MIND Diet Intervention to Prevent Alzheimer's Disease

MIND 饮食干预预防阿尔茨海默病

• 批准号: 9081135
• 负责人: Martha Clare Morris
• 金额: $ 277.31万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9081135
• 关键词: Adult; Adverse effects; Affect; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease risk; American; Amyloid beta-Protein; Animals; Atrophic; Berry; Biochemical; Biochemical Markers; Biological; Biological Markers; Blood specimen; Body Weight decreased; Boston; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Cardiovascular system; Carotenoids; Chicago; Cholesterol; Clinic; Clinical Trials; Cognition; Cognitive; Counseling; DASH diet; DNA; Data; Dementia; Diabetes Mellitus; Diet; Dietary Component; Dietary Intervention; Dietary Practices; Disease; Dose; Epidemiology; Etiology; Family history of; Fishes; Folic Acid; Food; Foundations; Future; Grapes; Guidelines; Head; Hippocampus (Brain); Hospitals; Hybrids; Hypertension; Impaired cognition; Incidence; Individual; Inflammation; Intake; Internet; Intervention; Intervention Trial; Juice; Laboratories; Laboratory Study; Link; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Medicine; Mediterranean Diet; Modification; National Institute on Aging; Nerve Degeneration; Nutrient; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Overweight; Oxidative Stress; Participant; Patients; Phase; Physical activity; Plants; Plasma; Population; Prevalence; Prevention; Prevention strategy; Prevention trial; Public Health; Race; Randomized Controlled Trials; Reporting; Research Personnel; Rest; Risk Factors; Role; Source; Specific qualifier value; Staging; Testing; Tissues; Trust; Universities; Unsaturated Fats; Vegetables; Vitamins; Woman; age group; aged; base; brain health; brain volume; cardiovascular risk factor; chronic depression; clinical practice; clinical research site; cognitive function; cognitive testing; cohort; cost; design; dietary approach; disorder prevention; drinking; gamma-Tocopherol; good diet; lifestyle intervention; metabolomics; multidisciplinary; neglect; neuroimaging; nutrition; pre-clinical; prevent; primary outcome; psychological distress; randomized trial; response; saturated fat; sex; trial design; web site

This R01 application, “MIND Diet Intervention to Prevent Alzheimer Disease,” is a Phase III randomized controlled trial designed to test the effects of a 3-year intervention of a hybrid of the Mediterranean and DASH diets, called MIND, on cognitive decline among 600 individuals 65+ years without cognitive impairment who are overweight and have suboptimal diets. The proposed MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is a hybrid of the Mediterranean and DASH diets but with selected modifications based on the most compelling evidence in the diet-dementia field. The MIND diet has the same basic components of the DASH and Mediterranean diets, such as emphasis on natural plant-based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food component servings that reflect the nutrition-dementia evidence. There is a substantial body of evidence from epidemiological, animal and laboratory studies to link diet to brain health. Thus, the field is primed for the conduct of a large-scale prevention trial to establish a causal relation between diet and AD prevention. Establishing such a relation would greatly impact the public health and provide credibility to or refute numerous claims that various foods and dietary patterns are protective against AD. Dietary guidelines could be developed from the trial for use in clinical practice to inform patients about disease prevention. The proposed hybrid diet intervention has demonstrated effects on the prevention and treatment of most of the primary AD risk factors such as hypertension and diabetes, and the suppression of the two major underlying mechanisms of AD, oxidative stress and inflammation. The trial will employ a parallel group design comparing the effects on cognitive outcomes of the MIND intervention diet plus mild caloric restriction for weight loss to the control diet, usual diet with mild caloric restriction for weight loss. Biological effects of the MIND diet will be assessed by measurement of brain macro- and micro-structural integrity in 300 randomly selected participants. Other biochemical markers will be assessed in the entire cohort of 600 participants, including: plasma Abeta 42/Abeta 40, brain-derived neurotrophic factor (BDNF) and plasma markers of oxidative stress and inflammation. In addition, the trial will examine potential effect mediators and modifiers by a number of cardiovascular risk factors, AD biomarkers, and biological mechanisms. The proposed study has two clinical sites, one in Chicago (Rush University) and one in Boston (Harvard University), and centralized laboratories for data coordinating and analyses (Brigham & Women’s Hospital), neuroimaging analyses (Rush University), and specialized laboratories for tissue biochemical analyses.

R01应用“预防阿尔茨海默氏病的心理饮食干预”是III期随机分组的 对照试验旨在测试地中海和破折号的三年干预的影响 饮食，被称为思维，关于600个人的认知能力下降，没有认知障碍，谁 超重，饮食良好。拟议的思维饮食（地中海 - 划线干预 神经退行性延迟）是地中海和破折号的杂种，但进行了选定的修改 基于饮食降解领域中最引人注目的证据。思维饮食具有相同的基本 仪表板和地中海饮食的成分，例如强调天然植物性食品和有限 动物和高饱和脂肪食品，但独特地指定了绿叶蔬菜和浆果以及食物 反映营养止血证据的成分份量。有大量证据来自 流行病学，动物和实验室研究将饮食与大脑健康联系起来。那，该领域是为 进行大规模预防试验，以建立饮食与预防饮食之间的因果关系。 建立这种关系将极大地影响公共卫生，并为许多人提供信誉 声称各种食物和饮食模式受到保护。饮食指南可能是 从试验中开发用于临床实践，以告知患者疾病预防。提议 混合饮食干预已经显示出对大多数主要AD的预防和处理的影响 高血压和糖尿病等危险因素，以及两种主要基础机制的抑制 AD，氧化应激和炎症。该试验将采用平行组设计，比较对 思维干预饮食的认知结果以及轻度热量限制对控制饮食的体重减轻， 通常的饮食饮食轻度热量限制以减轻体重。思维饮食的生物学作用将由 在300位随机选择的参与者中测量脑宏观和微观结构完整性。其他 生化标记将在整个600名参与者的队列中进行评估，包括：ABETA 42/abeta 40，脑衍生的神经营养因子（BDNF）和氧化应激的等离子体标记物和 此外，该试验将检查潜在的效应介体和修饰符 心血管危险因素，AD生物标志物和生物学机制。拟议的研究有两个临床 网站，一个在芝加哥（拉什大学），一个位于波士顿（哈佛大学）的地点，而集中实验室 数据协调和分析（杨百翰医院），神经影像分析（拉什大学）和 用于组织生化分析的专门实验室。