Xenogen IVIS 200 Imager

Xenogen IVIS 200 成像仪

基本信息

批准号：
6877292
负责人：
G. Gary Sahagian
金额：
$ 26.25万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-02-15 至 2006-02-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6877292
关键词：
bioluminescence biomedical equipment purchase imaging /visualization /scanning

项目摘要

DESCRIPTION (provided by applicant): Biophotonic imaging of small animals using bioluminescent and fluorescent probes has become a state-of-the-art technology for studying normal and disease processes in vivo and is providing powerful new approaches for studying tumor biology, infectious disease, and gene expression. This application requests funds for a Xenogen MS 200 biophotonic imaging system to support a wide range of research being carried out at Tufts University Schools of Medicine and Dental Medicine and the Tufts-New England Medical Center in Boston. A core group of 12 well-funded NIH investigators will be the primary users of the instrument and will account for approximately 79% of its use. A small animal imaging facility will be established to house the imager. Establishment of the facility is strongly supported by the Chairman of the Department of Physiology, who has offered laboratory space for the facility and support for administration of the grant, by the Dean of the Medical School, who will provide funds for renovation of the laboratory space, and by the Vice President of Research at Tufts-New England Medical Center who has offered funds for maintenance of the instrument. The facility will be directed by the PI and the instrument will be operated and managed on a day-to-day basis by a full time research associate who will also train new users. An advisory committee consisting of the PI, and representatives from Tufts-New England Medical Center, the Division of Laboratory Animal Medicine and the Department of Physiology will oversee use of the MS 200 system and develop policies for use and equitable sharing of the instrument. At present, the PI has an MS imager on loan from Xenogen that is being shared by several of the major users. However, this instrument will have to be returned to Xenogen and no other suitable imager is available for use at Tufts University or the Tufts-New England Medical Center. The presence of the new MS 200 imaging system and imaging facility will greatly enhance the research carried out on the Tufts University Health Sciences Campus in Boston.

描述（由申请人提供）：使用生物发光和荧光探针对小动物进行生物光子成像已成为研究体内正常和疾病过程的最先进技术，并为研究肿瘤生物学、传染病和基因表达提供了强大的新方法。该申请要求为 Xenogen MS 200 生物光子成像系统提供资金，以支持塔夫茨大学医学院和牙科医学院以及波士顿塔夫茨新英格兰医学中心正在进行的广泛研究。由 12 名资金充足的 NIH 研究人员组成的核心小组将成为该仪器的主要用户，约占其使用量的 79%。将建立一个小型动物成像设施来容纳成像仪。该设施的建立得到了生理学系主任的大力支持，他为该设施提供了实验室空间，并得到了医学院院长的资助管理支持，他将为实验室空间的翻修提供资金，以及塔夫茨-新英格兰医学中心的研究副总裁，他为仪器的维护提供了资金。该设施将由 PI 指导，仪器将由一名全职研究员进行日常操作和管理，该研究员还将培训新用户。由 PI 以及塔夫茨新英格兰医学中心、实验动物医学部和生理学系的代表组成的咨询委员会将监督 MS 200 系统的使用，并制定该仪器的使用和公平共享政策。目前，PI 从 Xenogen 借用了一台 MS 成像仪，并由几个主要用户共享。然而，该仪器必须返回 Xenogen，并且塔夫茨大学或塔夫茨新英格兰医学中心没有其他合适的成像仪可供使用。新型 MS 200 成像系统和成像设施的出现将极大地增强在波士顿塔夫茨大学健康科学校区开展的研究。