TRANSGENIC MOUSE CORE

转基因小鼠核心

• 批准号: 7170467
• 负责人: MICHAEL J KERN
• 金额: $ 26.52万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170467
• 关键词: cardiovascular disorder; clinical research; genetics; health science research; pathologic process

DESCRIPTION (provided by applicant): We will establish a center to promote the study of cardiovascular diseases in South Carolina. Our COBRE focus on cardiovascular disease is significant because the citizens of our state are more prone to cardiovascular disease than anywhere else in the nation. For this reason, the two medical schools in the state have united to develop the South Carolina COBRE on Cardiovascular Disease. This COME will significantly augment joint efforts in South Carolina to recruit, train and retain a critical mass of investigators with multidisciplinary skills and adequate infrastructure to: (1) collaborate effectively in fundamental mechanistic studies of cardiovascular diseases, and (2) compete successfully at the national level for NIH and other merit-reviewed funding required to support and extend their research endeavors. Five scientific projects proposed by talented, newly recruited tenure-track faculty from five different departments, three high tech scientific cores (transgenics, imaging, microarray/proteomics) directed by outstanding investigators with proven track records in their area of expertise and an administrative/mentoring core comprise the proposed center. The overarching theme is that cardiovascular diseases derive from final common pathogenic pathways: proliferation, remodeling, apoptosis, transdifferentiation and vasculogenesis, each of which is the focus of one or more projects. While the thematic focus is cardiovascular, the operant theme for implementation is mentoring. In states that are less competitive for research funding at the national level, effective mentoring of new investigators is an essential element of a research development plan. This proposal addresses this need directly by: (1) pairing targeted investigators with established NIH-funded researchers who have exceptional mentoring track records as well as relevant critical expertise; (2) developing structured activities for skills acquisition and enhancement, such as seminars, journal clubs, retreats and special courses; (3) guaranteeing access to essential core resources with sufficient scientific expertise and technical support to optimize their use; and (4) implementing a regular schedule (checkpoints) of progress reports and evaluation with critical assistance from an External Advisory Committee of nationally recognized scientists.

描述（由申请人提供）：我们将建立一个中心来促进 南卡罗来纳州心血管疾病研究。我们的 COBRE 专注于 心血管疾病很重要，因为我们州的公民 比全国其他地方更容易患心血管疾病。为了 为此，该州的两所医学院联合开发了 南卡罗来纳州 COBRE 关于心血管疾病的研究。这次 COME 将显着 加强南卡罗来纳州招募、培训和留住人才的联合努力 具有多学科技能和足够能力的关键研究人员 基础设施：(1) 在基本机制方面进行有效协作 心血管疾病的研究，以及（2）在 国家卫生研究院 (NIH) 的国家级资金和其他需要支持的经过评审的资金 并扩大他们的研究工作。提出的五个科学项目 来自五个不同国家的才华横溢的新聘终身教授 部门，三个高科技科学核心（转基因、成像、 微阵列/蛋白质组学）由具有可靠跟踪记录的杰出研究人员指导 其专业领域的记录和行政/指导核心 包括拟议的中心。首要主题是心血管 疾病源自最终的共同致病途径：增殖， 重塑、细胞凋亡、转分化和血管生成，其中每一个 是一个或多个项目的焦点。虽然主题重点是 心血管，实施的操作主题是指导。在各州 在国家层面的研究经费方面竞争力较弱， 对新研究者的有效指导是研究的一个基本要素 发展计划。该提案通过以下方式直接解决了这一需求：（1）配对 目标研究人员与 NIH 资助的研究人员 卓越的指导记录以及相关的关键专业知识； (2) 开展结构化活动以获取和提高技能， 例如研讨会、期刊俱乐部、静修会和特别课程； (3) 以充分的科学保障获取必要的核心资源 优化其使用的专业知识和技术支持； (4) 实施 进度报告和评估的定期时间表（检查点） 来自国家外部咨询委员会的重要协助 公认的科学家。