Chemical Vapour Deposition for the Generation of Visible Light Activated Antimicrobial Coatings

用于生成可见光激活抗菌涂层的化学气相沉积

基本信息

批准号：
EP/E026141/1
负责人：
Ivan Parkin
金额：
$ 56.51万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FE026141%2F1
关键词：
Chemical Vapour Deposition Generation Visible

项目摘要

The goal of this research is to prepare new antimicrobial coatings that will work under normal room lighting conditions. The new coatings will be able to use visible light to dsetroy and decontaminate the surface and will be able to do so for all bacteria and viruses. They will be particularly useful in a hospital environment where they will be of great benefit in reducing transmission of hospital acquired infections- in particular MRSA.The coatings work by absorbing visible light and converting this into active species called radicals that chew up and destroy the walls of a bacteria or virus and hence inactivate the organism. The key part of the new science here is that by modifying an existing material called titanium dioxide we will be able to ensure that it can capture visible light. Up to now the titanium dioxide coatings would only be effective in combination with ultra-violet light from lamp sources. These are dangerous (direct UV can cause eye damage), energy intensive and not pratical to use on a large scale.The new coatings will be produced by chemical vapour deposition. This is a method of laying down a coating from material in the gas phase. We have developed a new combinatorial approach which enables films of graded composition to be depositied. By measuring the properties of the film at each point we are very rapidly able to examine what is the best composition mix in the film to obtain maximum visible light havesting.The efficacy of the new coatings at destroying organic chemicals, bacteri and a virus will be examined using normal room lighting.One further feature of the new coatings is that form very slippery surfaces. In fact water forms puddles and sheets on the surface rather than droplets or rivulets. This means that the coatings wash down uniformly any dirt or bacteria on their surfaces. One exciting aspect of the project is to measure how well bacteria will adhere to the surface and to measure the ease of biofilm formation. The biofilm stage is a critical one in assessing how well a film will form, adhere and colonise - contaminate a surface. We anticipate that these new coatinsg will prove exceptionally difficult for bacteria to colonise.

这项研究的目的是准备新的抗菌涂层，这些抗菌涂层将在正常的房间照明条件下起作用。新的涂层将能够使用可见光来消除表面并净化表面，并能够为所有细菌和病毒做到这一点。它们将在医院环境中特别有用，在医院环境中，它们将在减少医院获得感染的传播方面具有很大的好处 - 尤其是MRSA。涂料通过吸收可见光并将其转化为称为激进物种的活性物种来咀嚼细菌或病毒的壁，从而使生物体失活。这里新科学的关键部分是，通过修改称为二氧化钛的现有材料，我们将能够确保它可以捕获可见光。到目前为止，二氧化钛涂层只能与灯源的超紫色光结合使用。这些是危险的（直接的紫外线会造成眼睛损伤），能量密集型，而不是大规模使用。新涂层将由化学蒸气沉积产生。这是一种在气相中从材料中铺设涂层的方法。我们已经开发了一种新的组合方法，该方法可以存入分级成分的膜。通过测量膜在每个点的性质，我们非常快速地检查膜中最佳的成分混合物以获得最大的可见光，以获得最大的可见光。实际上，水在表面而不是液滴或铆钉上形成水坑和床单。这意味着涂料在其表面上均匀地洗净任何污垢或细菌。该项目的一个令人兴奋的方面是测量细菌粘附在表面的状况以及生物膜形成的易感性。生物膜阶段是评估薄膜形成，粘附和定殖如何污染表面的关键阶段。我们预计这些新的Coatinsg将证明细菌殖民地殖民地非常困难。