Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases

脑维生素E、饮食的流行病学研究

• 批准号: 7368669
• 负责人: Martha Clare Morris
• 金额: $ 68.74万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368669
• 关键词: Address; Alzheimer' s Disease; Amyloid deposition; Animal Model; Autopsy; Biochemical; Blood; Brain; Brain Diseases; Brain region; Cerebrospinal Fluid; Cerebrum; Chromosome Pairing; Clinical; Clinical Trials; Cognitive; Condition; Conflict (Psychology); Data; Data Collection; Dementia; Diet; Dietary intake; Disease; Dose; Eating; Elderly; Epidemiologic Studies; Epidemiology, Other; Food; Funding; Human; Impaired cognition; Infarction; Inflammation; Inflammatory; Insulin; Intake; Knowledge; Laboratory Animals; Lewy Bodies; Medical History; Motor; Nature; Nervous System Physiology; Neurofibrillary Tangles; Neuroglia; Neurologic; Neurologic Examination; Neurons; Outcome; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Participant; Pathologic; Pathology; Persons; Pilot Projects; Plasma; Population; Principal Investigator; Process; Public Health; Relative (related person); Religion and Spirituality; Request for Applications; Risk; Risk Factors; Semantic memory; Severities; Synapses; Testing; Therapeutic Agents; Tocopherols; Vitamin E; Vitamins; Work; age group; age related; alpha Tocopherol; blood glucose regulation; brain tissue; cohort; cost; disorder risk; mild neurocognitive impairment; multidisciplinary; nervous system disorder; neuropathology; oxidation; programs; prospective; relating to nervous system

This is the second revision of an application (1 R01 NS056397), "Epidemiologic Study of Brain Vitamin E, Diet and Age-Related Neurologic Diseases", which was not funded. This application proposes to use data from an existing longitudinal clinical-pathologic study, the Religious Orders study, to analyze biochemical levels of the various forms of vitamin E in post-mortem brain tissue and cerebrospinal fluid in 450 deceased participants as well as selected markers of neuropathology and neural reserve, oxidation, inflammation, and insulin activity, and to collect prospectively annual dietary exposure data on the entire cohort of 800 participants. The Religious Orders Study will provide at no cost to the proposed study, data on all non-dietary risk factors, all clinical outcome data on neurological diseases and cognitive and motor function, and most data on post-mortem neuropathology of brain tissue. Recent studies by this group and others suggest that high-dose a-tocopherol, which is currently being tested in clinical trials, may not be the effective therapeutic agent. If funded, the proposed study will have the unprecedented ability to relate brain levels of the various forms of vitamin E to clinical- pathologic outcomes relevant to Alzheimer's disease (AD) and parkinsonian signs as well as to dietary exposures. The proposed multidisciplinary team conducted a pilot study that suggests brain levels of both gamma and alpha tocopherols are inversely related with AD neuropathology and severity of parkinsonian signs, and positively associated with semantic memory. Substantiation of these associations in the entire cohort would be of the utmost importance to the public health, especially given the debilitating and incurable nature of these diseases, and their high occurrence among the fastest growing age group in the US population. Principal Investigator/Program Director (Last, First, Middle): Morris, Martha Clare This is the second revised R01 application to investigate the relations of tocopherols in the brain to age-related neurological diseases and to dietary tocopherols in an existing longitudinal clinical -pathologic study, the Religious Orders Study.

这是应用程序的第二次修订（1 R01 NS056397），“脑维生素E，饮食和与年龄相关的神经系统疾病的流行病学研究”，“ 没有资助。该申请建议使用现有的纵向临床病理学研究中的数据，《宗教命令研究》， 分析450名死者参与者中验尸脑组织和脑脊液中各种形式的维生素E的生化水平 以及精选的神经病理学和神经储备，氧化，炎症和胰岛素活性，并前瞻性地收集 全年800名参与者的饮食暴露数据。宗教命令研究将无需提供拟议的研究， 有关所有非官方危险因素的数据，关于神经疾病以及认知和运动功能的所有临床结果数据，以及大多数数据 脑组织的验尸神经病理学。该小组和其他人的最新研究表明，高剂量的A-生育酚目前是 在临床试验中测试，可能不是有效的治疗剂。如果资助，拟议的研究将具有前所未有的能力 将各种形式的维生素E的大脑水平与与阿尔茨海默氏病（AD）和帕金森氏病有关的临床病理结局 体征以及饮食暴露。拟议的多学科团队进行了一项试点研究，该研究表明伽玛和 α生育酚与帕金森氏症的AD神经病理学和严重程度成反比，并且与语义记忆呈正相关。 在整个队列中对这些协会的证实对公共卫生至关重要，尤其是考虑到 这些疾病的衰弱和无法治愈的性质，以及它们在美国人口增长最快的年龄段中的高度发生。 首席调查员/计划主任（最后，第一，中间）：莫里斯，玛莎·克莱尔（Martha Clare）这是第二次修订的R01调查申请 在现有的纵向临床中 - 病理学研究，宗教秩序研究。