尚不清楚衰老大鼠是否是了解年龄相关大脑变化如何产生的良好模型 老年人的气味记忆受损。这笔赠款的主要目的是调查 使用动物模型对嗅觉刺激的记忆进行正常老化。具体目标 1 将调查年龄- 嗅觉和视觉刺激的辨别和逆转学习的相关差异。具体目标 2 将 研究嗅觉和视觉刺激的工作记忆与年龄相关的差异。具体目标 3 将 研究嗅觉和视觉刺激的联想学习与年龄相关的差异。拟议的 实验将确定老年大鼠的气味记忆是否比视觉记忆受到更大的影响。这 实验结果将为了解衰老是否对人体产生类似的有害影响提供有价值的见解。 老鼠和人类的气味记忆。此外，研究结果将表明老年老鼠是否是一个好的老鼠 用于研究衰老对老年人气味记忆影响的动物模型。此外，结果将 说明通过不同感觉方式编码的刺激的记忆可能如何受到以下因素的不同影响 衰老以及年龄的增长如何对不同类型的记忆产生不同的影响。研究结果可能有 对未来衰老研究记忆范式的选择具有重要意义。用途 利用动物模型来研究衰老对气味记忆的影响将使研究人员能够 研究与年龄相关的神经解剖学和神经化学变化如何导致气味受损 记忆。