Resorbable Calcium Phosphate Ceramics for Bone Graft.

用于骨移植的可吸收磷酸钙陶瓷。

• 批准号: 7694825
• 负责人: SUSMITA BOSE
• 金额: $ 3.38万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7694825
• 关键词: Autologous Transplantation; Behavior; Biodegradation; Biological; Bone Growth; Bone Regeneration; Bone Substitutes; Bone Tissue; Bone Transplantation; Bone remodeling; Cells; Ceramics; Cereals; Characteristics; Chemicals; Chemistry; Clinical; Data; Defect; Development; Elements; Face; Goals; Harvest; Healed; Human; Implant; In Vitro; Kinetics; Knowledge; Lead; Length; Magnesium; Malignant Bone Neoplasm; Mechanics; Modeling; Operative Surgical Procedures; Oryctolagus cuniculus; Osteoblasts; Osteoclasts; Osteoporosis; Oxides; Physiologic calcification; Porosity; Process; Property; Public Health Applications Research; Range; Rate; Rattus; Research; Research Project Grants; Sampling; Series; Silicon; Site; Spinal; Spinal Fusion; Strontium; Structure; Testing; Time; Tissue Engineering; Trace Elements; Transplanted tissue; Zinc; base; biomaterial compatibility; bone; bone cell; bone healing; calcium phosphate; cell growth; craniomaxillofacial; design; desire; healing; in vivo; nanoparticle; nanopowder; nanoscale; novel; physical property; reconstruction; repaired; scaffold; size; success

DESCRIPTION (provided by applicant): Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. There is a need for the development of biodegradable ceramic materials with controlled degradation kinetics that will act as a scaffold and support bone remodeling. Our long range goal is to elucidate strength loss mechanism in CaP based material and scaffold to develop bone graft for specific application. Fundamental information on controlled degradation behavior of CaP based materials to identify optimal material composition can help us design and tailor resorbable tissue engineered bone replacement based on application needs. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in CaP based ceramics can modify strength loss in these materials. Our preliminary data indicate that a minimum amount of trace elements (dopants) can have significant effects on physical and mechanical properties of CaPs. Cell-materials interactions can also be influenced by the presence of trace elements. The specific aims are 1) To investigate effects of nanoscale CaP with three different Ca to P ratios, 1.25:1, 1.33:1 and 1.5:1, through synthesis, processing, characterization and in vitro and in vivo bone cell-materials interactions. 2) To determine the effects of four dopants, Zinc, Magnesium, Silicon, and Strontium oxides in single and multi-element composition, along with three CaP ceramics with Ca:P = 1.25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity and verify the influence of porosity on their properties and study in vitro and in vivo interactions. In order to accomplish these aims, we will conduct a series of studies including synthesis of nanoscale CaPs with single and multi element dopants, characterize their chemical, physical and mechanical properties, and in vitro and in vivo strength loss behavior in rat and rabbit models. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications. PUBLIC HEALTH RELEVANCE Resorbable Calcium Phosphate Ceramics for Bone Graft Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in Calcium phosphate (CaP) based ceramics can modify strength loss in these materials. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications.

描述（由申请人提供）：基于磷酸钙（CAP）的陶瓷由于其出色的生物相容性而用于硬组织工程中。需要开发具有控制降解动力学的可生物降解陶瓷材料，这些材料将充当脚手架并支持骨骼重塑。我们的远距离目标是阐明基于CAP的材料和支架中的强度损失机制，以开发用于特定应用的骨移植物。基于CAP的材料的受控降解行为以识别最佳材料组成的基本信息可以帮助我们根据应用需求设计和量身定制可吸收组织工程的骨骼。这项研究的目的是测试我们的中心假设，即基于CAP的陶瓷中的化学和微观结构可以改变这些材料的强度损失。我们的初步数据表明，最小量的微量元素（掺杂剂）可能对CAP的物理和机械性能产生重大影响。细胞材料相互作用也可能受到痕量元件的存在。具体目的是1）通过合成，加工，表征，体外和体内骨细胞材料相互作用，研究具有三种不同Ca与P比的纳米级帽的纳米级帽的影响。 2）确定单个和多元素组成中四个掺杂剂，锌，镁，硅和氧化物的影响，以及三个具有CA的帽陶瓷：P = 1.25：1，1.33：1，1.33：1和1.5：1在体外和体内吸收上。 3）使用快速原型开发3D互连量身定制的孔隙率结构，平均300微米的孔径和30和60的体积％孔隙率，并验证孔隙率对其性质和体外和体内相互作用的影响。为了实现这些目标，我们将进行一系列研究，包括与单一和多元素掺杂剂的纳米级帽合成，表征其化学，物理和机械性能，以及大鼠和兔模型中的体外和体外强度损失行为。可以想象，拟议的研究的结果将导致帽子的发展，并具有量身定制的降解动力学，可用于脊柱融合，上颌和颅骨植入物以及小规模的骨缺损应用。 公共卫生相关性可吸收磷酸钙陶瓷骨移植 基于磷酸钙（CAP）的陶瓷由于其出色的生物相容性而用于硬组织工程中。这项研究的目的是测试我们的中心假设，即基于磷酸钙（CAP）陶瓷的化学和微观结构可以改变这些材料中的强度损失。可以想象，拟议的研究的结果将导致帽子的发展，并具有量身定制的降解动力学，可用于脊柱融合，上颌和颅骨植入物以及小规模的骨缺损应用。