COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

COBRE：UVM：核心 D：转化神经科学培训

• 批准号: 7170478
• 负责人: FELIX P ECKENSTEIN
• 金额: $ 16.7万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170478
• 关键词: biological signal transduction; neurogenetics; neuroregulation; neurosciences

DESCRIPTION (provided by applicant): The goal of this application is to establish a Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM). The specific aims of this proposal are: Specific Aim 1: Establish the research and intellectual infrastructure to support a University-wide Center for Neuroscience Excellence at UVM. Goals of this aim include: 1) to establish a mentoring program to support junior neuroscience faculty; 2) to establish an imaging/physiology core to support the research projects of the junior faculty; 3) to establish a cellular/molecular core to support the research projects of the junior faculty; 4) to establish a University-wide Neuroscience Seminar Series and Annual Neuroscience Retreat; 5) to establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research and 6) to establish a University-wide mechanism for Neuroscience Graduate Education. Specific Aim 2: Support the research development of a core group of junior faculty who will be future leaders in the Center for Neuroscience Excellence. Faculty to be supported and their project titles are: 1) Dr. Rona Delay, Department of Biology: Chloride homeostasis in olfactory neurons; 2) Dr. William Falls, Department of Psychology:Molecular and genetic analysis of learned fear reduction in mice; 3) Dr. Anthony Morielli, Department of Pharmacology: Kinase and cytoskeletal regulation of potassium channels; 4) Dr. Matthew Rand, Department of Anatomy and Neurobiology: Proteolytic modulation of Notch signaling in neurogenesis and 5) Dr. George Wellman, Department of Pharmacology: Mechanisms of cerebral vasospasm in subarachnoid hemorrhage. UVM has established investigators in three areas of neuroscience: molecular/developmental, cellular/systems and clinical/behavioral neuroscience. Award of this application would provide a mechanism to significantly expand research strength in these existing areas of neuroscience emphasis, to integrate basic with clinical neuroscience, and to promote research collaborations university-wide. A level of excellence in research and training will be fostered that is not possible without external support. Productivity of both junior and senior investigators will be stimulated, and a long term mentoring framework will be created. UVM is a small institution in a rural state with limited resources; an award would substantially expand our research infrastructure and significantly increase faculty competitiveness.

描述（由申请人提供）：本申请的目标是 建立神经科学生物医学卓越研究中心（COBRE） 在佛蒙特大学（UVM）。该提案的具体目标是： 具体目标 1：建立研究和知识基础设施 支持UVM全校神经科学卓越中心。目标 这一目标包括： 1) 建立一个指导计划来支持青少年 神经科学系； 2）建立影像/生理学核心来支持 初级教师的研究项目； 3）建立一个 支持初级研究项目的细胞/分子核心 学院; 4）建立全校范围的神经科学研讨会系列和 年度神经科学静修会； 5）建立沟通机制 基础科学家和临床医生之间，促进发展 转化研究和 6) 建立大学范围内的机制 神经科学研究生教育。 具体目标 2：支持初级核心团队的研究发展 教师将成为神经科学卓越中心未来的领导者。 需要支持的教师及其项目名称是：1) Rona Delay 博士， 生物学系：嗅觉神经元中的氯离子稳态； 2）博士。 威廉·福尔斯，心理学系：分子和遗传分析 老鼠学会了减少恐惧； 3) 安东尼·莫里埃利博士，系 药理学：钾通道的激酶和细胞骨架调节； 4）博士。 马修·兰德（Matthew Rand），解剖学和神经生物学系：蛋白水解调节 神经发生中的 Notch 信号传导和 5) George Wellman 博士，系 药理学：蛛网膜下腔出血脑血管痉挛的机制。 UVM 在神经科学的三个领域建立了研究人员： 分子/发育、细胞/系统和临床/行为 神经科学。该申请的授予将提供一种机制 显着扩大神经科学现有领域的研究实力 强调基础与临床神经科学的结合，促进 全校范围内的研究合作。卓越的研究水平 如果没有外部支持，培训是不可能实现的。 初级和高级研究人员的生产力都将得到激发，并且 将创建长期指导框架。 UVM 是一个小型机构 资源有限的农村国家；一个奖项将大大扩展我们的 研究基础设施并显着提高教师竞争力。