IVIS 200 Imaging System

IVIS 200 成像系统

• 批准号: 6877460
• 负责人: Brunhilde H. Felding
• 金额: $ 27.1万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877460
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; imaging /visualization /scanning

DESCRIPTION (provided by applicant): The major goal of this application is to provide our local scientific community with access to a shared non-invasive optical imaging instrument to increase the innovation, efficiency, and synergy of our biomedical research projects. We identified sixteen NIH funded investigators of The Scripps Research Institute, the Burnham Institute, and the La Jolla Institute for Molecular Medicine who have an urgent need for an imaging modality that will allow in vivo monitoring of 1) tumor development and metastatic progression, 2) specific tracking of tumor cells, stem or progenitor cells, and other cell types involved in development, tissue remodeling, injury repair and regeneration, 3) gene expression, 4) proteolytic activity, and 5) treatment efficacy in disease and pathological conditions. For use as a shared instrument, we propose a cost effective and easy-to-use, yet state-of-the-art modality for non-invasive real time imaging of small animals, based on the detection of fluorescence and bioluminescence signals. The Scripps Research Institute will provide all ancillary facilities and staff to operate and manage instrument use and user training on a cost recovery basis. It will also provide access to a bioinformatics infrastructure to facilitate data analysis, management, archiving, and links to public databases. The organization and use of the shared instrument will foster research collaborations within the user group and open new avenues for biomedical research, enhancing the information gained from each of the participating projects toward understanding the complexity of molecular and cell biological events in live animal models.

描述（由申请人提供）： 该应用程序的主要目标是为我们当地的科学界提供共享的非侵入性光学成像仪器，以提高我们生物医学研究项目的创新、效率和协同作用。我们确定了来自斯克里普斯研究所、伯纳姆研究所和拉霍亚分子医学研究所的 16 名 NIH 资助的研究人员，他们迫切需要一种成像方式，能够对 1) 肿瘤发展和转移进展进行体内监测，2)特异性追踪肿瘤细胞、干细胞或祖细胞以及参与发育、组织重塑、损伤修复和再生的其他细胞类型，3) 基因表达，4) 蛋白水解活性，以及​​ 5)对疾病和病理状况的治疗功效。 为了用作共享仪器，我们提出了一种基于荧光和生物发光信号检测的经济有效、易于使用且最先进的小动物非侵入式实时成像方式。 斯克里普斯研究所将提供所有辅助设施和人员，以在成本回收的基础上操作和管理仪器使用和用户培训。它还将提供对生物信息学基础设施的访问，以促进数据分析、管理、归档和公共数据库的链接。共享仪器的组织和使用将促进用户组内的研究合作，并为生物医学研究开辟新途径，增强从每个参与项目中获得的信息，以了解活体动物模型中分子和细胞生物学事件的复杂性。